Results 221 to 230 of about 582,539 (259)

Interleukin 18 and Periodontal Disease

Journal of Dental Research, 2007
Cytokines are of major importance in periodontal disease progression. It is generally agreed that control of the Th1/Th2 balance is central to the immunoregulation of periodontal disease. There is increasing evidence in humans that the stable periodontal lesion is mediated by Th1 cells, while the progressive lesion sees a shift toward Th2 cells ...
Orozco, A., Gemmell, E., Bickel, M., Seymour, G. J.   +3 more
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Interleukin-18

Methods, 1999
Interleukin (IL)-18 is a newly discovered cytokine, structurally similar to IL-1, with profound effects on T-cell activation. This short review summarizes the present knowledge on IL-18, to give an insight into the future perspectives for its possible use as vaccine adjuvant.
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Interleukin-18 in Hemophagocytic Lymphohistiocytosis

Leukemia & Lymphoma, 2001
Hemophagocytic lymphohistiocytosis (HLH) is characterized by dysregulated hyperactivation of macrophages and T helper 1 (Th1) cells accompanied by excessive secretion of inflammatory cytokines. Although TNF-alpha and IFN-gamma are known to be important factors for the development of the disease, the mechanism of their overproduction has not been ...
H, Takada, A, Nomura, S, Ohga, T, Hara
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Interleukin-18 in cancer immunology and immunotherapy

Expert Opinion on Therapeutic Targets, 2023
Interleukin-18 (IL-18) is a myeloid leukocyte inflammatory mediator whose main known function is to elicit IFNγ secretion from T and NK cells.This function offers potential in cancer immunotherapy but as a single treatment, preclinical and clinical antitumor activities are modest.
Assunta, Cirella, Irene, Olivera, Carlos, Luri-Rey, Elixabet, Bolaños, Pedro, Berraondo, Ignacio, Melero   +5 more
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Interleukin-18 and Crohn’s Disease

Digestion, 2001
The etiology and pathogenesis of inflammatory bowel disease remains an area under intense investigation. Crohn’s disease (CD) is characterized by a marked accumulation of activated Th1 type CD4+ T cells and macrophages in inflamed intestinal mucosa. IL-18 is a recently described cytokine that mainly exists in activated macrophages and shares biological
T, Kanai, M, Watanabe, A, Okazawa, T, Sato, T, Hibi   +4 more
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Association of interleukin-18 and asthma

Inflammation, 2016
Cytokine-mediated immunity plays a dominant role in the pathogenesis of various immune diseases, including asthma. The recent identification of the family interleukin (IL)-1-related cytokine IL-18 now contributes to our understanding of the fine-tuning of cellular immunity.
Ming-Hui, Xu, Feng-Lai, Yuan, Shu-Jing, Wang, Hui-Ying, Xu, Cheng-Wan, Li, Xiao, Tong   +5 more
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Interleukin 18 and interleukin 18 binding protein in patients with idiopathic thrombocytopenic purpura

British Journal of Haematology, 2009
SummaryTo evaluate the balance of interleukin IL18 and its endogenous antagonist IL18 binding protein (IL18BP) in patients with idiopathic thrombocytopenic purpura (ITP), plasma IL18, IL18BP, interferon gamma (IFNG) and IL4 levels, as well as platelet counts were measured in patients with active ITP (n = 23), ITP in remission (n = 21) and in healthy ...
Ning-Ning, Shan, Xiao-Juan, Zhu, Jun, Peng, Ping, Qin, Xue-Wei, Zhuang, Hong-Chun, Wang, Ming, Hou   +6 more
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Interleukin 18: Friend or foe in cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2013
In the last few years, the field of tumor immunology has significantly expanded and its boundaries, never particularly clear, have become less distinct. Although the immune system plays an important role in controlling tumor growth, it has also become clear that tumor growth can be promoted by inflammatory immune responses.
Palma G, Barbieri A, Bimonte S, Palla M, Zappavigna S, CARAGLIA, Michele, Ascierto PA, Ciliberto G, Arra C.   +8 more
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Analysis of interleukin-18 promoter polymorphisms and changes in interleukin-18 serum levels underscores the involvement of interleukin-18 in recurrent spontaneous miscarriage

Fertility and Sterility, 2011
To evaluate the association of interleukin-18 (IL-18) promoter single-nucleotide polymorphisms rs1946519 (-656C/A), rs187238 (-137G/C), rs360718 (-119A/C), and rs360717 (-105G/A) and changes in IL-18 serum levels with recurrent spontaneous miscarriage (RSM).Case-control study.Outpatient obstetrics and gynecology clinics.Women with confirmed RSM (n ...
Ghada M, Al-Khateeb, Mai S, Sater, Ramzi R, Finan, Fekria E, Mustafa, Amna S, Al-Busaidi, Manar A, Al-Sulaiti, Wassim Y, Almawi   +6 more
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Adipose Tissue Interleukin‐18 mRNA and Plasma Interleukin‐18: Effect of Obesity and Exercise

Obesity, 2007
AbstractObjectives: Obesity and a physically inactive lifestyle are associated with increased risk of developing insulin resistance. The hypothesis that obesity is associated with increased adipose tissue (AT) interleukin (IL)‐18 mRNA expression and that AT IL‐18 mRNA expression is related to insulin resistance was tested.
Leick, Lotte, Lindegaard, Birgitte, Stensvold, Dorthe, Plomgaard, Peter, Saltin, Bengt, Pilegaard, Henriette   +5 more
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