Results 161 to 170 of about 22,608,904 (223)

Immune Evasion by Neurotropic Viruses: Molecular Strategies, Cellular Targets, and Consequences for CNS Infection. [PDF]

Int J Mol Sci
Mouzakis A, Petrakis V, Chlichlia K.
europepmc   +1 more source

Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates

Chemistry – A European Journal, Volume 32, Issue 36, 24 September 2026.
The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma, Peter A. C. Wing, Wojtek Treyde, Shyam Basak, Simeon D. Draganov, Taylah Andrews‐Clark, Eidarus Salah, Petra Lukacik, Claire Strain‐Damerell, Adán Pinto‐Fernández, Martin A. Walsh, Fernanda Duarte, Christopher J. Schofield, Lennart Brewitz   +13 more
wiley   +1 more source

Interferon regulatory factors orchestrate CD8⁺ T cell function (Review). [PDF]

Int J Mol Med
Wang FX, Yang CL, Rong SJ, Chen QJ, Yue XT, Sun F.   +5 more
europepmc   +1 more source

ATG13 promotes K63-linked polyubiquitination of MAVS via ASB1 to restrict influenza A virus replication. [PDF]

Emerg Microbes Infect
Lu Y, Chen J, Xiao H, Li J, Wang H, Liang T, Wang J, Pang X, Cheng M, Sun Y, Cui T, Pu F, Zhan J, Zhao Y, Bao H, Yang W, Jiang Y, Yang G, Wang J, Cao X, Wang C, Bai X, Zeng Y.   +22 more
europepmc   +1 more source

Expulsion of nuclear DNA to the cytoplasm after viral entry: A mechanism for activation of the cGAS pathway. [PDF]

Proc Natl Acad Sci U S A
Romero N, Oh HS, Mertens ME, Ericsson M, Stearns KN, Moscona A, Knipe DM.   +6 more
europepmc   +1 more source

TRIM56 Promotes Antiviral Responses Downstream of TLR4. [PDF]

Viruses
Tong X, Li NL, Yang D, Liu BM, Li ZA, Li K.   +5 more
europepmc   +1 more source

The Role of cGAS-STING-Driven PANoptosis in Neurodegenerative Diseases and Therapeutic Prospects. [PDF]

Cells
Hou X, Yu W.
europepmc   +1 more source

Interferon Regulatory Factor 3 in Interferon Gamma Receptor Signaling and Cancer Immunology

Every year millions of people die from cancer throughout the world, and tens of millions of people are diagnosed with cancer worldwide. When surgery is not an option, treatment options commonly rely on the host immune system for optimal treatment ...
Guinn, Zachary P.
core  

FBXO11 and FBXO32 synergistically activate innate immunity against hepatitis B virus in a NEDD8-dependent manner. [PDF]

Front Immunol
Li L, Tao S, Zhang Y, Zeng Z, Li L, Zhang J.   +5 more
europepmc   +1 more source

KMT5A-mediated methylation of IRF3 promotes tumor progression through immune suppression. [PDF]

iScience
Li P, Yu C, Xie R, Huang C, Wu Q, Liu A, She X, Li M, Rao Z, Liu L, Wang G, Hu J, Sun L.   +12 more
europepmc   +1 more source