Increased cGAS/STING signaling components in patients with Mooren’s ulcer [PDF]
International Journal of Ophthalmology, 2021 AIM: To explore the expression of cGAS/STING signaling components in Mooren's ulcer (MU). METHODS: Samples were obtained from ten MU patients, and eight residual corneal-scleral rings of healthy donor corneas for controls. Human corneal epithelial cells (
Ya-Ni Zhang +8 more
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Interferon regulatory factor 3 is a potential biomarker to predict the process of atherosclerosis [PDF]
BIO Web of Conferences, 2023 Cardiovascular diseases is one of the major public health and medical concerns globally. Atherosclerosis is a condition where plaque build-up narrows the blood vessels, ultimately preventing sufficient blood flow to the heart.
Lu Shynie
doaj +1 more source
Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Animal Science and Biotechnologies, 2021 IRF3 has gained recognition as a key transcriptional regulator of type1 interferon (IFN) gene expression which induces response to pathogenic infection.
Sanda MOFOYEKE +4 more
doaj +1 more source
Opposing roles for interferon regulatory factor-3 (IRF-3) and type I interferon signaling during plague. [PDF]
PLoS Pathogens, 2012 Type I interferons (IFN-I) broadly control innate immunity and are typically transcriptionally induced by Interferon Regulatory Factors (IRFs) following stimulation of pattern recognition receptors within the cytosol of host cells.
Ami A Patel +4 more
doaj +1 more source
Pestivirus Npro Directly Interacts with Interferon Regulatory Factor 3 Monomer and Dimer. [PDF]
J Virol, 2016 UNLABELLED Interferon regulatory factor 3 (IRF3) is a transcription factor involved in the activation of type I alpha/beta interferon (IFN-α/β) in response to viral infection.
Gottipati K +3 more
europepmc +3 more sources
Frontiers in Oncology, 2020 Among the childhood diseases, B-cell acute lymphocytic leukemia (B-ALL) is the most frequent type of cancer. Despite recent advances concerning disease treatment, cytotoxic chemotherapy remains the first line of treatment in several countries, and the ...
Geise Ellen Broto +12 more
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Human Norovirus NTPase Antagonizes Interferon-β Production by Interacting With IkB Kinase ε
Frontiers in Microbiology, 2021 Human norovirus (HuNoV) is the leading cause of epidemic acute gastroenteritis worldwide. Type I interferons (IFN)-α/β are highly potent cytokines that are initially identified for their essential roles in antiviral defense.
Zifeng Zheng +10 more
doaj +1 more source
LGP2 expression is enhanced by interferon regulatory factor 3 in olive flounder, Paralichthys olivaceus. [PDF]
PLoS ONE, 2012 In innate immunity, LGP2 (laboratory of genetics and physiology 2) plays a very important role in the production of type I interferon (IFN) through recognition of cytosolic viral RNA.
Jun-Ichi Hikima +9 more
doaj +1 more source
Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection [PDF]
, 2012 Abnormal prion protein (PrP Sc) generated from the cellular isoform of PrP (PrP C) is assumed to be the main or sole component of the pathogen, called prion, of transmissible spongiform encephalopathies (TSE).
Yamaguchi, Naohiro +7 more
core +1 more source
Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA [PDF]
, 2009 U1-snRNA is an integral part of the U1 ribonucleoprotein pivotal for pre-mRNA splicing. Toll-like receptor (TLR) signaling has recently been associated with immunoregulatory capacities of U1-snRNA.
Pfeilschifter, Josef (Prof. Dr.) +3 more
core +1 more source