Results 41 to 50 of about 116,104 (295)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Tuberculosis in Children: New diagnostic Blood Tests

Canadian Journal of Infectious Diseases and Medical Microbiology, 2010
The interferon-gamma-release assays were developed to overcome the pitfalls and logistic difficulties of the tuberculin skin test (TST) for the diagnosis of latent tuberculosis infection (LTBI).
F Kakkar, UD Allen, D Ling, M Pai, IC Kitai   +4 more
doaj   +1 more source

Four Patients with COVID-19 and Tuberculosis, Singapore, April–May 2020

Emerging Infectious Diseases, 2020
Coronavirus disease (COVID-19) and tuberculosis (TB) developed in 4 foreign workers living in dormitories in Singapore during April–May 2020. Clinical manifestations and atypical radiographic features of COVID-19 led to the diagnosis of TB through ...
Sai Meng Tham, Wei Yang Lim, Chun Kiat Lee, Jerold Loh, Arthi Premkumar, Benedict Yan, Adrian Kee, Louis Chai, Paul Anantharajah Tambyah, Gabriel Yan   +9 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Recombinant gamma interferon induces hypertriglyceridemia and inhibits post-heparin lipase activity in cancer patients. [PDF]

, 1986
Animals suffering from malignancy or chronic infection develop characteristic metabolic abnormalities, including a well-defined hypertriglyceridemic state.
Bradley, WA, Gianturco, SH, Gutterman, JU, Kurzrock, R, Quesada, JR, Rohde, MF, Sherwin, SA   +6 more
core  

Latent Tuberculosis Infection among Healthcare Students and Postgraduates in a Mediterranean Italian Area: What Correlation with Work Exposure? [PDF]

, 2019
Background: Tuberculosis screening is part of the standard protocol for evaluating the risk of infection in healthcare workers. The aim of this study was to evaluate the prevalence of latent tuberculosis infection (LTBI) among students attending various ...
Antonina Ciccarello, Benedetta Romanin, Maria Gabriella Verso, Nicola Serra, Paola Di Carlo   +4 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Accuracy of the interferon-gamma release assay for the diagnosis of tuberculous pleurisy: an updated meta-analysis [PDF]

PeerJ, 2015
Background and Objectives. The best method for diagnosing tuberculous pleurisy (TP) remains controversial. Since a growing number of publications focus on the interferon-gamma release assay (IGRA), we meta-analyzed the available evidence on the overall ...
Cai-Shuang Pang, Yong-Chun Shen, Pan-Wen Tian, Jing Zhu, Mei Feng, Chun Wan, Fu-Qiang Wen   +6 more
doaj   +2 more sources

The seasonality of tuberculosis, sunlight, vitamin D, and household crowding. [PDF]

, 2014
BACKGROUND: Unlike other respiratory infections, tuberculosis diagnoses increase in summer. We performed an ecological analysis of this paradoxical seasonality in a Peruvian shantytown over 4 years. METHODS: Tuberculosis symptom-onset and diagnosis dates
Adams, Akhtar, Ane-Anyangwe, Anibarro, Arnedo-Pena, Baker, C. A. Evans, C. Jongkaewwattana, Chew, Dowling, Drucker, E. S. Ramos, Ford, G. Sandhu, J. J. Lewis, J. S. Friedland, K. Zevallos, Kennel, Liu, Lonnroth, Luquero, M. A. Tovar, M. R. Baldwin, Martineau, Nagayama, Onifade, Parrinello, R. H. Gilman, R. Montoya, Rao, Rook, S. G. Schumacher, Schaaf, Stamp, T. Wingfield, ten Asbroek, Wilkinson, Yang, Yoshiyama   +38 more
core   +2 more sources

Miliary Tuberculosis with Indeterminate Interferon Gamma Release Assay Results

Internal Medicine, 2013
Recently, interferon gamma release assays (IGRAs) have become an important clinical tool for detecting latent tuberculosis. However, IGRA results may impede making a diagnosis. We herein present an interesting case of miliary tuberculosis with a nonspecific IGRA reaction due to hemophagocytosis.
Takahito, Nei, Yousuke, Fujisawa, Yuuki, Izumi, Akito, Tetsuka, Yosie, Arita, Hiroshige, Murata, Keisuke, Sawai, Mitsunobu, Kitamura, Hideki, Miyachi, Yusuke, Hosokawa, Koichi, Akutsu, Takeshi, Yamamoto, Keiji, Tanaka, Akihiro, Shinoyama   +13 more
openaire   +3 more sources