Results 21 to 30 of about 306,829 (312)
Phleboviruses and the Type I Interferon Response
Viruses, 2016 The genus Phlebovirus of the family Bunyaviridae contains a number of emerging virus species which pose a threat to both human and animal health. Most prominent members include Rift Valley fever virus (RVFV), sandfly fever Naples virus (SFNV), sandfly ...
Jennifer Deborah Wuerth +1 more
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Type I Interferon Induction in Cutaneous DNA Damage Syndromes
Frontiers in Immunology, 2021 Type I interferons (IFNs) as part of the innate immune system have an outstanding importance as antiviral defense cytokines that stimulate innate and adaptive immune responses.
Benjamin Klein, Claudia Günther
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Differential induction of TLR3-dependent innate immune signaling by closely related parasite species. [PDF]
PLoS ONE, 2014 The closely related protozoan parasites Toxoplasma gondii and Neospora caninum display similar life cycles, subcellular ultrastructure, invasion mechanisms, metabolic pathways, and genome organization, but differ in their host range and disease ...
Daniel P Beiting +8 more
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Type I interferon, anti-interferon antibodies, and COVID-19 [PDF]
The Lancet Rheumatology, 2021 Author(s): Calabrese, Leonard H; Winthrop, Kevin; Strand, Vibeke; Yazdany, Jinoos; Walter, Jolan ...
Calabrese, Leonard H +4 more
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Type I Interferon Signaling Controls Gammaherpesvirus Latency In Vivo
Pathogens, 2022 Gammaherpesviruses, such as Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus, are important human pathogens involved in lymphoproliferative disorders and tumorigenesis.
Johannes Schwerk +14 more
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Hantavirus Regulation of Type I Interferon Responses
Advances in Virology, 2012 Hantaviruses primarily infect human endothelial cells (ECs) and cause two highly lethal human diseases. Early addition of Type I interferon (IFN) to ECs blocks hantavirus replication and thus for hantaviruses to be pathogenic they need to prevent early ...
Valery Matthys, Erich R. Mackow
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Viruses, 2012 Porcine reproductive and respiratory syndrome virus (PRRSV) is not only a poor inducer of type I interferon but also inhibits the efficient induction of type I interferon by porcine transmissible gastroenteritis virus (TGEV) and synthetic dsRNA molecules,
Xiuqing Wang, Jane Christopher-Hennings
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Type I interferon in rheumatic diseases [PDF]
Nature Reviews Rheumatology, 2018 The type I interferon pathway has been implicated in the pathogenesis of a number of rheumatic diseases, including systemic lupus erythematosus, Sjögren syndrome, myositis, systemic sclerosis, and rheumatoid arthritis. In normal immune responses, type I interferons have a critical role in the defence against viruses, yet in many rheumatic diseases ...
Theresa L Wampler, Muskardin +1 more
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Tick-Borne Flaviviruses and the Type I Interferon Response
Viruses, 2018 Flaviviruses are globally distributed pathogens causing millions of human infections every year. Flaviviruses are arthropod-borne viruses and are mainly transmitted by either ticks or mosquitoes.
Richard Lindqvist +2 more
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Fine-Tuning of Type I Interferon Response by STAT3
Frontiers in Immunology, 2019 Type I interferon (IFN-I) is induced during innate immune response and is required for initiating antiviral activity, growth inhibition, and immunomodulation. STAT1, STAT2, and STAT3 are activated in response to IFN-I stimulation.
Ming-Hsun Tsai +4 more
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