Results 11 to 20 of about 22,608,904 (223)
Influenza A Virus PA Antagonizes Interferon-β by Interacting with Interferon Regulatory Factor 3 [PDF]
Frontiers in Immunology, 2017 The influenza A virus (IAV) can be recognized by retinoic acid-inducible gene I (RIG-I) to activate the type I interferon response and induce antiviral effects.
Chenyang Yi +31 more
doaj +2 more sources
HSPD1 interacts with IRF3 to facilitate interferon-beta induction. [PDF]
PLoS ONE, 2014 The production of IFN- I (IFN-α/β) is one of the earliest and most important host-protective responses. Interferon regulatory factor 3 (IRF3) is a critical transcriptional factor in the IFN-β signaling pathway.
Lan Lin +8 more
doaj +2 more sources
Synthetic Toll-Like Receptors for Control of Innate Immunity With Far-Red Light. [PDF]
Adv Sci (Weinh)Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Leopold AV, Verkhusha VV.
europepmc +2 more sources
Viruses, 2021 The immune system defends against invading pathogens through the rapid activation of innate immune signaling pathways. Interferon regulatory factor 3 (IRF3) is a key transcription factor activated in response to virus infection and is largely responsible
Anna Glanz +6 more
doaj +1 more source
Frontiers in Microbiology, 2021 Pseudorabies virus is a typical swine alphaherpesvirus, which can cause obvious neurological disorders and reproductive failure in pigs. It is capable of evading host antiviral immune response. However, the mechanism by which many PRV proteins assist the
Jingying Xie +9 more
doaj +1 more source
Communications Biology, 2022 TOB1 is identified as an interferon regulatory factor 3 (IRF3) binding partner that operates as a negative feedback inhibitor of IFNβ in toll-like receptor and cytosolic nucleic acid receptor sensing pathways.
Zhongxia Yu +6 more
doaj +1 more source
Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3–13.4 by an intragenic polymorphic marker [PDF]
Annals of Human Genetics, 1998 We have identified a highly polymorphic intragenic marker composed of two dinucleotide repeats in an intron of the human interferon regulatory factor (IRF3) gene. This polymorphic marker has allowed us to map IRF3 to the boundary of 19q13.3–13.4 between the polymorphic markers D19S604 and D19S206 close to KLK1.
Bellingham, J. +2 more
openaire +3 more sources
mBio, 2023 Elaborate regulation of innate immunity is necessary for the host to effectively respond to invading pathogens. As an important component of antiviral immunity transcription factors, the stability and activity of interferon (IFN) regulatory factor 3 ...
Jian Wang +3 more
doaj +1 more source
Staphylococcus aureus Induces IFN-β Production via a CARMA3-Independent Mechanism
Pathogens, 2021 Type I interferon (IFN) induction is a critical component of innate immune response to viral and bacterial infection, including S. aureus, but whether it activates the signaling in macrophages and the regulation mechanisms is less well understood.
Yang Zhou +10 more
doaj +1 more source
Optineurin regulates the interferon response in a cell cycle-dependent manner. [PDF]
PLoS Pathogens, 2015 Viral invasion into a host is initially recognized by the innate immune system, mainly through activation of the intracellular cytosolic signaling pathway and coordinated activation of interferon regulatory factor 3 (IRF3) and nuclear factor kappa B (NF ...
Pierre Génin +7 more
doaj +1 more source