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The Role of Interleukin-18 in Renal Injury
Journal of Surgical Research, 2008Interleukin (IL)-18 is a relatively new pro-inflammatory cytokine, formerly known as interferon-gamma-inducing factor, which induces interferon-gamma production in T cells and natural killer cells. It is synthesized as a biologically inactive precursor, which requires cleavage into an active molecule by an intracellular cysteine protease similar to IL ...
Jeffrey A, Leslie, Kirstan K, Meldrum
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Interleukin-18 and the treatment of rheumatoid arthritis
Rheumatic Disease Clinics of North America, 2004Interleukin (IL)-18 is a new member of the IL-1 family of proinflammatory cytokines. Based on preclinical studies in animals, IL-18 likely plays a role in rheumatoid arthritis, and strategies to block IL-18 activity are underway in clinical trials. In one of these trials,a naturally occurring IL-18 binding protein (IL-18 BP) binds IL-18 with a high ...
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Interleukins in Cancer: From Biology to Therapy
Nature Reviews Cancer, 2021Peter Libby +2 more
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Cellular Sources and Immune Functions of Interleukin-9
Nature Reviews Immunology, 2010Randolph Noelle
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Treating Inflammation by Blocking Interleukin-1 in a Broad Spectrum of Diseases
Nature Reviews Drug Discovery, 2012Jos WM van der Meer +2 more
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Interleukin-21: A Double-Edged Sword With Therapeutic Potential
Nature Reviews Drug Discovery, 2014Warren J Leonard, Rosanne Spolski
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