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Interleukin-18: recent advances
Current Opinion in Hematology, 2004Interleukin-18 (IL-18) has potent immunomodulatory effects. It is the only cytokine with a unique capacity to induce T helper 1 or T helper 2 polarization, depending on the immunologic context. Serum levels of IL-18 are increased in many human diseases and it has been implicated in the pathogenesis of several immune-mediated processes.
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The Role of Interleukin-18 in Renal Injury
Journal of Surgical Research, 2008Interleukin (IL)-18 is a relatively new pro-inflammatory cytokine, formerly known as interferon-gamma-inducing factor, which induces interferon-gamma production in T cells and natural killer cells. It is synthesized as a biologically inactive precursor, which requires cleavage into an active molecule by an intracellular cysteine protease similar to IL ...
Jeffrey A, Leslie, Kirstan K, Meldrum
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Interleukin-18 and the treatment of rheumatoid arthritis
Rheumatic Disease Clinics of North America, 2004Interleukin (IL)-18 is a new member of the IL-1 family of proinflammatory cytokines. Based on preclinical studies in animals, IL-18 likely plays a role in rheumatoid arthritis, and strategies to block IL-18 activity are underway in clinical trials. In one of these trials,a naturally occurring IL-18 binding protein (IL-18 BP) binds IL-18 with a high ...
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Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in Cardiovascular Disease
Circulation Research, 2021exaly
Biology and therapeutic potential of interleukin-10
Journal of Experimental Medicine, 2020Anne O'Garra +2 more
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Interleukin-22: Immunobiology and Pathology
Annual Review of Immunology, 2015Jarrod Dudakov, Alan Hanash
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Signaling and Function of Interleukin-2 in T Lymphocytes
Annual Review of Immunology, 2018Sarah Ross, Doreen Cantrell
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