The linkage between β1 integrin and the actin cytoskeleton is differentially regulated by tyrosine and serine/threonine phosphorylation of β1 integrin in normal and cancerous human breast cells [PDF]
BMC Cell Biology, 2001 Background Structural requirements for the β1 integrin functions in cell adhesion, spreading and signaling have been well documented mainly for fibroblasts.
Takahashi Kazuhide
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β1 integrin–extracellular matrix interactions are essential for maintaining exocrine pancreas architecture and function [PDF]
Laboratory Investigation, 2013 Integrin receptors are responsible for integrating extracellular matrix signals inside the cell. The most prominent integrin receptor, β1 integrin, has a role in cell function, survival and differentiation. Recently, we demonstrated a profound in vivo role of β1 integrin expression in the pancreas on glucose homeostasis and islet function.
Riopel, Matthew M. +4 more
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Elucidation of the Roles of Tumor Integrin β1 in the Extravasation Stage of the Metastasis Cascade. [PDF]
Cancer Research, 2016 Tumor integrin β1 (ITGB1) contributes to primary tumor growth and metastasis, but its specific roles in extravasation have not yet been clearly elucidated.
Michelle B. Chen +4 more
semanticscholar +3 more sources
Neutralize the neutrophils! Neutrophil β1/β2 integrin activation contributes to JAK2-V617F–driven thrombosis [PDF]
Journal of Clinical Investigation, 2018 Barbui +4 more
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β1 integrin signaling maintains human epithelial progenitor cell survival in situ and controls proliferation, apoptosis and migration of their progeny. [PDF]
PLoS ONE, 2013 β1 integrin regulates multiple epithelial cell functions by connecting cells with the extracellular matrix (ECM). While β1 integrin-mediated signaling in murine epithelial stem cells is well-studied, its role in human adult epithelial progenitor cells ...
Nancy Ernst +6 more
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Integrin β1 and the Repair after Nervous System Injury
European Neurology, 2022 Background: Integrin β1, as a member of the adhesion molecule family, is widely distributed in many kinds of cells and participates in multiple biological functions of the nervous system, including cytoskeleton reorganization, axon growth, and ...
Lei Yan, Zhiming Cui
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BMC Cancer, 2021 Cancer development is strictly correlated to composition and physical properties of the extracellular matrix. Particularly, a higher matrix stiffness has been demonstrated to promote tumor sustained growth.
Changsong Wang +12 more
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Enhanced Expression of Integrin αvβ3 Induced by TGF-β Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF-β-Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells. [PDF]
, 2015 Epithelial-to-mesenchymal transition (EMT) plays a critical role in cancer metastasis, and is regulated by growth factors such as transforming growth factor β (TGF-β) and fibroblast growth factors (FGF) secreted from the stromal and tumor cells. However,
Hamada, Yoshinosuke +7 more
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Frontiers in Cell and Developmental Biology, 2021 Hepatocellular carcinoma (HCC) is a common malignancy worldwide, and the high ratio of recurrence and metastasis remains the main cause of its poor prognosis. Vascular invasion of HCC includes microvascular invasion (MVI) and portal vein tumor thrombosis
Xiaobo Zheng +12 more
semanticscholar +1 more source
Effective treatment of HER2-amplified breast cancer by targeting HER3 and β1 integrin [PDF]
Breast Cancer Research and Treatment, 2016 The central role of HER2 as the disease driver and HER3 as its essential partner has made them rational targets for the treatment of HER2-amplifed breast cancers, and there is considerable interest in developing highly effective treatment regimens for this disease that consist of targeted therapies alone.
Campbell, Marcia R +9 more
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