Results 41 to 50 of about 22,608,904 (223)

The effect of interferon on the transcription pattern of parainfluenza virus 5 [PDF]

, 2013
Interferon (IFN) is activated in response to virus infections and upregulates interferon-stimulated genes (ISGs) resulting in the expression of hundreds of proteins, many of which have direct or indirect antiviral activity.
Norsted, Hanna
core   +2 more sources

TRIM65 regulates innate immune signaling by enhancing K6-linked ubiquitination of IRF3 and its chromatin recruitment

Cell Reports
Summary: Viral infection triggers a rapid and effective cellular response primarily mediated by interferon β (IFNβ), which induces an antiviral state through complex signaling cascades.
Danae Fonseca, Giuseppe Pisanelli, Rocío Seoane, Lisa Miorin, Adolfo García-Sastre   +4 more
doaj   +1 more source

Foot-and-Mouth Disease Virus Capsid Protein VP1 Antagonizes TPL2-Mediated Activation of the IRF3/IFN-β Signaling Pathway to Facilitate the Virus Replication

Frontiers in Immunology, 2021
Foot-and-mouth disease (FMD) is a severe, highly contagious viral disease of cloven-hoofed animals. In order to establish an infection, the FMD virus (FMDV) needs to counteract host antiviral responses.
Junhong Hao, Chaochao Shen, Nannan Wei, Minghao Yan, Xuegang Zhang, Guowei Xu, Dajun Zhang, Jing Hou, Weijun Cao, Ye Jin, Keshan Zhang, Haixue Zheng, Xiangtao Liu   +12 more
doaj   +1 more source

Deep sequencing analysis of defective genomes of parainfluenza virus 5 and their role in interferon induction [PDF]

, 2013
This work was supported by The Wellcome Trust (087751/A/08/Z).Preparations of parainfluenza virus 5 (PIV5) that are potent activators of the interferon (IFN) induction cascade were generated by high-multiplicity passage in order to accumulate defective ...
Killip, M. J., Davison, A. J., Young, D.F., Goodbourn, S., Ross, C.S., Young, D. F., Davison, A.J., Short, J.A.L., Ross, C. S., Randall, R. E., Gatherer, D., Short, J. A. L., Killip, M.J., Randall, R.E.   +13 more
core   +1 more source

Generation of replication-proficient Influenza Virus NS1 point mutants with interferon-hyperinducer phenotype [PDF]

, 2014
The NS1 protein of influenza A viruses is the dedicated viral interferon (IFN)-antagonist. Viruses lacking NS1 protein expression cannot multiply in normal cells but are viable in cells deficient in their ability to produce or respond to IFN.
Fernández, Yolanda, Juan Ortín, Randall, Richard E, Richard E. Randall (190211), Killip, Marian J, Víctor J Asensio, Bengoechea, José A, Pérez-Cidoncha, M, Marian J. Killip (571160), Marian J Killip, Maite Pérez-Cidoncha (195699), Ortín, Juan, Killip, MJ, Ortín, J, Richard E Randall, Juan Ortín (5649007), Yolanda Fernández, Fernández, Y, Asensio, Víctor J, Randall, RE, José A Bengoechea, José A. Bengoechea (124595), Pérez-Cidoncha, Maite, Bengoechea, JA, Víctor J. Asensio (571161), Bengoechea, José A; id_orcid, Maite Pérez-Cidoncha, Asensio, VJ, Yolanda Fernández (268684), Bengoechea, Jose Antonio, Asensio, Víctor José, Randall, Richard E.   +31 more
core   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

The Molecular Mechanism of Herpes Simplex Virus 1 UL31 in Antagonizing the Activity of IFN-β

Microbiology Spectrum, 2022
Virus infection triggers intricate signal cascade reactions to activate the host innate immunity, which leads to the production of type I interferon (IFN-I).
Lan Gong, Xiaowen Ou, Li Hu, Jiayi Zhong, Jingjing Li, Shenyu Deng, Bolin Li, Lingxia Pan, Liding Wang, Xuejun Hong, Wenqi Luo, Qiyuan Zeng, Jie Zan, Tao Peng, Mingsheng Cai, Meili Li   +15 more
doaj   +1 more source

Autophagic checks and balances of cellular immune responses

Autophagy Reports, 2022
IRF3 (interferon regulatory factor 3) is a critical component of the antiviral innate immune response. IRF3 deficiency causes detrimental effects to the host during virus infection.
Sukanya Chakravarty, Shumin Fan, Ritu Chakravarti, Saurabh Chattopadhyay   +3 more
doaj   +1 more source

IFN regulatory factor 3 of golden pompano and its NLS domain are involved in antibacterial innate immunity and regulate the expression of type I interferon (IFNa3)

Frontiers in Immunology, 2023
IntroductionThe transcription factor interferon regulatory factor 3 (IRF3) plays an important role in host defence against viral infections. However, its role during bacterial infection in teleosts remains unclear.
Yun Sun, Yun Sun, Zhenjie Cao, Zhenjie Cao, Panpan Zhang, Panpan Zhang, Caoying Wei, Caoying Wei, Jianlong Li, Jianlong Li, Ying Wu, Ying Wu, Yongcan Zhou, Yongcan Zhou   +13 more
doaj   +1 more source