Results 261 to 270 of about 388,340 (363)

Mapping of the functional determinants of the integrin beta 1 cytoplasmic domain by site-directed mutagenesis. [PDF]

, 1990
Eugene E. Marcantonio, Jun‐Lin Guan, Jane E. Trevithick, Richard O. Hynes   +3 more
openalex   +1 more source

Engineered Hydrogels for Organoid Models of Human Nonalcoholic Fatty Liver Disease

Advanced Science, EarlyView.
Nonalcoholic fatty liver disease (NAFLD) is characterized by lipid accumulation and extracellular matrix stiffening. An in vitro NAFLD model is developed using engineered hydrogels (G′ ≈ 1–6 kPa) and iPSC‐derived hepatic organoids. It is demonstrated that higher stiffness can increase lipid droplet accumulation, fibrosis, and metabolic dysregulation ...
Yueming Liu, Aidan E. Gilchrist, Patrik K. Johansson, Yuan Guan, Jaydon D. Deras, Yu‐Chung Liu, Sofia Ceva, Michelle S. Huang, Renato S. Navarro, Annika Enejder, Gary Peltz, Sarah C. Heilshorn   +11 more
wiley   +1 more source

MOSPD2 regulates the activation state of αLβ2 integrin to control monocyte migration: applicability for treatment of chronic inflammatory diseases. [PDF]

Immunol Res
Salem Y, Yacov N, Kafri P, Propheta-Meiran O, Karni A, Maharshak N, Furer V, Elkayam O, Mendel I.   +8 more
europepmc   +1 more source

Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes

, 1991
David J. Erle, C. Rüegg, Dean Sheppard, Robert Pytela   +3 more
openalex   +1 more source

Cellular invasion into matrix beads: Localization of fa integrins and fibronectin to the invadopodia [PDF]

, 1991
Susette C. Mueller, Wen‐Tien Chen
openalex   +1 more source

Mechanisms and Therapeutic Strategies for Minority Cell‐Induced Paclitaxel Resistance and Tumor Progression Mediated by Mechanical Forces

Advanced Science, EarlyView.
This study provides new perspectives into the interactions between mechanical forces and cellular dynamics within the tumor microenvironment, particularly elucidating how minority Paclitaxel‐resistant cancer cells (MRCs) promote tumor progression and treatment resistance through mechanical forces and also providing effective treatment strategies for ...
Xueyan Feng, Di Zhang, Guoxun Wang, Liwei Lu, Feng Feng, Xiuyu Wang, Chanchan Yu, Yahong Chai, Jin Zhang, Wenchao Li, Jing Liu, Hongxia Sun, Li Yao   +12 more
wiley   +1 more source

An optimized integrin α6-targeted peptide capable of delivering toxins for melanoma treatment. [PDF]

J Transl Med
Zhao Z, Li ZQ, Huang YB, Liu MM, Cao F, Bu GL, Xu PF, Fang Q, Hu ZL, Wu D, Feng GK, Liu XK.   +11 more
europepmc   +1 more source

A point mutation in the integrin beta 3 cytoplasmic domain (S752-->P) impairs bidirectional signaling through alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) [PDF]

, 1994
YP Chen, TE O'Toole, Jari Ylänne, JP Rosa, MH Ginsberg   +4 more
openalex   +1 more source

Single‐Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment

Advanced Science, EarlyView.
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song, Zhichao Tong, Guixiang Xie, Yaowei Li, Yubo Zhao, Fengpu Fan, Zongzheng Yang, Qing Shi, Qian Zhang, Feng Wen, Hongxue Meng, Haonan Li, Pengyu Guo, Dayong Hou, Zhenwei Zhang, Zhihao Yin, Ziyi Liu, Jianwei Wang, Peng Zhang, Peng Dai, Changfu Li, Lichen Teng, Yangyang Xu, Dexin Ding, Tao Xu, Jianzhang Li, Yongsheng Chen, Yu Qiu, XiaoWei Hu, Wentao Liu, Liang Wu, Roman Nawroth, Guibo Li, Hang Su, Ziqing Deng, Ziqi Wang, Di Wang, Wanhai Xu   +37 more
wiley   +1 more source

A Novel KGD-Based αIIbβ3 Antagonist Prevents Arterial Thrombosis While Preserving Hemostasis and Avoiding Thrombocytopenia. [PDF]

Int J Mol Sci
Kuo YJ, Chung CH, Chen CC, Liu JC, Chiou KR, Sheu JR, Chuang WJ, Huang TF.   +7 more
europepmc   +1 more source