Results 21 to 30 of about 234,137 (355)
The primacy of β1 integrin activation in the metastatic cascade. [PDF]
PLoS ONE, 2012 After neoplastic cells leave the primary tumor and circulate, they may extravasate from the vasculature and colonize tissues to form metastases. β1 integrins play diverse roles in tumorigenesis and tumor progression, including extravasation.
Hisashi Kato +7 more
doaj +1 more source
β1-Integrin and integrin linked kinase regulate astrocytic differentiation of neural stem cells. [PDF]
PLoS ONE, 2014 Astrogliosis with glial scar formation after damage to the nervous system is a major impediment to axonal regeneration and functional recovery. The present study examined the role of β1-integrin signaling in regulating astrocytic differentiation of ...
Liuliu Pan +7 more
doaj +1 more source
Regulation of Renin Expression by Β1-Integrin in As4.1 Juxtaglomerular Line Cells
Biomedicines, 2023 (1) Background: Renal dysfunction and hypertension are mutually aggravating factors; however, the details of their interaction remain unclear. In a study using renal tissue from diabetic rats, we found that β1-integrin, a cell-substrate adhesion molecule,
Nobumichi Saito +7 more
doaj +1 more source
International Journal of Oncology, 2021 We previously reported that high expression of procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 (PLOD2) leads to stabilization and plasma membrane translocation of integrin β1 to promote the invasion and metastasis of oral squamous cell carcinoma (SCC).
Ken Saito +5 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2022 β1-integrin is a key receptor that regulates cell-ECM interactions and is important in maintaining mature beta-cell functions, including insulin secretion.
Malina Barillaro +5 more
doaj +1 more source
Integrin β1 regulates marginal zone B cell differentiation and PI3K signaling. [PDF]
J Exp Med, 2023 Marginal zone (MZ) B cells represent innate-like B cells that mediate a fast immune response. The adhesion of MZ B cells to the marginal sinus of the spleen is governed by integrins.
Andreani V +3 more
europepmc +3 more sources
Deficiency of 1 integrins results in increased myocardial dysfunction after myocardial infarction [PDF]
Heart, 2006 To study the role of beta1 integrins in left ventricular (LV) remodelling after myocardial infarction (MI).LV structural and functional alterations were determined in wild-type (WT) and beta1 integrin heterozygous knockout (hKO) mice one month after MI.
Krishnamurthy, P. +3 more
openaire +4 more sources
Calreticulin Regulates β1-Integrin mRNA Stability in PC-3 Prostate Cancer Cells
Biomedicines, 2022 Prostate cancer (PCa) is the major cause of cancer-related death among aging men worldwide. Recent studies have suggested that calreticulin (CRT), a multifunctional chaperon protein, may play an important role in the regulation of PCa tumorigenesis and ...
Yueh-Chien Lin +6 more
doaj +1 more source
Cells, 2021 Chondroitin sulfate (CS) is a major component of the extracellular matrix found to be abnormally accumulated in several types of cancer tissues. Previous studies have indicated that CS synthases and modification enzymes are frequently elevated in human ...
Yin-Hung Chu +5 more
semanticscholar +1 more source
β1 Integrins Modulate β-Adrenergic Receptor–Stimulated Cardiac Myocyte Apoptosis and Myocardial Remodeling [PDF]
Hypertension, 2007 Sympathetic nerve activity increases in the heart during cardiac failure. Here, we hypothesized that β1 integrins play a protective role in chronic β-adrenergic receptor–stimulated cardiac myocyte apoptosis and heart failure. l -isoproterenol (iso; 400 μg/kg per hour) was infused in a group of wild-type (WT) and β1 ...
Krishnamurthy, Prasanna +3 more
openaire +3 more sources