Results 191 to 200 of about 260,978 (210)

Type III Interferons (Lambda Interferons) in Rheumatic Autoimmune Diseases

Archivum Immunologiae et Therapiae Experimentalis, 2020
The last 2 decades have witnessed the discovery and characterization of a new family of cytokines with immunological characteristics similar to those described for type I interferons, type III or lambda interferons. Unraveling the molecular mechanisms underlying each type of interferon has allowed us to understand how some autoimmune diseases can be ...
Tania Mora-Arias, Luis M. Amezcua-Guerra
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Interferon lambda as a potential treatment for COVID-19

Expert Opinion on Biological Therapy, 2023
Pegylated interferon lambda substantially reduced the risk of COVID-19-related hospitalizations or emergency room visits in a recent phase 3, multi-center, randomized, double-blind, placebo-controlled study of high-risk, non-hospitalized adult patients with SARS-CoV-2 infection compared to treatment with placebo.Interferons are a family of signaling ...
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Meeting Overview: Interferon Lambda—Disease Impact and Therapeutic Potential [PDF]

Journal of Interferon and Cytokine Research, 2019
A meeting entitled, Interferon Lambda: Disease Impact and Translational Potential, was held on the campus of the National Institutes of Health in Bethesda, Maryland, on October 25-26, 2018.
Raymond Donnelly, Howard A Young, Ludmila Prokunina-Olsson   +2 more
exaly   +1 more source

Interferon Lambda: Toward a Dual Role in Cancer

Journal of Interferon & Cytokine Research, 2019
Interferon (IFN)-λ, a type III interferon (IFN), is a member of a new family of pleotropic cytokines that share high similarity with classical IFNs α and β (IFN-α/β), type I IFNs. IFN-λ acts as an antiviral agent and displays distinct biological functions, including tumor suppression.
Ahmed, Lasfar, Andrew, Zloza, Ann W, Silk, Leonard Y, Lee, Karine A, Cohen-Solal   +4 more
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Interferon-lambda serum levels in hepatitis C

Journal of Hepatology, 2011
Dendritic cells (DCs) trigger adaptive immune responses and are an important source of antiviral cytokines. In hepatitis C virus (HCV) infection DC function is markedly impaired. Thus far, studies have focused on types I and II interferon (IFN). We studied IFN-lambda1 (IL-29) and IFN-lambda2/3 (IL-28A/B) serum levels in patients with different outcomes
Bettina, Langhans, Bernd, Kupfer, Ingrid, Braunschweiger, Simone, Arndt, Wibke, Schulte, Hans Dieter, Nischalke, Jacob, Nattermann, Johannes, Oldenburg, Tilman, Sauerbruch, Ulrich, Spengler   +9 more
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Evolutionary insights of interferon lambda genes in tetrapods

Journal of Evolutionary Biology
Abstract Type III interferon (IFN), also known as IFN-λ, is an innate antiviral protein. We retrieved the sequences of IFN-λ and their receptors from 42 tetrapod species and conducted a computational evolutionary analysis to understand the diversity of these genes.
Devika Gautam, Anil Sindhu, Ashutosh Vats, Shiveeli Rajput, Chanchal Rana, Sachinandan De   +5 more
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Interferon Lambda as a Potential New Therapeutic for Hepatitis C

Annals of the New York Academy of Sciences, 2009
Interferon lambdas (IFN‐λ) are Type III interferons with biological activity, including induction of antiviral genes, similar to Type I IFNs, but signal through a distinct receptor complex. The expression pattern for the IFN‐λ receptor is more cell specific than the widely distributed IFN‐α receptor, suggesting in vivo, IFN‐λ may have fewer side ...
Dennis M, Miller, Kevin M, Klucher, Jeremy A, Freeman, Diana F, Hausman, David, Fontana, Doug E, Williams   +5 more
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Interferon-Lambda as a Potential Therapeutic Agent in Cancer Treatment

Journal of Interferon & Cytokine Research, 2010
The discovery that type I interferon (IFN-alpha/beta) inhibited tumor cell growth was welcomed initially with great excitement as it rapidly became a U.S. Food and Drug Administration-approved drug to treat several forms of cancer. In time, this enthusiasm diminished as severe toxicity associated with IFN-alpha administration, resistance to the therapy,
Håkan C, Steen, Ana M, Gamero
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Interferon lambda polymorphisms: validation and characterisation

2017
Polymorphisms in the interferon lambda (IFNλ) gene cluster have been shown to influence spontaneous and treatment induced clearance of hepatitis C virus (HCV) infection. The most studied single nucleotide polymorphism (SNP), rs12979860, lies within the first intron of IFNλ4, though is still commonly referred to as IFNλ3.
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Interferon lambda promotes immune dysregulation and tissue inflammation in TLR7-induced lupus

Proceedings of the National Academy of Sciences of the United States of America, 2020
Sergei Kotenko, Xinghao Wang, Jeffrey Kopp   +2 more
exaly