Results 1 to 10 of about 22,722 (130)

Foot-and-mouth disease virus VP4 interferes with host interferon response by targeting the nuclear translocation of interferon regulatory factor 3 (IRF3) [PDF]

Veterinary Research
Upon RNA virus infection, nuclear translocation of activated transcriptional factors via the RNA-sensing signal pathway is a key event in the interferon (IFN)-mediated antiviral response, and a specific target of viral immune evasion.
Ashan Subasinghe, N. A. Nadeeka Nethmini, Asela Weerawardhana, Nuwan Gamage, D. K. Haluwana, Jong-Soo Lee   +5 more
doaj   +4 more sources

Analysis of Tissue-Specific Interferon Regulatory Factor 3 (IRF3) Gene Expression against Viral Infection in Paralichthys olivaceus. [PDF]

Dev Reprod, 2021
Interferon Regulatory Factor 3 (IRF3) is a member of interferon-regulated transcription factor family and is known to play an important role in the innate immune response against viral infections. In this study, the expression of IRF3 in different tissues, developmental stages, and stocking densities of olive flounder was investigated.
Kim KH, Lee S, Park JW, Jung HS, Kim J, Yang H, Lee JH, Lee D.   +7 more
europepmc   +4 more sources

Interferon Regulatory Factor 3 (IRF3) Characterisation in Four Mammalian Species Using Bioinformatics Method

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Animal Science and Biotechnologies, 2021
IRF3 has gained recognition as a key transcriptional regulator of type1 interferon (IFN) gene expression which induces response to pathogenic infection.
Sanda MOFOYEKE, Adenaike ADEYEMI, Fafiolu ADEBOYE, Adeyinka SANDA, Christian IKEOBI   +4 more
doaj   +3 more sources

Interferon regulatory factor 3-CL, an isoform of IRF3, antagonizes activity of IRF3 [PDF]

Cellular and Molecular Immunology, 2010
Interferon regulatory factor 3 (IRF3), one member of the IRF family, plays a central role in induction of type I interferon (IFN) and regulation of apoptosis. Controlled activity of IRF3 is essential for its functions. During reverse transcription (RT)-PCR to clone the full-length open reading frame (ORF) of IRF3, we cloned a full-length ORF encoding ...
Chunhua, Li, Lixin, Ma, Xinwen, Chen
exaly   +3 more sources

Identification of a Novel in Vivo Virus-targeted Phosphorylation Site in Interferon Regulatory Factor-3 (IRF3)* [PDF]

Journal of Biological Chemistry, 2010
The transcription factor interferon regulatory factor-3 (IRF3) regulates expression of type I interferon-beta and plays an important role in antiviral immunity. Despite the biological importance of IRF3, its in vivo phosphorylation pattern has not been reported.
Ingvild B Johnsen, Lars Hagen, Geir Slupphaug   +2 more
exaly   +3 more sources

Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels. [PDF]

Nat Commun
AbstractObesity-induced inflammation causes metabolic dysfunction, but the mechanisms remain elusive. Here we show that the innate immune transcription factor interferon regulatory factor (IRF3) adversely affects glucose homeostasis through induction of the endogenous FAHFA hydrolase androgen induced gene 1 (AIG1) in adipocytes.
Yan S, Santoro A, Niphakis MJ, Pinto AM, Jacobs CL, Ahmad R, Suciu RM, Fonslow BR, Herbst-Graham RA, Ngo N, Henry CL, Herbst DM, Saghatelian A, Kahn BB, Rosen ED.   +14 more
europepmc   +4 more sources

TRIM59 promotes immune evasion and tumor progression in lung adenocarcinoma via ubiquitin- proteasomal degradation of IRF3 [PDF]

Frontiers in Immunology
Lung adenocarcinoma (LUAD) remains a leading cause of cancer-related mortality, with immune evasion being a key driver of treatment resistance and poor prognosis.
Xue Li, Meifang Guo, Zhen Lian
doaj   +2 more sources

Identification of polymorphisms and genetic diversity studies of interferon regulatory factor 3(IRF3) gene in Muturu,White Fulani and N’Dama cattle

Tropical Animal Health and Production
Abstract Interferon regulatory factor 3 (IRF3) is one of the strongest positional candidate genes implicated in a host of health-related phenotypes such as general disease resistance. The study was carried out to genetically characterize the IRF3 gene in the, N’Dama, Muturu and White Fulani cattle. DNA was extracted from the blood samples using
Samuel Olutunde Durosaro, Abubakar Akinfolarin Mohammed   +1 more
exaly   +3 more sources

IRF3-binding lncRNA-ISIR strengthens interferon production in viral infection and autoinflammation

Cell Reports, 2021
Summary: Interferon regulatory factor 3 (IRF3) is an essential transductor for initiation of many immune responses. Here, we show that lncRNA-ISIR directly binds IRF3 to promote its phosphorylation, dimerization, and nuclear translocation, along with ...
Junfang Xu, Pin Wang, Zemeng Li, Zhiqing Li, Dan Han, Mingyue Wen, Qihang Zhao, Lianfeng Zhang, Yuanwu Ma, Wei Liu, Minghong Jiang, Xuan Zhang, Xuetao Cao   +12 more
doaj   +1 more source

INPP5D inhibits anti-malarial immunity by promoting IRF3 degradation through selective autophagy

Autophagy Reports, 2023
As a member of the inositol polyphosphate-5-phosphatase family, INPP5D (inositol polyphosphate-5-phosphatase D) is an important regulator of immune cell activation. To date, the mechanisms underlying anti-malarial immunity have not been elucidated.
Hongyu Li, Xiao Yu
doaj   +1 more source