Results 1 to 10 of about 86,429 (265)

The primacy of β1 integrin activation in the metastatic cascade. [PDF]

PLoS ONE, 2012
After neoplastic cells leave the primary tumor and circulate, they may extravasate from the vasculature and colonize tissues to form metastases. β1 integrins play diverse roles in tumorigenesis and tumor progression, including extravasation.
Hisashi Kato, Zhongji Liao, John V Mitsios, Huan-You Wang, Elena I Deryugina, Judith A Varner, James P Quigley, Sanford J Shattil   +7 more
doaj   +3 more sources

The characteristics and the multiple functions of integrin β1 in human cancers [PDF]

Journal of Translational Medicine, 2023
Integrins, which consist of two non-covalently linked α and β subunits, play a crucial role in cell–cell adhesion and cell-extracellular matrix (ECM) interactions.
Li Sun, Shuwei Guo, Yiping Xie, Yongliang Yao   +3 more
doaj   +2 more sources

Cancer-specific cytotoxicity of curcumin through regulation of integrin β1 expression in colon cancer [PDF]

Scientific Reports
Curcumin has attracted attention for its nontoxic chemopreventive effects; however, the pathways underlying these effects in colon cancer remain unclear. We investigated the potential interplay between curcumin and integrin β1 in colon cancer.
Hyeon Kyeong Kim, Ryung-Ah Lee, Kyung Sook Hong, Gyoung Tae Noh, Bo Young Oh   +4 more
doaj   +2 more sources

Ligand-independent integrin β1 signaling supports lung adenocarcinoma development [PDF]

JCI Insight, 2022
Integrins — the principal extracellular matrix (ECM) receptors of the cell — promote cell adhesion, migration, and proliferation, which are key events for cancer growth and metastasis.
Scott M. Haake, Erin J. Plosa, Jonathan A. Kropski, Lindsay A. Venton, Anupama Reddy, Fabian Bock, Betty T. Chang, Allen J. Luna, Kateryna Nabukhotna, Zhi-Qi Xu, Rebecca A. Prather, Sharon Lee, Harikrishna Tanjore, Vasiliy V. Polosukhin, Olga M. Viquez, Angela Jones, Wentian Luo, Matthew H. Wilson, W. Kimryn Rathmell, Pierre P. Massion, Ambra Pozzi, Timothy S. Blackwell, Roy Zent   +22 more
doaj   +2 more sources

Acetyl-NPKY of integrin-β1 binds KINDLIN2 to control endothelial cell proliferation and junctional integrity [PDF]

iScience
Summary: Integrin-dependent crosstalk between cell-matrix adhesions and cell-cell junctions is critical for controlling endothelial permeability and proliferation in cancer and inflammatory diseases but remains poorly understood.
Adama Sidibé, Vasyl V. Mykuliak, Pingfeng Zhang, Vesa P. Hytönen, Jinhua Wu, Bernhard Wehrle-Haller   +5 more
doaj   +2 more sources

Vimentin-mediated buffering of internal integrin β1 pool increases survival of cells from anoikis [PDF]

BMC Biology
Background The intermediate filament protein vimentin is widely recognized as a molecular marker of epithelial-to-mesenchymal transition. Although vimentin expression is strongly associated with cancer metastatic potential, the exact role of vimentin in ...
Jiyoung Jang, Hyun Jung Park, Wonyoung Seong, Jiyoon Kim, Chungho Kim   +4 more
doaj   +2 more sources

PACSIN2 regulates platelet integrin β1 hemostatic function. [PDF]

J Thromb Haemost, 2023
Biswas R, Boyd EK, Eaton N, Steenackers A, Schulte ML, Reusswig F, Yu H, Drew C, Kahr WHA, Shi Q, Plomann M, Hoffmeister KM, Falet H.   +12 more
europepmc   +3 more sources

Integrin β1 activation induces an anti-melanoma host response. [PDF]

PLoS ONE, 2017
TGF-β is a cytokine thought to function as a tumor promoter in advanced malignancies. In this setting, TGF-β increases cancer cell proliferation, survival, and migration, and orchestrates complex, pro-tumorigenic changes in the tumor microenvironment ...
Laila Ritsma, Ipsita Dey-Guha, Nilesh Talele, Xavier Sole, Salony, Joeeta Chowdhury, Kenneth N Ross, Sridhar Ramaswamy   +7 more
doaj   +3 more sources

Delayed cortical development in mice with a neural specific deletion of β1 integrin

Frontiers in Neuroscience, 2023
The adhesion systems employed by migrating cortical neurons are not well understood. Genetic deletion studies of focal adhesion kinase (FAK) and paxillin in mice suggested that these classical focal adhesion molecules control the morphology and speed of ...
Mamunur Rashid, Mamunur Rashid, Eric C. Olson   +2 more
doaj   +1 more source

Osteocyte β1 integrin loss causes low bone mass and impairs bone mechanotransduction in mice

Journal of Orthopaedic Translation, 2022
Background: The key focal adhesion protein β1 integrin plays an essential role in early skeletal development. However, roles of β1 integrin expression in osteocytes during the regulation of bone homeostasis and mechanotransduction are incompletely ...
Lei Qin, Tailin He, Dazhi Yang, Yishu Wang, Zhenjian Li, Qinnan Yan, Peijun Zhang, Zecai Chen, Sixiong Lin, Huanqing Gao, Qing Yao, Zhen Xu, Bin Tang, Weihong Yi, Guozhi Xiao   +14 more
doaj   +1 more source