Results 31 to 40 of about 22,608,904 (223)

SARS-CoV-2 Spike Antagonizes Innate Antiviral Immunity by Targeting Interferon Regulatory Factor 3

Frontiers in Cellular and Infection Microbiology, 2022
Corona virus disease 2019 (COVID-19) pathogenesis is intimately linked to the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) and disease severity has been associated with compromised induction of type I interferon (IFN-I) cytokines which ...
Raul S. Freitas, Tyler F. Crum, Kislay Parvatiyar   +2 more
doaj   +1 more source

Viral interferon antagonists and antiviral drugs [PDF]

, 2009
For this project, we developed reporter cell lines that express viral proteins with the potential to be used in cell-based screening assays to select chemical candidates for antiviral drugs.
Nobre, Rita
core   +2 more sources

Cellular localization of the herpes simplex virus ICP0 protein dictates its ability to block IRF3-mediated innate immune responses. [PDF]

PLoS ONE, 2010
Interferon regulatory factor 3 (IRF3) is important for innate antiviral responses; accordingly, many viruses target and inactivate IRF3. The ability of the Herpes simplex virus type 1 (HSV-1) immediate early protein ICP0 to inhibit IRF3 is controversial ...
Patrick Paladino, Susan E Collins, Karen L Mossman   +2 more
doaj   +1 more source

A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity

Cell Reports, 2023
Summary: The regulation of antiviral immunity is crucial in maintaining host immune homeostasis, a process that involves dynamic modulations of host organelles.
Mengyuan Zhao, Yong Zhang, Lihua Qiang, Zhe Lu, Zhuo Zhao, Yesheng Fu, Bo Wu, Qiyao Chai, Pupu Ge, Zehui Lei, Xinwen Zhang, Bingxi Li, Jing Wang, Lingqiang Zhang, Cui Hua Liu   +14 more
doaj   +1 more source

Mutations in SARS-CoV-2 ORF8 Altered the Bonding Network With Interferon Regulatory Factor 3 to Evade Host Immune System

Frontiers in Microbiology, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been continuously mutating since its first emergence in early 2020. These alterations have led this virus to gain significant difference in infectivity, pathogenicity, and host immune ...
Farooq Rashid, Farooq Rashid, Muhammad Suleman, Abdullah Shah, Emmanuel Enoch Dzakah, Emmanuel Enoch Dzakah, Haiying Wang, Shuyi Chen, Shixing Tang, Shixing Tang, Shixing Tang   +10 more
doaj   +1 more source

Rotavirus capping enzyme VP3 inhibits interferon expression by inducing MAVS degradation during viral replication

mBio, 2023
The binding of viral RNA to RIG-I-like receptors triggers the formation of mitochondrial antiviral signaling (MAVS) protein aggregates critical for interferon (IFN) expression.
Jin Dai, Chantal A. Agbemabiese, Ashley N. Griffin, John T. Patton   +3 more
doaj   +1 more source

CuRTAiling Interferon Regulatory Factor Signaling with the E3 Ligase RAUL [PDF]

, 2010
Interferon regulatory factor 3 (IRF3) and IRF7 modulate the transcription of type I interferon. In this issue of Immunity, Yu and Hayward (2010) identify RAUL, the bona fide ubiquitin ligase that regulates turnover of IRF3 and ...
Hiscott, John, Suzanne Paz, Paz, Suzanne, John Hiscott   +3 more
core   +1 more source

Interferon Regulatory Factor 3 Deficiency Induces Age-Related Alterations of the Retina in Young and Old Mice

Frontiers in Cellular Neuroscience, 2019
Age-related changes in visual function and retina structure are very common in aged animals, but the underlying mechanisms of these changes remain unclear.
Xi Zhang, Jingyi Zhu, Xianjun Chen, Zhang Jie-Qiong, Xue Li, Linlin Luo, Huang Huang, Wenyi Liu, Xinyuan Zhou, Jun Yan, Sen Lin, Jian Ye   +11 more
doaj   +1 more source

The N-terminus of Bunyamwera orthobunyavirus NSs protein is essential for interferon antagonism [PDF]

, 2010
This work is supported by UK MRC and BBRCBunyamwera virus NSs protein is involved in the inhibition of cellular transcription and the interferon (IFN) response, and it interacts with the Med8 component of Mediator.
Van Knippenberg, Ingeborg Christine, Carlton-Smith, C., Carlton-Smith, Charles, Elliott, Richard Michael, van Knippenberg, I., Elliott, R.M.   +5 more
core   +1 more source

Bunyaviruses and the type I interferon system [PDF]

, 2009
The family Bunyaviridae contains more than 350 viruses that are distributed throughout the world. Most members of the family are transmitted by arthopods, and several cause disease in man, domesticated animals and crop plants. Despite being recognized as
Richard M. Elliott, Weber, F., Richard Elliott, Richard M. Elliott, Elliott, Richard Michael, Friedemann Weber, Weber, F, Elliott, R.M.   +7 more
core   +1 more source