Results 11 to 20 of about 626,390 (233)

B cell-intrinsic interleukin 17 receptor A signaling supports the establishment of chronic murine gammaherpesvirus 68 infection [PDF]

Journal of Virology
The human-specific gammaherpesviruses Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus infect >95% of all adults, establish lifelong infections, and are associated with multiple different cancers, including B-cell lymphomas.
Sheikh Tahir Majeed, Nicholas P. Huss, Samantha M. Bradford, Christopher N. Jondle   +3 more
doaj   +2 more sources

Interleukin 17 Receptor Gene Polymorphism in Periimplantitis and Chronic Periodontitis

Acta Medica Iranica, 2013
Gene polymorphism of cytokines influencing their function has been known as a contributing factor in the pathogenesis of inflammatory diseases of the tooth and implant supporting tissues. The aim of this study was to investigate the association of IL-17R
Mahdi Kadkhodazadeh, Ahmad Reza Ebadian, Reza Amid, Navid Youssefi, Amir Reza Mehdizadeh   +4 more
doaj   +4 more sources

The deubiquitinase A20 mediates feedback inhibition of interleukin-17 receptor signaling. [PDF]

Sci Signal, 2013
Inhibition of an inflammatory cytokine signaling pathway by A20 at the receptor may play a role in preventing autoimmunity.
Garg AV, Ahmed M, Vallejo AN, Ma A, Gaffen SL.   +4 more
europepmc   +4 more sources

Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis. [PDF]

Immunity, 2014
Interleukin-17A (IL-17A) is a pro-inflammatory cytokine linked to rapid malignant progression of colorectal cancer (CRC) and therapy resistance. IL-17A exerts its pro-tumorigenic activity through its type A receptor (IL-17RA). However, IL-17RA is expressed in many cell types, including hematopoietic, fibroblastoid, and epithelial cells, in the tumor ...
Wang K, Kim MK, Di Caro G, Wong J, Shalapour S, Wan J, Zhang W, Zhong Z, Sanchez-Lopez E, Wu LW, Taniguchi K, Feng Y, Fearon E, Grivennikov SI, Karin M.   +14 more
europepmc   +5 more sources

Levels of IL-23/IL-17 Axis in Plasma and Gingival Tissue of Periodontitis Patients According to the New Classification

Applied Sciences, 2022
Background: Periodontitis (P) is a chronic inflammatory disease characterized by the destruction of periodontium support tissue generated by different immuno-inflammatory mechanisms, including the RANK/RANKL/OPG and the IL-23/IL-17 axis.
Ruth Rodríguez-Montaño, Alondra del Carmen Ruiz-Gutiérrez, Vianeth María del Carmen Martínez-Rodríguez, Juan Ramón Gómez-Sandoval, Juan Manuel Guzmán-Flores, Julieta Sarai Becerra-Ruiz, Ana Lourdes Zamora-Perez, Celia Guerrero-Velázquez   +7 more
doaj   +1 more source

SELEX-discovered aptamer that inhibits cellular interleukin-17/interleukin-17 receptor interaction and antagonizes interleukin-17 signaling

Bioscience, Biotechnology, and Biochemistry, 2023
ABSTRACT This research is based on a Systematic Evolution of Ligands by EXponential enrichment, also referred to as in vitro selection against the extracellular domain of human interleukin-17 receptor A (IL-17RA). Pull-down assay via quantitative polymerase chain reaction and chemiluminescence detection showed that the cloned RNA with ...
Arifur Rahman Munshi, Tong Wang, Yukio Takamori, Takehiro Ando, Takumi Yokoyama, Daisuke Fuji, Zhehao Xu, Santhana Vedi, Mizuki Yamamoto, Keita Tsukamoto, Takashi Kawakami   +10 more
openaire   +2 more sources

Study on the Mechanism of Budesonide in the Treatment of IgA Nephropathy Based on Network Pharmacology [PDF]

Zhongguo quanke yixue, 2023
Background IgA nephropathy (IgAN) is the most common primary glomerulonephritis in China and worldwide, approximately 25%-30% of patients will progress to end-stage renal disease within 20 years after diagnosis.
ZHANG Kang, ZHAO Tingting, ZHANG Bo, GAO Mengqi, LI Yuxi, WANG Shaopeng, ZHAO Wenjing
doaj   +1 more source

Genetic association between interleukin-17 and susceptibility to rheumatoid arthritis

BMC Medical Genomics, 2023
Background The pathogenesis of rheumatoid arthritis (RA) is an immune imbalance, in which various inflammatory immune cells and pro-inflammatory factors are involved.
Rong Zhao, Yi-wen Zhang, Jia-yuan Yao, Jun Qiao, Shan Song, Sheng-xiao Zhang, Cai-hong Wang, Xiao-feng Li   +7 more
doaj   +1 more source

Effect of interleukin (IL)-35 on IL-17 expression and production by human CD4+ T cells [PDF]

PeerJ, 2017
Background Interleukin (IL)-17 produced by mainly T helper 17 (Th17) cells may play an important destructive role in chronic periodontitis (CP). Thus, anti-inflammatory cytokines, such as IL-35, might have a beneficial effect in periodontitis by ...
Kosuke Okada, Takeki Fujimura, Takeshi Kikuchi, Makoto Aino, Yosuke Kamiya, Ario Izawa, Yuki Iwamura, Hisashi Goto, Iichiro Okabe, Eriko Miyake, Yoshiaki Hasegawa, Makio Mogi, Akio Mitani   +12 more
doaj   +2 more sources

Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis

Military Medical Research, 2022
Idiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease with no established treatment and is characterized by progressive scarring of the lung tissue and an irreversible decline in lung function.
Yun-Juan Nie, Shuo-Hua Wu, Ying-Hua Xuan, Gen Yan   +3 more
doaj   +1 more source