The characteristics and the multiple functions of integrin β1 in human cancers [PDF]
Journal of Translational Medicine, 2023 Integrins, which consist of two non-covalently linked α and β subunits, play a crucial role in cell–cell adhesion and cell-extracellular matrix (ECM) interactions.
Li Sun +3 more
doaj +3 more sources
Ligand-independent integrin β1 signaling supports lung adenocarcinoma development [PDF]
JCI Insight, 2022 Integrins — the principal extracellular matrix (ECM) receptors of the cell — promote cell adhesion, migration, and proliferation, which are key events for cancer growth and metastasis.
Scott M. Haake +22 more
doaj +3 more sources
Integrin β1 in Pancreatic Cancer: Expressions, Functions, and Clinical Implications. [PDF]
Cancers (Basel), 2022 Simple Summary Pancreatic cancer (PC) is a highly aggressive malignant tumor with an extremely poor prognosis. Early diagnosis and treatment are key to improving the survival rate of PC patients.
Li J +7 more
europepmc +2 more sources
Integrin β1 regulates the invasion and radioresistance of laryngeal cancer cells by targeting CD147
Cancer Cell International, 2018 Background Increased expression of integrin β1 has been reported to correlate with progression and therapy resistance in many types of cancers. The aim of this study was to investigate the effects of integrin β1 on the invasion and radioresistance of ...
Li Li, Xiaoxia Dong, Feng Peng, Li Shen
doaj +2 more sources
PACSIN2 regulates platelet integrin β1 hemostatic function. [PDF]
J Thromb Haemost, 2023 Biswas R +12 more
europepmc +2 more sources
Acetyl-NPKY of integrin-β1 binds KINDLIN2 to control endothelial cell proliferation and junctional integrity [PDF]
iScienceSummary: Integrin-dependent crosstalk between cell-matrix adhesions and cell-cell junctions is critical for controlling endothelial permeability and proliferation in cancer and inflammatory diseases but remains poorly understood.
Adama Sidibé +5 more
doaj +2 more sources
Vimentin-mediated buffering of internal integrin β1 pool increases survival of cells from anoikis [PDF]
BMC BiologyBackground The intermediate filament protein vimentin is widely recognized as a molecular marker of epithelial-to-mesenchymal transition. Although vimentin expression is strongly associated with cancer metastatic potential, the exact role of vimentin in ...
Jiyoung Jang +4 more
doaj +2 more sources
Vimentin tunes cell migration on collagen by controlling β1 integrin activation and clustering [PDF]
Journal of Cell Science, 2021 ABSTRACT Vimentin is a structural protein that is required for mesenchymal cell migration and directly interacts with actin, β1 integrin and paxillin. We examined how these interactions enable vimentin to regulate cell migration on collagen. In fibroblasts, depletion of vimentin increased talin-dependent activation of β1 integrin by more
Zofia Ostrowska-Podhorodecka +10 more
openaire +4 more sources
EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation
Nature Communications, 2021 Bone metastases occur in 50–70% of patients with late-stage breast cancers and effective therapies are needed. The expression of enhancer of zeste homolog 2 (EZH2) is correlated with breast cancer metastasis, but its function in bone metastasis hasn’t ...
Lin Zhang +10 more
semanticscholar +1 more source
Delayed cortical development in mice with a neural specific deletion of β1 integrin
Frontiers in Neuroscience, 2023 The adhesion systems employed by migrating cortical neurons are not well understood. Genetic deletion studies of focal adhesion kinase (FAK) and paxillin in mice suggested that these classical focal adhesion molecules control the morphology and speed of ...
Mamunur Rashid +2 more
doaj +1 more source