Diagnostic Performance of a Novel CXCL10 mRNA Release Assay for Mycobacterium tuberculosis Infection
Frontiers in Microbiology, 2022 One-fourth of the world’s population has been infected with Mycobacterium tuberculosis (M.tb). Although interferon-gamma release assays (IGRAs) have been shown to be valid methods for identifying M.tb infection and auxiliary methods for diagnosis of ...
Liping Pan +17 more
doaj +1 more source
Tricks to translating TB transcriptomics. [PDF]
, 2015 Transcriptomics and other high-throughput methods are increasingly applied to questions relating to tuberculosis (TB) pathogenesis. Whole blood transcriptomics has repeatedly been applied to define correlates of TB risk and has produced new insight into ...
Coussens, AK, Deffur, A, Wilkinson, RJ
core +1 more source
[Interferon-gamma release assays in tuberculosis diagnostics]
Der Internist, 2007 Two years ago, CE certified interferon-gamma release assays (IGRA) were launched on the German market (QuantiFERON-TB Gold In-Tube and T-SPOT-TB). Since this time, a multitude of studies have analysed these assays. Guidelines have been elaborated by national expert committees of England, the USA and Switzerland.
Hoffmann, H, Loytved, G, Bodmer, T
openaire +3 more sources
Hemodialysis acutely altered interferon-gamma release assay test result and immune cell profile
Journal of Microbiology, Immunology and Infection, 2022 Patients receiving hemodialysis (HD) are at risk of TB development. IGRA-positive patients showed significant decrease in quantitative IGRA result with alterations in CD3+CD4+CD45RO+, NK cell, and monocyte subsets immediately upon HD procedure.
Denise Utami Putri +8 more
doaj +1 more source
The potential role of T-cells and their interaction with antigen-presenting cells in mediating immunosuppression following trauma-hemorrhage [PDF]
, 2009 Objective: Trauma-hemorrhage results in depressed immune responses of antigen-presenting cells (APCs) and T-cells. Recent studies suggest a key role of depressed T-cell derived interferon (IFN)-g in this complex immune cell interaction.
Abraham E. +15 more
core +1 more source
Chinese Medical Journal, 2018 Background: Interferon-gamma release assay (IGRA) has been used in latent tuberculosis (TB) infection and TB diagnosis, but the results from different high TB-endemic countries are different.
Wan-Li Kang +10 more
doaj +1 more source
Performance of an interferon-γ release assay-based test for cell-mediated immunity to SARS-CoV-2
Frontiers in Immunology, 2023 In search for immunological correlates of protection against acute coronavirus disease 2019 (COVID-19) there is a need for high through-put assays for cell-mediated immunity (CMI) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Luís Fonseca Brito +16 more
doaj +1 more source
Diagnosis of childhood tuberculosis and host RNA expression in Africa [PDF]
, 2014 Improved diagnostic tests for tuberculosis in children are needed. We hypothesized that transcriptional signatures of host blood could be used to distinguish tuberculosis from other diseases in African children who either were or were not infected with ...
Amelia C. Crampin +26 more
core +5 more sources
Performance of commerical blood tests for the diagnosis of latent tuberculosis infection in children and adolescents [PDF]
, 2009 BACKGROUND: The accurate diagnosis of latent tuberculosis infection reduces the risk of progression to severe disseminated disease. However, in young children, a major limitation of the standard tuberculin skin test is that false-negative results cannot ...
B. Meccugni +10 more
core +1 more source
Molecular mechanisms of IL-18BP regulation in DLD-1 cells: pivotal direct action of the STAT1/GAS axis on the promoter level [PDF]
, 2008 Interleukin (IL)-18, formerly known as interferon (IFN)-γ-inducing factor, is a crucial mediator of host defence and inflammation. Control of IL-18 bioactivity by its endogenous antagonist IL-18 binding protein (IL-18BP) is a major objective of ...
Bachmann, Malte +3 more
core +1 more source