Results 291 to 300 of about 304,001 (345)

QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
High QSOX2 enhances stemness, drug resistance, and metastasis of ESCC cells. QSOX2‐mediated disulfide bond modification activates mTOR/c‐Myc signaling. CAFs‐secreted IGF‐1 drives mTOR/c‐Myc/QSOX2 positive feedback loop. Combining Ebselen, rapamycin, and cisplatin induces tumor dormancy in mice.
Wo‐Ming Chen, Xiao‐Ping Zhang, Xiao Sun, Hai‐Cheng Liu, Yuan‐Yuan Yan, Xue Wei, Yu Liang, Yue Feng, Zhengjie Chen, Yongxu Jia, Chen Jiang, Qian Yan, Lei Li   +12 more
wiley   +1 more source

3D Brain Vascular Niche Model Captures Glioblastoma Infiltration, Dormancy, and Gene Signatures

Advanced Science, EarlyView.
This study developed a 3D brain vascular niche model that capture the key features of glioblastoma including perivascular infiltration, gene signature, dormancy and chemo resistance, by comparing 3D model with in vivo condition using identical glioma stem cells.
Vivian K. Lee, Rut Tejero, Nathaniel Silvia, Anirudh Sattiraju, Aarthi Ramakrishnan, Li Shen, Alexandre Wojcinski, Santosh Kesari, Roland H. Friedel, Hongyan Zou, Guohao Dai   +10 more
wiley   +1 more source

Extracellular vesicles adhere to cells primarily by interactions of integrins and GM1 with laminin. [PDF]

J Cell Biol
Isogai T, Hirosawa KM, Kanno M, Sho A, Kasai RS, Komura N, Ando H, Furukawa K, Ohmi Y, Furukawa K, Yokota Y, Suzuki KGN.   +11 more
europepmc   +1 more source

Reinforcing Stromal Cell Spheroid Through Red‐Light Preconditioning for Advanced Vascularization

Advanced Science, EarlyView.
This study presents a novel approach to enhance stromal cell therapy for myocardial infarction by combining OLED‐based photobiomodulation (OPBM) preconditioning with 3D spheroid culture of hADSCs. The engineered spheroids improve angiogenesis, arterialization, and cardiac function in vivo, offering a next‐generation therapeutic strategy to overcome ...
Yu‐Jin Kim, Hyeok Kim, Dong‐Hyun Lee, Yeong Hwan Kim, Jae‐Hyun Park, Woo‐Sup Sim, Jin‐Ju Kim, Kiwon Ban, Soong Ho Um, Hyun Ji Park, Michael E. Davis, Hun‐Jun Park, Suk Ho Bhang   +12 more
wiley   +1 more source

The immune response against cancer is modulated by stromal cell fibronectin. [PDF]

Neoplasia
Lubosch A, Pitt L, Zoeller C, Wirth F, Exner T, Steigenberger B, Wabnitz G, Schroeder-Braunstein J, Nakchbandi IA.   +8 more
europepmc   +1 more source

Mechanical signaling regulates vascular smooth muscle cell adaptation in aging. [PDF]

Front Physiol
Mohajeri A, Shin SY, Padgham S, Boland DJ, Pittman Ratterree D, Blizman J, Han G, Woodman CR, Trache A.   +8 more
europepmc   +1 more source

Extracellular PDI in thrombosis and vascular injury. [PDF]

Thromb J
Wang J, Hogg PJ, Xu X, Fang C.
europepmc   +1 more source

ANGPTL4 promoted the cognitive impairment in vascular dementia via increasing integrin/p-Syk signalings induced mitochondrial autophagy and apoptosis in the hippocampus. [PDF]

Sci Rep
Yao C, Wang J.
europepmc   +1 more source

Interaction of <i>Serratia proteamaculans</i> with Integrins Activates Invasion-Promoting Signaling Pathways. [PDF]

Int J Mol Sci
Tsaplina O.
europepmc   +1 more source

Vedolizumab: Beyond Inflammatory Bowel Disease. [PDF]

Med Princ Pract
Li Y, Hu M, Chen Y, Yang XY, Wang Q, Ding J, Hu Y.   +6 more
europepmc   +1 more source