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Biology of interleukin-10 [PDF]
Cytokine & Growth Factor Reviews, 2010 Interleukin (IL)-10 is the most important cytokine with anti-inflammatory properties besides TGF-β and IL-35. It is produced by activated immune cells, in particular monocytes/macrophages and T cell subsets including Tr1, Treg, and Th1 cells. IL-10 acts through a transmembrane receptor complex, which is composed of IL-10R1 and IL-10R2, and regulates ...Robert, Sabat, Gerald, Grütz, Katarzyna, Warszawska, Stefan, Kirsch, Ellen, Witte, Kerstin, Wolk, Jens, Geginat +6 moreopenaire +2 more sourcesMapping of the interleukin‐10/interleukin‐10 receptor combining site [PDF]
Protein Science, 1998 AbstractThe discontinuous interleukin‐10(IL‐10)/interleukin‐10 receptor (IL‐10R) combining site was mapped using sets of overlapping peptides derived from both binding partners bound to continuous cellulose membranes. Low affinity binding of single regions of the discontinuous contact sites on IL‐10 and IL‐10R could be identified due to (1) high ...U, Reineke, R, Sabat, H D, Volk, J, Schneider-Mergener +3 moreopenaire +2 more sourcesPrevention of arthritis by interleukin 10-producing B cells [PDF]
, 2003 In this study we have shown that activation of arthritogenic splenocytes with antigen and agonistic anti-CD40 gives raise to a B cell population that produce high levels of interleukin (IL)-10 and low levels of interferon (IFN)-{gamma}. Transfer of these Mauri, C., Mushtaq, N., Marco Londei, Claudia Mauri, Naseem Mushtaq, Gray, D., Londei, M., David Gray +7 morecore +1 more sourceInterleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study [PDF]
, 2012 Background: Interleukin-22 (IL-22), recently identified as a crucial parameter of pathology in experimental liver damage, may determine survival in clinical end-stage liver disease.Stefan Zeuzem, Herrmann, Eva, Oliver Waidmann, Kronenberger, Bernd, Friederike Brunner, Rudloff, Ina, Bernd Kronenberger, Waidmann, Oliver, Albrecht Piiper, Pfeilschifter, Josef (Prof. Dr.), Piiper, Albrecht, Heiko Mühl, Filmann, Natalie, Ina Rudloff, Malte Bachmann, Eva Herrmann, Josef Pfeilschifter, Lisa Kapper, Bachmann, Malte, Brunner, Friederike, Kapper, Lisa, Mühl, Heiko, Natalie Filmann, Zeuzem, Stefan, Kronenberger Bernd, Brunner Friederike, Filmann Natalie, Kapper Lisa, Herrmann Eva, Zeuzem Stefan, Mühl Heiko, Rudloff Ina, Piiper Albrecht, Waidmann Oliver, Bachmann Malte, Pfeilschifter Josef +35 morecore +2 more sourcesCirculating interleukin-10 and risk of cardiovascular events: a prospective study in the elderly at risk [PDF]
, 2011 <p><b>Objective:</b> The goal of this study was to examine the association of the antiinflammatory interleukin-10 (IL-10) with risk of cardiovascular disease (CVD).</p>
<p><b>Methods and Results:</b> In the ...Jukema, J.W., Trompet, S., Sattar, N., David J. Stott, Jukema, J. Wouter, Heather M. Murray, Ian Ford, Ford, I., Welsh, Paul, Anton J.M. de Craen, McInnes, Iain B., Trompet, Stella, Paul Welsh, J. Wouter Jukema, Westendorp, Rudi G.J., McInnes, I.B., Welsh, P., Westendorp, R.G.J., Packard, C.J., Murray, H.M., Craen, A.J.M. de, de Craen, Anton J.M., Rudi G.J. Westendorp, Sattar, Naveed, Stella Trompet, Stott, David J., Naveed Sattar, Ford, Ian, Chris J. Packard, Murray, Heather M., PROSPER Study Grp, Packard, Chris J., Iain B. McInnes, Stott, D.J. +33 morecore +1 more sourceIn vitro generation of interleukin-10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper 1 (Th1)- and Th2-inducing cytokines [PDF]
, 2002 We show that a combination of the immunosuppressive drugs, vitamin D3 and Dexamethasone, induced human and mouse naive CD4(+) T cells to differentiate in vitro into regulatory T cells.Hawrylowicz, C.M., Robert L. Coffman, André Boonstra, Richards, David F, Richards, D.F., Catherine M. Hawrylowicz, Savelkoul, H.F.J., Savelkoul, HFJ (Huub), Crain, Chad, Anne O'Garra, O' Garra, A, Coffman, R.L., O'Garra, Anne, Cua, D.J., Chad Crain, Cua, DJ, Huub F. Savelkoul, Coffman, RL, Waal-Malefyt, R., de, Cua, Daniel J, Savelkoul, Huub F, Barrat, Franck J, de Waal-Malefyt, René, de Waal-Malefyt, R, Hawrylowicz, Catherine M; id_orcid, Crain, C., Barrat, FJ, Barrat, F.J., Crain, C, Coffman, Robert L, Boonstra, P.A., Daniel J. Cua, Hawrylowicz, CM, Franck J. Barrat, David F. Richards, O'Garra, A., René de Waal-Malefyt, Richards, DF, Boonstra, Andre +38 morecore +1 more sourceInterleukin-10 in the intestine [PDF]
Gut, 1997 See article on page215 Cytokines are small glycoprotein mediators involved in communication between cells. Immunological responses are, to a high degree, regulated and directed by specific cytokines. The simultaneous action of different cytokines, as well as their sequential interaction with target cells, seems to be of pivotal importance for an ...openaire +2 more sourcesSex-dependent susceptibility to Listeria monocytogenes infection is mediated by differential interleukin-10 production [PDF]
, 2005 It is well documented that sex-dependent factors affect susceptibility to infection, with most mouse models demonstrating higher resistance in females.Bastian Pasche, Helmut Fuchs, Andreas Lengeling, Hrabě de Angelis, M., Franz, T.J., Busch, D.H., Tobias J. Franz, Pasche, B., Busch, Dirk H, Busch, Dirk H., Kalaydjiev, S., Kremmer, E., Valérie Gailus-Durner, Martin Hrabé de Angelis, Kremmer, Elisabeth, Franz, Tobias J., De Angelis, Martin Hrabé, Pasche, Bastian, Dirk H. Busch, Lengeling, A., Fuchs, H., Fuchs, Helmut, Kalaydjiev, Svetoslav, Gailus-Durner, Valérie, Hrabé de Angelis, Martin, Lengeling, Andreas, Svetoslav Kalaydjiev, Gailus-Durner, V., Franz, Tobias J, Elisabeth Kremmer, Pasche, B;Kalaydjiev, S;Franz, TJ;Kremmer, E;Gailus-Durner, V;Fuchs, H;Hrabé de Angelis, M;Lengeling, A;Busch, DH, Pasche, B. ; Kalaydjiev, S. ; Franz, T.J. ; Kremmer, E. ; Gailus-Durner, V. ; Fuchs, H. ; Hrabé de Angelis, M. ; Lengeling, A. ; Busch, D.H. +31 morecore +1 more sourceInterleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies [PDF]
, 2012 BACKGROUND: Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades.Thomas, GN, Willeit, P, Trip, MD, Willeit, J, Nelson, Christopher P, Samani, NJ, Danesh, J, Psaty, Bruce M., Assimes, Themistocles L., Stringham, Heather M, Kastelein, JJP, Adamovic, Svetlana, Franks, Paul W., Trip, Mieke D, Harris, Tamara B, Meade, TW, Thomas, Graham; id_orcid, Tivesten, A, de Bakker, PIW, Tybjærg-Hansen, Anne, Boehnke, M, de Bakker, Paul IW, Wilson, Anthony G, Trip, Mieke D., Witteman, Jacqueline C. M., Freitag, DF, Sarwar, Nadeem, Gao, P, Gallacher, John Edward, Ljunggren, Osten, Qi, Lu, Hall, Alistair S., Samani, Nilesh J., Karlsson, Magnus, Hofman, Bert, Goodall, AH, Watkins, H, Arbor, Ann, Davey Smith, George, Chambers, John C, Shaffer, Jonathan A, Butterworth, Adam S., Tracy, Russell P, O'Donnell, CJ, Gorman, Donal N., Psaty, Bruce M, Panagiotakos, DB, Wilde, Arthur AM, Best, LG, Di Angelantonio, Emanuele, Sundstrom, J, Butterworth, AS, Emerging Risk Factors Collaboration (Döring, A. ; Meisinger, C.), Cambien, Francois, Gregson, J, Gorman, Donal N, Best, Lyle G., Manson, JE, Rimm, Eric B, Wennberg, P, de Bakker, Paul I. W., Melzer, D, Qi, L, Gillum, Richard F, Kleber, ME, Gallacher, John, Kastelein, John JP, Chasman, DI, Cambien, F, Ridker, Paul M, Salomaa, Veikko, Hall, AS, Benjamin, Emelia J., Chasman, Daniel I, Salonen, JT, Kaptoge, S, Salonen, Jukka T., O'Donnell, Christopher J., Ingelsson, Erik, Benjamin, Emelia J, Freitag, Daniel F, Rader, Daniel J., Tracy, Russell P., Salonen, Jukka T, Saleheen, D, ?, ?, Salomaa, V, Clarke, Robert, Kleber, Marcus E., Chambers, JC, Witteman, Jacqueline C M, Braund, Peter S., Manson, JoAnn E., Boehnke, Michael, Ouwehand, Willem H, Rendon, A, Wilson, Anthony G., Harari, Olivier, Hopewell, Jemma C., Wilson, AG, Tracy, RP, Karlsson, M, Cantin, B, Reilly, Muredach P., Ohlsson, C, Melzer, David, IL6R Genetics Consortium Emerging Risk Factors Collaboration, Meade, Tom W, Benjamin, EJ, Stringham, Heather M., Freitag, Daniel F., Cantin, Bernard, Gregson, John, Chasman, Daniel I., Butterworth, Adam S, Reich, David, Braund, PS, Schunkert, H, Di Angelantonio, E, Ouwehand, WH, Harris, Tamara B., Thomas, G. Neil, Allin, Kristine H., Nelson, CP, Allin, Kristine Højgaard, Best, Lyle G, de Faire, Ulf, Davey-Smith, George, Kooner, Jaspal S, Gudnason, Vilmundur, Rimm, Eric B., Shaffer, Jonathan A., Sundstrom, Johan, Jansson, JO, Erdmann, Jeanette, Steri, M, Kauhanen, J, Holm, H, Samani, Nilesh J, Nordestgaard, BG, Mellstrom, Dan, Rader, Daniel J, Kaptoge, Stephen, Goodall, Alison H., Meade, Tom W., Clarke, R, Shaffer, JA, Ben-Shlomo, Yoav, Wilson, James F, Witteman, JCM, Ridker, PM, Davey-Smith, G, Tivesten, Asa, Koenig, W, Franks, Paul W.,, O'Donnell, Christopher J, Allin, Kristine H, van der Schoot, CE, Reilly, MP, Asselbergs, FW, Nelson, Christopher P., Hung, J, Danesh, John, Witteman, Jacqueline CM, Gudnason, V, Adamovic, S, Holm, Hilma, Kleber, Marcus E, Cushman, M, Ljunggren, Östen,, Erdmann, J, Koenig, Wolfgang, Rimm, EB, Hung, Joseph, Asselbergs, Folkert W., van der Schoot, C. Ellen, Wassertheil-Smoller, S, Kooner, Jaspal S., Panagiotakos, Demosthenes B, Franks, Paul, Willeit, Peter, Nordestgaard, Børge G, Kooner, JS, Chambers, John C., Tybjaerg-Hansen, Anne, Nordestgaard, Borge G., Tybjaerg-Hansen, A, Kauhanen, Jussi, Wilde, Arthur A. M., Gillum, RF, Watkins, Hugh, Mellstrom, D, Thomas, G Neil, Sarwar, N, de Faire, U, Wilde, AAM, Psaty, BM, Ben-Shlomo, Y, Panagiotakos, Demosthenes B., Ljunggren, O, Harris, TB, Sundström, Johan,, Reilly, Muredach P, Wilde, Arthur A M, Asselbergs, Folkert W, Woodward, Mark, Stringham, HM, Harari, O, Saleheen, Danish, Schunkert, Heribert, Hall, Alistair S, Cushman, Mary, Gorman, DN, Gillum, Richard F., Hopewell, Jemma C, Wilson, JF, IL6R Genetics Consortium, Rader, DJ, Wilson, James F., Kastelein, John J. P., Woodward, M, Hopewell, JC, Hofman, Albert, Rendon, Augusto, Wennberg, Patrik, Jansson, John-Olov, Wilhelmsen, L, Reich, D, Manson, JoAnn E, Onat, A, Amouyel, Philippe, Hamsten, A, Ingelsson, E, Franks, Paul W, Willeit, Johann, Onat, Altan, Wilhelmsen, Lars, Assimes, Themistocles L, Gallacher, J, Wassertheil-Smoller, Sylvia, van der Schoot, C Ellen, Assimes, TL, Goodall, Alison H, Franks, PW, Amouyel, P, Steri, Maristella, Ohlsson, Claes, Braund, Peter S, Allin, KH, Hamsten, Anders, Ridker, Paul M., Ouwehand, Willem H., Gao, Pei, Uitterlinden AG, Stark K, Asselbergs FW, Gregson J, Baumert J, Böhm BO, Kleber ME, Butterworth AS, de Jong JS, Yarnell JW, Danesh J. Collaborators Assimes TL, Wennberg P, Rimm EB, Preuss M, Qi L, Ripatti S, Stefanadis C, Smith AV, Ben Shlomo Y, Rasheed A, Ridker PM, Goodall AH, Karlsson, Magnus,, Kuusisto J, Tikkanen E, Rose LM, Perola M, Dupuis J, Armitage J, Mukamal KJ, Wilson JF, Nordestgaard BG, Hu FB, Jula A, Cheng KK, Reich D, Thorsteinsdóttir U, Thompson PL, Quertermous T, Nieminen MS, Illig T, Lind L, Gallacher J, Tivesten Å, Basu S, Mellström D, Stringham HM, Winkelmann BR, Silveira A, Tivesten, Åsa,, O'Donnell CJ, Whincup PH, Arveiler D, Morris RW, Guralnik JM, Sinisalo J, Maiwald S, Scharnagl H, Jansson JH, van der Schouw YT, Jansson JO, Tuomainen TP, Chasman DI, Freitag DF, Hengstenberg C, Tracy RP, Peden JF, Dehghan A, Fontes JD, Lam TH, Gigante B, Sivapalaratnam S, Hall AS, Harris TB, Lund University., Laakso M, Wilde AA, Nahrstaedt J, Deloukas P, Dagenais GR, Sarwar N, Qu L, Hofman A, Benjamin EJ, Loley C, Kastelein JJ, Rumley A, Heckbert SR, Koenig IR, Beilby JP, Clarke R, Bezzina CR, Amouyel P, Howard BV, Kaptoge S, de Bakker PI, Willenborg C, Shungin D, Schunkert H, Wassertheil Smoller S, Gillum RF, Barroso I, Mellström, Dan,, Gao P, Di Angelantonio E, Tuomilehto J, Cantin B, Shaffer JA, Jansson, John-Olov,, Ingelsson E, Männistö S, Knowles JW, Wilhelmsen L, Singleton AB, Koenig W, Chambers JC, Das D, Davidson KW, Psaty BM, Willeit J, Willeit P, Hlatky MA, Hankinson SE, Schreiber S, Wiggins KL, Panagiotakos DB, Dekker LR, Salonen JT, Manson JE, Thomas GN, Watkins H, Lokki ML, Pai J, Ljunggren Ö, McQuillan BM, Buring J., Adamovic, Svetlana,, Go AS, Gorman DN, Boehnke M, Bis JC, Witteman JC, Adamovic S, Sheikh N, Havulinna AS, Thorleifsson G, Reilly MP, Folsom AR, Sanna S, Fraser R, Meisinger C, Karlsson MK, Kauhanen J, Li M, van Duijn CM, Cambien F, Samani NJ, Davey Smith G, Assimes TL, de Faire U, Meade TW, van der Schoot CE, Verschuren WM, Ohlsson, Claes,, Motazacker M, Allin KH, Sabater Lleal M, Smith NL, Danesh J, Jackson A, Kurl S, Tanck M, Shea SJ, Yin X, Kooner JS, Collins R, Zhang W, Steri M, Thorand B, Saleheen D, CUCCA, Francesco, Gudnason V, Harari O, Melzer D, Onat A, Best LG, Tybjærg Hansen A, Nelson CP, Onland Moret NC, Franks PW, Rosengren A, Karlsson M, Erdmann J, Basart H, Wannamethee SG, Salomaa V, Ouwehand WH, Trip MD, Woodward M, Rendon A, Parish S, Balmforth AJ, Braund PS, Stefansson K, Abecasis GR, Ohlsson C, Sundström J, Hveem K, Hólm H, Ferrucci L, Syvänen AC, Hallmans G, Hopewell JC, Lowe G, Pitsavos C, Kiechl S, Farrall M, Thorgeirsson G, Hamsten A, Rader DJ, Boer JM, Franks, Paul,, Jiang CC, Chrysohoou C, Hung J, Bandinelli S, Schlessinger D, März W, Uda M, Cushman M, Wilson AG, Thompson JR, Qasim A, Sarwar, N;Butterworth, AS;Freitag, DF;Gregson, J;Willeit, P;Gorman, DN;Gao, P;Saleheen, D;Rendon, A;Nelson, CP;Braund, PS;Hall, AS;Chasman, DI;Tybjærg-Hansen, A;Chambers, JC;Benjamin, EJ;Franks, PW;Clarke, R;Wilde, AA;Trip, MD;Steri, M;Witteman, JC;Qi, L;van der Schoot, CE;de Faire, U;Erdmann, J;Stringham, HM;Koenig, W;Rader, DJ;Melzer, D;Reich, D;Psaty, BM;Kleber, ME;Panagiotakos, DB;Willeit, J;Wennberg, P;Woodward, M;Adamovic, S;Rimm, EB;Meade, TW;Gillum, RF;Shaffer, JA;Hofman, A;Onat, A;Sundström, J;Wassertheil-Smoller, S;Mellström, D;Gallacher, J;Cushman, M;Tracy, RP;Kauhanen, J;Karlsson, M;Salonen, JT;Wilhelmsen, L;Amouyel, P;Cantin, B;Best, LG;Ben-Shlomo, Y;Manson, JE;Davey-Smith, G;de Bakker, PI;O'Donnell, CJ;Wilson, JF;Wilson, AG;Assimes, TL;Jansson, JO;Ohlsson, C;Tivesten, Å;Ljunggren, Ö;Reilly, MP;Hamsten, A;Ingelsson, E;Cambien, F;Hung, J;Thomas, GN;Boehnke, M;Schunkert, H;Asselbergs, FW;Kastelein, JJ;Gudnason, V;Salomaa, V;Harris, TB;Kooner, JS;Allin, KH;Nordestgaard, BG;Hopewell, JC;Goodall, AH;R, Campbell H, Wild S, Kooner AS +489 morecore +1 more source
