Results 271 to 280 of about 388,340 (363)

Signal transduction by the platelet integrin alpha IIb beta 3: induction of calcium oscillations required for protein-tyrosine phosphorylation and ligand-induced spreading of stably transfected cells. [PDF]

, 1992
Anthony J. Pelletier, Sarah Bodary, Arthur D. Levinson   +2 more
openalex   +1 more source

A Self‐Assembling LYTAC Mediates CTGF Degradation and Remodels Inflammatory Tumor Microenvironment for Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
A CTGF‐LYTAC nanoplatform is developed to selectively degrade connective tissue growth factor (CTGF) in triple‐negative breast cancer (TNBC), inhibiting TGF‐β signaling and cell interactions in the tumor microenvironment (TME). This strategy effectively suppresses tumor growth and metastasis, outperforming antibody‐based therapy.
Jia‐Yi Lin, Ye Wu, Xiao‐Hui Liang, Min Tang, Xin Sun, Sheng‐Xin Lu, Jin‐Mei Jin, Xin Guo, Bei Wang, Hong‐Zhuan Chen, Wei‐Dong Zhang, Xin Luan   +11 more
wiley   +1 more source

The NADC30-like PRRSV activates the integrin αV subunit to facilitate its entry into Marc-145 cells. [PDF]

PLoS One
Li C, Cui J, Zheng H, Sha Z, Wei R, Wu R, Ni B.   +6 more
europepmc   +1 more source

CCN1 Enhances Tumor Immunosuppression through Collagen‐Mediated Chemokine Secretion in Pancreatic Cancer

Advanced Science, EarlyView.
CCN1 modulates the tumor microenvironment in pancreatic cancer by promoting collagen‐dependent chemokine production, thereby facilitating immune evasion. Deletion of CCN1 not only suppresses tumor growth but also enhances immune cell infiltration and increases tumor sensitivity to both chemotherapy and immunotherapy.
Hongjie Fan, Huzi Zhao, Lili Gao, Yucheng Dong, Pei Zhang, Pengfei Yu, Yunfei Ji, Zhe‐Sheng Chen, Xinmiao Liang, Yang Chen   +9 more
wiley   +1 more source

Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury in Diabetic Nephropathy Rats by Inhibiting Angpltl4/Integrin <i>β</i>3 in the Glomerulus. [PDF]

J Diabetes Res
Liu S, Meng M, Huang C, He L, Wang P, Tang Z, Ran X, Gao H, Guo Y, He Y, Chen J, Hu H, He S, Zhao Y, Hou Z, Li L, Li W, Wang W, Wang X.   +18 more
europepmc   +1 more source

QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
High QSOX2 enhances stemness, drug resistance, and metastasis of ESCC cells. QSOX2‐mediated disulfide bond modification activates mTOR/c‐Myc signaling. CAFs‐secreted IGF‐1 drives mTOR/c‐Myc/QSOX2 positive feedback loop. Combining Ebselen, rapamycin, and cisplatin induces tumor dormancy in mice.
Wo‐Ming Chen, Xiao‐Ping Zhang, Xiao Sun, Hai‐Cheng Liu, Yuan‐Yuan Yan, Xue Wei, Yu Liang, Yue Feng, Zhengjie Chen, Yongxu Jia, Chen Jiang, Qian Yan, Lei Li   +12 more
wiley   +1 more source

Integrine [PDF]

, 2017
openaire   +1 more source

⁶⁸Ga-Trivehexin: Current Status of αvβ6-Integrin Imaging and Perspectives. [PDF]

Cancers (Basel)
Urso L, Napolitano R, Speltri G, Tuncel M, Badrane I, Uccelli L, Porto F, Martini P, Niorettini A, Cittanti C, Bartolomei M, Boschi A.   +11 more
europepmc   +1 more source

Reinforcing Stromal Cell Spheroid Through Red‐Light Preconditioning for Advanced Vascularization

Advanced Science, EarlyView.
This study presents a novel approach to enhance stromal cell therapy for myocardial infarction by combining OLED‐based photobiomodulation (OPBM) preconditioning with 3D spheroid culture of hADSCs. The engineered spheroids improve angiogenesis, arterialization, and cardiac function in vivo, offering a next‐generation therapeutic strategy to overcome ...
Yu‐Jin Kim, Hyeok Kim, Dong‐Hyun Lee, Yeong Hwan Kim, Jae‐Hyun Park, Woo‐Sup Sim, Jin‐Ju Kim, Kiwon Ban, Soong Ho Um, Hyun Ji Park, Michael E. Davis, Hun‐Jun Park, Suk Ho Bhang   +12 more
wiley   +1 more source

Hidden pathway: the role of extracellular matrix in type 2 diabetes mellitus-related sarcopenia. [PDF]

Front Endocrinol (Lausanne)
Sun Y, Zhang Z, Wang Y, Wu X, Sun Y, Lou H, Xu J, Yao J, Cong D.   +8 more
europepmc   +1 more source