Results 191 to 200 of about 358,202 (249)

Innovative Insights into Interleukin-Mediated Macrophage Polarization: Metabolic Reprogramming and Inflammatory Pathway Crosstalk in Chronic Kidney Disease and Therapeutic Implications-A Narrative Review. [PDF]

Int J Gen Med
Jiang Z, Zhang X, Jin L, Han M, Zhang Y, Jiang Y, Zhang J, Jin L.   +7 more
europepmc   +1 more source

PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy

Advanced Science, EarlyView.
This study shows that a PARP inhibitor combined with anlotinib, administered as bridging therapy, preconditions the tumor microenvironment to enhance the infiltration and antitumor activity of subsequently infused CAR‐T cells across preclinical ovarian cancer models, supporting bridging therapy as a promising strategy to address limited CAR‐T cell ...
Huayi Li, Minghua Xiang, Qiuyang Xu, Jiahao Liu, Xiaofei Jiao, Wei Mu, Xiaoying Lv, Kangjia Tao, Yu Xu, Dongchen Zhou, Wenjian Gong, Danmei Yan, Yixin Hu, Sen Xu, Bingbing Zhao, Jundong Li, Yongkang Gai, Guang Hu, Li Zhu, Qinglei Gao, Yong Fang   +20 more
wiley   +1 more source

Magneto‐NIR‐II‐Programmed Cascade Nanozymes Unlocking Blood–Brain Barrier Translocation and Autophagic Resistance in Glioblastoma

Advanced Science, EarlyView.
Magneto‐NIR‐II‐programmed NFSH nanozymes integrate magnetic blood–brain barrier (BBB) translocation, CD44 targeting, multimodal imaging, and cascade catalytic therapy for glioblastoma. Alternating magnetic fields and NIR‐II irradiation amplify ferroptosis, release H2S, suppress autophagic and mitophagic repair, and reshape the immune microenvironment ...
Ruocan Liu, Yundi Wu, Shuai Zhang, Hongjuan Zhao, Jiping Zheng, Shiyang Shao, Jianqiang Chen, Xilong Wu   +7 more
wiley   +1 more source

Danger or Salvation? The Role of DAMPs in Cancer Therapy. [PDF]

Cancers (Basel)
Vedunova AA, Guryev EL, Gudkov SV, Mishchenko TA, Vedunova MV.   +4 more
europepmc   +1 more source

MiR‐146a‐5p Suppresses M1 Polarization of Tumor‐Associated Macrophages via IRAK1/NF‐κB Signaling in Colorectal Polyps

Annals of Gastroenterological Surgery, EarlyView.
MiR‐146a‐5p is downregulated in colorectal polyps, leading to IRAK1 upregulation and NF‐κB activation, which promotes M1 macrophage polarization and inflammation. Overexpression of miR‐146a‐5p suppresses IRAK1/NF‐κB signaling, reduces M1 polarization, and alleviates inflammatory responses.
Peng Song, Lianhui Wu, Huabin Qiu, Lei Luo, Jianzhao Qiu, Shuping Xiao, Jincai He   +6 more
wiley   +1 more source

Celastrol Ameliorates Renal Injury in Spontaneously Hypertensive Rats by Activating the Nrf2/Ho-1 Signaling Pathway to Alleviate Oxidative Stress. [PDF]

Int J Mol Sci
Deng Y, Wang J, Liu X, Wang X, Li H, Gu B, Zhang M, Wang R, Yang Y.   +8 more
europepmc   +1 more source

Interspecies Biofilm Dynamics Among Staphylococci: Inflammatory Contributions to Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Introduction Staphylococcus species are frequently isolated from the sinonasal niche of chronic rhinosinusitis (CRS) patients. While Staphylococcus aureus is often associated with recalcitrant CRS, Staphylococcus epidermidis and Staphylococcus lugdunensis are largely deemed commensal.
Sintayehu Ambachew, Mahnaz Ramezanpour, Clare M. Cooksley, Sholeh Feizi, Muhammed Awad, Kevin Aaron Fenix, Peter‐John Wormald, Alkis J. Psaltis, Sarah Vreugde   +8 more
wiley   +1 more source

Serum Proteomic Analysis Using Gel-Based Liquid Chromatography Tandem Mass Spectrometry Reveals Differences Between Canine Oral Malignancies and Non-Malignant Conditions. [PDF]

Vet Med Sci
Ploypetch S, Roytrakul S, Jaresitthikunchai J, Phaonakrop N, Suriyaphol G.   +4 more
europepmc   +1 more source

KLF14 restrained NLRP3-mediated pyroptosis in sepsis-induced acute lung injury by activating DTX3L. [PDF]

Cent Eur J Immunol
Fan X, Tang L, Xia J, Zhang L, Li Y, Ma Z.   +5 more
europepmc   +1 more source

Monomeric C-reactive Protein as a Mediator of Chronic Inflammation in Obesity. [PDF]

Cureus
Pentek A, Bacârea A.
europepmc   +1 more source