Results 151 to 160 of about 22,608,904 (223)
Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.The engineered DTSe‐based photosensitizer, DZTSe, emerges as an avant‐garde molecular entity, which can distribute to both the endoplasmic reticulum and mitochondria to concurrently trigger pyroptosis and activate the cGAS‐STING pathway. This dual‐action strategy effectively reprograms the tumor microenvironment, enabling potent eradication of primary ...
Cheng Zhang +7 more
wiley +2 more sources
The Significance of cGAS-STING Signaling in Response to Oncogenic Viruses. [PDF]
Cell Biochem FunctGuo L, Li L, Wang F, Liu W, Zhang Y.
europepmc +1 more source
Aging Cell, Volume 25, Issue 10, October 2026.TNF‐α upregulates Prodh2 via p53 in COPD myoblasts, driving mitochondrial ROS–induced cGAS/STING activation and myoblast dysfunction. This metabolic‐immune pathway underlies sarcopenia, positioning Prodh2 as a therapeutic target for COPD‐associated muscle wasting. ABSTRACT Sarcopenia in chronic obstructive pulmonary disease (COPD) is driven by elevated
Gang Chen +6 more
wiley +1 more source
Post-translational control of MAVS signaling: linking mitochondrial antiviral immunity to metabolic and cellular stress contexts. [PDF]
Front PhysiolMorimoto N, Okazaki T.
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Endothelial TLR4 at the Crossroads of Vascular Senescence and Targeted Senotherapeutics
Aging Cell, Volume 25, Issue 10, October 2026.While Toll‐like receptor 4 (TLR4) mediates essential innate immune responses, its stress‐induced hyperactivation drives vascular endothelial senescence. The subsequent release of the senescence‐associated secretory phenotype (SASP) accelerates tissue aging and exacerbates various age‐related diseases.
Hyo‐Jin Kim +2 more
wiley +1 more source
, 2007 Listeria monocytogenes is a prototypic bacterium for studying innate and adaptive cellular immunity as well as host defense. Using human monocyte-derived macrophages, we report that an infection with a wild-type strain, but not a listeriolysin O ...
Schweizer, Matthias +2 more
core
Ablation of Interferon Regulatory Factor 3 Promotes the Stability of Atherosclerotic Plaques. [PDF]
Hypertension, 2017 Okon I, Ding Y, Zou MH.
europepmc +1 more source
Splicing Factor Mutations in Clonal Hematopoiesis and Progression to Myeloid Neoplasms
Cancer Science, Volume 117, Issue 10, Page 2609-2618, October 2026.Splicing factor (SF)‐mutant CH is characterized by relatively late emergence and accelerated clonal expansion in older individuals. This review summarizes its clonal dynamics, disease‐associated consequences of SF mutations in myeloid neoplasms, and candidate mechanisms that may contribute to age‐dependent selection.
Yang Lyu, Yutong Zhang, Ayana Kon
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Interferon-Stimulated Gene-Mediated Defense Against Prion Infection: Noncanonical Function of Oas1a. [PDF]
VirusesHomma T, Ishibashi D.
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Journal of Fish Diseases, Volume 49, Issue 10, October 2026.ABSTRACT Cell lines are essential tools for studying animal physiology and immunopathology, reducing the use of live animals and supporting the 3Rs principle of reduction, refinement, and replacement. The Senegalese sole (Solea senegalensis), a relevant species for Spanish aquaculture diversification, lacks established in vitro models. We developed SsB‐
Yulema Valero, Alberto Cuesta
wiley +1 more source