Enhanced Expression of Integrin αvβ3 Induced by TGF-β Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF-β-Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells. [PDF]
PLoS ONE, 2015 Epithelial-to-mesenchymal transition (EMT) plays a critical role in cancer metastasis, and is regulated by growth factors such as transforming growth factor β (TGF-β) and fibroblast growth factors (FGF) secreted from the stromal and tumor cells. However,
Seiji Mori +7 more
doaj +10 more sources
β1 integrin signaling maintains human epithelial progenitor cell survival in situ and controls proliferation, apoptosis and migration of their progeny. [PDF]
PLoS ONE, 2013 β1 integrin regulates multiple epithelial cell functions by connecting cells with the extracellular matrix (ECM). While β1 integrin-mediated signaling in murine epithelial stem cells is well-studied, its role in human adult epithelial progenitor cells ...
Nancy Ernst +6 more
doaj +1 more source
Effective treatment of HER2-amplified breast cancer by targeting HER3 and β1 integrin [PDF]
Breast Cancer Research and Treatment, 2016 The central role of HER2 as the disease driver and HER3 as its essential partner has made them rational targets for the treatment of HER2-amplifed breast cancers, and there is considerable interest in developing highly effective treatment regimens for this disease that consist of targeted therapies alone.
Campbell, Marcia R +9 more
openaire +4 more sources
A Receptor Integrin β1 Promotes Infection of Avian Metapneumovirus Subgroup C by Recognizing a Viral Fusion Protein RSD Motif. [PDF]
Int J Mol SciCui Y +10 more
europepmc +3 more sources
Regulation of Renin Expression by Β1-Integrin in As4.1 Juxtaglomerular Line Cells
Biomedicines, 2023 (1) Background: Renal dysfunction and hypertension are mutually aggravating factors; however, the details of their interaction remain unclear. In a study using renal tissue from diabetic rats, we found that β1-integrin, a cell-substrate adhesion molecule,
Nobumichi Saito +7 more
doaj +1 more source
β1-Integrin and integrin linked kinase regulate astrocytic differentiation of neural stem cells. [PDF]
PLoS ONE, 2014 Astrogliosis with glial scar formation after damage to the nervous system is a major impediment to axonal regeneration and functional recovery. The present study examined the role of β1-integrin signaling in regulating astrocytic differentiation of ...
Liuliu Pan +7 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 β1-integrin is a key receptor that regulates cell-ECM interactions and is important in maintaining mature beta-cell functions, including insulin secretion.
Malina Barillaro +5 more
doaj +1 more source
Calreticulin Regulates β1-Integrin mRNA Stability in PC-3 Prostate Cancer Cells
Biomedicines, 2022 Prostate cancer (PCa) is the major cause of cancer-related death among aging men worldwide. Recent studies have suggested that calreticulin (CRT), a multifunctional chaperon protein, may play an important role in the regulation of PCa tumorigenesis and ...
Yueh-Chien Lin +6 more
doaj +1 more source
Sharpin suppresses β1-integrin activation by complexing with the β1 tail and kindlin-1
Cell Communication and Signaling, 2019 Background Previously sharpin has been identified as an endogenous inhibitor of β1-integrin activation by directly binding to a conserved region in the cytoplasmic tails (CTs) of the integrin β1-associated α subunits. Methods Here we employed biochemical
Juan Gao +12 more
doaj +1 more source
Decreased integrin β1 in lipid raft inhibits proliferation and migration of HPS rat serum-induced PMVECs [PDF]
Jichu yixue yu linchuang, 2021 Objective To investigate the effects of integrin β1 within lipid raft on PMVECs. Methods PMVECs were divided into four groups: control group; HPS group: HPS; group and MβCD group: the cells were pretreated with 0.01 mol/L MβCD for 1 hour, and
GAO Jing, ZHOU Jia-qi
doaj