Results 211 to 220 of about 358,202 (249)

Interleukin 18 and Interleukin 18 Binding Protein: Possible Role in Immunosuppression of Chronic Renal Failure

Blood Purification, 2003
Although interleukin (IL)-18 is a member of the IL-1 family of ligands, IL-18 appears to have unique characteristics, particularly in the regulation of the T helper type 1 (Th1) response. Th1 responses are required for tumor surveillance, killing intracellular organisms, and to provide help for antibody production.
Charles A, Dinarello, Daniela, Novick, Menachem, Rubinstein, Gerhard, Lonnemann   +3 more
openaire   +2 more sources

Circulating concentrations of interleukin‐18, interleukin‐18 binding protein, and γ interferon in patients with alcoholic hepatitis

Liver International, 2004
Abstract: Background: Alcoholic hepatitis (AH) is associated with dysregulated inflammatory and immune responses. interleukin‐18 (IL‐18), described as γ interferon (γIFN)‐inducible factor, and its natural antagonist, IL‐18 binding protein (IL‐18 BP), has not been fully studied in patients with AH.
Spahr, Laurent, Garcia, Irene, Bresson-Hadni, Solange, Rubbia-Brandt, Laura, Guler, Reto, Olleros, Maria, Chvatchko, Yolande, Hadengue, Antoine   +7 more
openaire   +5 more sources

Novel targets for interleukin 18 binding protein

Annals of the Rheumatic Diseases, 2001
Interleukin 18 (IL18) is related to the IL1 family by structure, receptors, signalling molecules, and function. IL18 induces gene expression and synthesis of tumour necrosis factor (TNF), IL1, Fas ligand, several chemokines, and vascular adhesion molecules.
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Interleukin-18, Interleukin-18 Gene Polymorphisms and Interleukin18 Binding Protein in Children and Adolescents with Immune Thrombocytopenia

QJM: An International Journal of Medicine, 2023
Background Immune thrombocytopenia (ITP) is an autoimmune illness characterized by an aberrant T cell response, which is supported by autoreactive B cell growth and differentiation. IL-18 expression has been linked to a number of autoimmune and inflammatory illnesses.
Galila Mohamed Mokhtar, Mohamad Mostafa Altawil, Tarek Mostafa Kamal, Nevine Gamal Andrawes, Mona Fathy Abd Elfatah, Waleed Abd El-Wahab Fayed, Khadiga Yehia Eltonbary   +6 more
openaire   +1 more source

Interleukin-18, interleukin-18 binding protein and impaired production of interferon-g in chronic renal failure

Clinical Nephrology, 2003
Uremia is associated with suppressed cellular immune responses, manifested, in part, by impaired interferon-gamma (IFNgamma) production. We investigated the influence of kidney function on plasma levels of interleukin-18 binding protein (IL-18BP), the naturally occurring inhibitor of IL-18.Plasma levels of IL-18, IL-18BP and IFNgamma were measured by ...
G, Lonnemann, D, Novick, M, Rubinstein, C A, Dinarello   +3 more
openaire   +2 more sources

Plasma Levels of Interleukin-18 and Interleukin-18 Binding Protein Are Elevated in Patients with Chronic Liver Disease

Journal of Clinical Immunology, 2002
Interleukin 18 (IL-18) is a recently described proinflammatory cytokine. In mouse models it has been shown to play a key role in the development of liver injury. IL-18 binding protein (IL-18BP) is a naturally occurring antagonist of IL-18. In this study we investigated whether IL-18/IL-18BP levels are altered in patients with chronic liver disease (CLD)
Othmar, Ludwiczek, Arthur, Kaser, Daniela, Novick, Charles A, Dinarello, Menachem, Rubinstein, Wolfgang, Vogel, Herbert, Tilg   +6 more
openaire   +2 more sources

Imbalance of Interleukin-18 and Interleukin-18 Binding Protein in Patients with IgA Nephropathy Implicating Renal Vasculopathy

Clinical Laboratory, 2015
Interleukin-18 (IL-18) is a proinflammatory cytokine which induces interferon-γ production and plays a crucial role in immune systems. IL-18 binding protein (IL-18BP) is a naturally occurring inhibitor of IL-18. The aim was to investigate the involvement of IL-18 and IL-18BP in IgA nephropathy (IgAN).Serum samples from 21 IgAN patients and 16 ...
Chie, Shimizu, Koichi, Matsumoto, Takayuki, Fujita, Yoshinobu, Fuke, Masayoshi, Soma   +4 more
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The Impact of Prolonged Strenuous Endurance Exercise on Interleukin 18 and Interleukin 18 Binding Protein in Recreational Cyclists

International Journal of Sports Medicine, 2005
Interleukin 18 (IL-18) is an important pro-inflammatory cytokine in the early phase of human immune response to microbial infections. The influence of strenuous exercise on the intrinsic balance of IL-18 and its endogenous antagonist IL-18 binding protein (IL-18 BP) is unknown, but could be of major relevance for the athlete's immune function ...
G, Neumayr, O, Ludwiczek, H, Hoertnagl, R, Pfister, G, Mitterbauer, A, Moschen, D, Novick, M, Rubinstein, H, Tilg   +8 more
openaire   +2 more sources

Rat Interleukin-18 Binding Protein: Cloning, Expression, and Characterization

Journal of Interferon & Cytokine Research, 2002
Interleukin-18 binding protein (IL-18BP) is a constitutively expressed and secreted protein that lacks a transmembrane domain. IL-18BP binds specifically to mature IL-18 and inhibits its activity. To study the immunomodulating role of IL-18BP in models of autoimmune diseases in rats, we cloned and characterized rat IL-18BP.
Sin-Hyeog, Im, Soo-Hyun, Kim, Tania, Azam, Natarajan, Venkatesh, Charles A, Dinarello, Sara, Fuchs, Miriam C, Souroujon   +6 more
openaire   +2 more sources

Interleukin-18 Binding Protein in the Sera of Patients with Wegener’s Granulomatosis

Journal of Clinical Immunology, 2008
In the present study, we examined the levels of the pro-inflammatory cytokine IL-18 and its natural inhibitor, the IL-18 binding protein (IL-18BP), in sera of Wegener's granulomatosis (WG) patients at various stages of the disease.Sera from eight consecutive biopsy-proven systemic WG patients (four men and four women; age at diagnosis 58.4 +/- 13.8 ...
D, Novick, D, Elbirt, C A, Dinarello, M, Rubinstein, Z M, Sthoeger   +4 more
openaire   +2 more sources