Virus-Like Particle-Mediated Vaccination against Interleukin-13 May Harbour General Anti-Allergic Potential beyond Atopic Dermatitis [PDF]
, 2020 Virus-like particle (VLP)-based anti-infective prophylactic vaccination has been established in clinical use. Although validated in proof-of-concept clinical trials in humans, no VLP-based therapeutic vaccination against self-proteins to modulate chronic
Foerster, John, Molęda, Aleksandra
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Blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in patients with symptoms suggesting reactive hypoglycemia [PDF]
Brazilian Journal of Medical and Biological Research, 2016 We evaluated the impact of postprandial glycemia on blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in non-diabetic patients with symptoms suggesting reactive hypoglycemia.
W. Eik Filho +6 more
doaj +3 more sources
MicroRNAs and other mechanisms regulate interleukin-17 cytokines and receptors [PDF]
Frontiers in Bioscience, 2012 Interleukin-17 cytokines are a family of pro-inflammatory cytokines. Our current studies found: i) IL-17 cytokines are not ubiquitously expressed, but several receptors and TRAF3IP2 are ubiquitously expressed in tissues with a few exceptions; ii) heart and vascular tissue are in the second tier of readiness to respond to IL-17 cytokine stimulation; iii)
Jietang, Mai +9 more
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Structural basis of receptor sharing by interleukin 17 cytokines [PDF]
Nature Immunology, 2009 Interleukin 17 (IL-17)-producing helper T cells (T(H)-17 cells), together with their effector cytokines, including members of the IL-17 family, are emerging as key mediators of chronic inflammatory and autoimmune disorders. Here we present the crystal structure of a complex of IL-17 receptor A (IL-17RA) bound to IL-17F in a 1:2 stoichiometry.
Ely, Lauren K. +2 more
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Targeting interleukin-17 receptors
Oncotarget, 2015 During the last decade, increasing evidence suggests a strong association between chronic inflammation and cancer development among different types of cancer. The dysregulation of pro-inflammatory cytokines or their receptors is a common feature observed in many cancers [1]. Cancer cells take advantage of cytokine or cytokine receptor overexpression to
Wen-Hwa, Lee +2 more
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Pro-inflammatory signaling by IL-10 and IL-22: bad habit stirred up by interferons? [PDF]
, 2013 Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of ...
Mühl, Heiko
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The interleukin-17 receptor B subunit is essential for the Th2 response to Helicobacter pylori, but not for control of bacterial burden. [PDF]
PLoS ONE, 2013 Helicobacter pylori infection leads to an inflammatory response in 100% of infected individuals. The inflammatory cells which are recruited to the gastric mucosa during infection produce several pro- and anti-inflammatory cytokines including several ...
Dennis J Horvath +4 more
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Progress in spondylarthritis immunopathogenesis of spondyloarthritis: which cells drive disease? [PDF]
, 2009 Spondyloarthritides, or SpA, form a cluster of chronic inflammatory diseases with the axial skeleton as the most typical disease localisation, although extra-articular manifestations such as intestinal inflammation may frequently occur during the course ...
Melis, Lode, Elewaut, Dirk
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Clinical significance of Interleukin 17 receptor E in diabetic nephropathy
International Immunopharmacology, 2023 Diabetic nephropathy (DN) is a leading cause of end-stage renal disease. Since there are limited therapeutic options available for the prevention of DN progression, it is imperative to explore novel differentially expressed genes and therapeutic targets for DN.In this study, mice kidney tissue were subjected to transcriptome sequencing and the results ...
Jingjing Wang +5 more
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Frontiers in Cell and Developmental Biology, 2020 ObjectivesMyeloid dendritic cells (DCs) in patients with allergic rhinitis (AR) express higher levels of IL-17RB, ST2, and TSLPR. However, their functional roles in DCs are much less clear.
Rui Zheng +6 more
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