Results 221 to 230 of about 358,202 (249)

Interleukin-18 binding protein therapy is protective in adriamycin nephropathy

American Journal of Physiology-Renal Physiology, 2013
Adriamycin nephropathy (AN) is an experimental model of focal segmental glomerulosclerosis (FSGS) in which macrophages are considered to play a pathogenic role. We hypothesize that interleukin-18 (IL-18), largely derived from macrophages, is a key contributor to kidney injury in AN and a potential therapeutic target. In this study, BALB/c mice received
Kate R, Wyburn, Steven J, Chadban, Tony, Kwan, Stephen I, Alexander, Huiling, Wu   +4 more
openaire   +2 more sources

Plasma interleukin-18/interleukin-18 binding protein ratio in Chinese with NAFLD.

Hepato-gastroenterology, 2010
The liver has been recognized as a major target of injury in patients with metabolic syndrome and non-alcoholic fatty liver disease has even been considered the hepatic manifestation of metabolic syndrome. Pathogenesis of non-alcoholic fatty liver disease remained unclear.
Yuan, Li, Zhang, Li-Li, Li, Qin, Wang, Ying   +3 more
openaire   +1 more source

Interleukin 18–binding protein ameliorates liver ischemia–reperfusion injury

Journal of Surgical Research, 2016
The aim of this study was to investigate the possible protective effect of interleukin 18-binding protein (IL-18BP) on ischemia-reperfusion (I/R)-induced liver injury in experimental rat models. Liver is one of the most affected organs from I/R process.
Ahmet, Bal, Yucel, Gonul, Omer, Hazman, Ahmet, Kocak, Mehmet Fatih, Bozkurt, Sezgin, Yilmaz, Serdar, Kokulu, Oya, Oruc, Kasim, Demir   +8 more
openaire   +3 more sources

Imbalance of interleukin 18 and interleukin 18 binding protein in patients with lupus nephritis.

Cellular & molecular immunology, 2007
To evaluate the balance status of interleukin 18 (IL-18) and interleukin 18 binding protein (IL-18BP) in circulation in patients with lupus nephritis (LN) and primary nephrotic syndrome (PNS), plasma levels as well as mRNA expression in peripheral blood mononuclear cells (PBMCs) of IL-18 and IL-18BP were measured by ELISA and RT-PCR respectively.
Dong, Liang, Wenfeng, Ma, Cuiwei, Yao, Huafeng, Liu, Xiaowen, Chen   +4 more
openaire   +1 more source

High circulating levels of free interleukin-18 in patients with active SLE in the presence of elevated levels of interleukin-18 binding protein

Journal of Autoimmunity, 2010
Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies particularly to nuclear antigens and by an abnormal production of proinflammatory cytokines. In the present study, we measured the levels of the proinflammatory cytokine IL-18 and its natural inhibitor, the IL-18 binding protein (IL-18BP), in ...
Daniela, Novick, Daniel, Elbirt, Galit, Miller, Charles A, Dinarello, Menachem, Rubinstein, Zev M, Sthoeger   +5 more
openaire   +2 more sources

Ratios between the levels of interleukin 18, free interleukin 18 and interleukin 18 binding protein depending on severity and outcome of COVID-19

Bulletin of Experimental Biology and Medicine, 2023
А. А. Korotaeva, E. V. Samoilova, N. V. Pogosova, A. G. Fesenko, S. V. Evchenko, F. N. Paleev   +5 more
openaire   +1 more source

Interleukin-18 Binding Protein

2014
Daniela Novick, Soohyun Kim, Charles A. Dinarello   +2 more
openaire   +1 more source

High circulating levels of interleukin-18 binding protein indicate the severity of glomerular involvement in systemic lupus erythematosus

Modern Rheumatology, 2012
Yoshinobu Fuke, Fujita Takayuki, Soma Masayoshi   +2 more
exaly   +2 more sources

A soluble binding protein specific for interleukin 1β is produced by activated mononuclear cells

Cytokine, 1990
Gordon W Duff, J A Symons, Julian A Symons   +2 more
exaly  

Interleukin 10 and Heart Fatty Acid-Binding Protein as Early Outcome Predictors in Patients With Traumatic Brain Injury

Frontiers in Neurology, 2020
Virginia Newcombe, Riikka Takala, Mark Van Gils   +2 more
exaly