Results 31 to 40 of about 234,137 (355)

Decreased integrin β1 in lipid raft inhibits proliferation and migration of HPS rat serum-induced PMVECs [PDF]

Jichu yixue yu linchuang, 2021
Objective To investigate the effects of integrin β1 within lipid raft on PMVECs. Methods PMVECs were divided into four groups: control group; HPS group: HPS; group and MβCD group: the cells were pretreated with 0.01 mol/L MβCD for 1 hour, and
GAO Jing, ZHOU Jia-qi
doaj  

Sterile Inflammation Enhances ECM Degradation in Integrin β1 KO Embryonic Skin [PDF]

Cell Reports, 2016
Epidermal knockout of integrin β1 results in complete disorganization of the basement membrane (BM), resulting in neonatal lethality. Here, we report that this disorganization is exacerbated by an early embryonic inflammatory response involving the recruitment of tissue-resident and monocyte-derived macrophages to the dermal-epidermal junction ...
Kurbet, Ambika S, Hegde, Samarth, Bhattacharjee, Oindrila, Marepally, Srujan, Vemula, Praveen K, Raghavan, Srikala   +5 more
openaire   +5 more sources

Sharpin suppresses β1-integrin activation by complexing with the β1 tail and kindlin-1

Cell Communication and Signaling, 2019
Background Previously sharpin has been identified as an endogenous inhibitor of β1-integrin activation by directly binding to a conserved region in the cytoplasmic tails (CTs) of the integrin β1-associated α subunits. Methods Here we employed biochemical
Juan Gao, Yun Bao, Shushu Ge, Peisen Sun, Jiaojiao Sun, Jianmin Liu, Feng Chen, Li Han, Zhongyuan Cao, Jun Qin, Gilbert C. White, Zhen Xu, Yan-Qing Ma   +12 more
doaj   +1 more source

Integrin β1 orchestrates the abnormal cell-matrix attachment and invasive behaviour of E-cadherin dysfunctional cells

Gastric Cancer, 2021
Background Tumour progression relies on the ability of cancer cells to penetrate and invade neighbouring tissues. E-cadherin loss is associated with increased cell invasion in gastric carcinoma, and germline mutations of the E-cadherin gene are causative
J. Figueiredo, R. Ferreira, Han Xu, Margarida Gonçalves, André Barros-Carvalho, J. Cravo, A. Maia, Patrícia Carneiro, C. Figueiredo, Michael L. Smith, D. Stamenović, Eurico Morais-de-Sá, R. Seruca   +12 more
semanticscholar   +1 more source

WITHDRAWN: Galectin-3 carbohydrate recognition domain induces microvascular endothelial cell migration by activating β1 Integrin

Oncotarget, 2018
// Zhongyu Zhang 1 , Yuan Guan 1 , Xiyao Yu 1 , Hairong Cheng 1 , Yifa Zhou 1 and Guihua Tai 1 1 School of Life Sciences, Northeast Normal University, Changchun, PR China Correspondence to: Guihua Tai, email: taigh477@nenu.edu.cn Keywords : galectin-3; CRD; migration; HMEC-1; β1 integrin Received: August 18, 2017     Accepted ...
Zhongyu Zhang, Zhongyu Zhang, Yuan Guan, Yuan Guan, Xiyao Yu, Xiyao Yu, Hairong Cheng, Hairong Cheng, Yifa Zhou, Yifa Zhou, Guihua Tai, Guihua Tai   +11 more
openaire   +2 more sources

Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis [PDF]

, 2016
β1-Integrins are essential for angiogenesis. The mechanisms regulating integrin function in endothelial cells (EC) and their contribution to angiogenesis remain elusive.
Bennewitz, Katrin, Carmona, Guillaume, Chavakis, Emmanouil, Dimmeler, Stefanie, Gutkind, J. Silvio, Kroll, Jens, Li, Xuri, Manavski, Yosif, Sakurai, Atsuko, Tang, Zhongshu, Zeiher, Andreas M., Zhang, Fan   +11 more
core   +1 more source

Integrin β1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition

Cell Reports, 2021
At implantation, the embryo establishes contacts with the maternal endometrium. This stage is associated with a high incidence of preclinical pregnancy losses. While the maternal factors underlying uterine receptivity have been investigated, the signals required by the embryo for successful peri- implantation development remain elusive.
Magdalena Zernicka-Goetz, Magdalena Zernicka-Goetz, Antonia Weberling, Simon Fishel, Matteo A. Molè, Alison Campbell, Reinhard Fässler   +6 more
openaire   +7 more sources

Epidermal growth factor-mediated Rab25 pathway regulates integrin β1 trafficking in colon cancer

Cancer Cell International, 2018
Background Integrins play a critical role in carcinogenesis. Integrin β1 localization is regulated by the guanosine-5′-triphosphate hydrolase Rab25 and integrin β1 levels are elevated in the serum of colon cancer patients; thus, the present study ...
Kyung Sook Hong, Eun-Young Jeon, Soon Sup Chung, Kwang Ho Kim, Ryung-Ah Lee   +4 more
doaj   +1 more source

Human Parechovirus 1 Infection Occurs via αVβ1 Integrin. [PDF]

PLoS ONE, 2016
Human parechovirus 1 (HPeV-1) (family Picornaviridae) is a global cause of pediatric respiratory and CNS infections for which there is no treatment.
Pirjo Merilahti, Sisko Tauriainen, Petri Susi   +2 more
doaj   +1 more source

Integrin-Linked Kinase Is Required for TGF-β1 Induction of Dermal Myofibroblast Differentiation [PDF]

Journal of Investigative Dermatology, 2011
Cutaneous repair after injury requires activation of resident dermal fibroblasts and their transition to myofibroblasts. The key stimuli for myofibroblast formation are activation of transforming growth factor-β (TGF-β) receptors and mechanotransduction mediated by integrins and associated proteins.
Vi, Linda, De Lasa, Cristina, Diguglielmo, Gianni M., Dagnino, Lina   +3 more
openaire   +6 more sources