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Cloning and expression of interleukin-18 binding protein
FEBS Letters, 1999 Interleukin‐18 binding protein is a novel glycoprotein that we successfully cloned and expressed. First, murine interleukin‐18 binding protein was purified from the sera of mice with endotoxin shock using ligand affinity chromatography. The murine interleukin‐18 binding protein cDNA was cloned after RT‐PCR using mixed primer pair sequences based on ...
Tadao Tanimoto +2 more
exaly +4 more sources
Liver International, 2004 Abstract: Background: Alcoholic hepatitis (AH) is associated with dysregulated inflammatory and immune responses. interleukin‐18 (IL‐18), described as γ interferon (γIFN)‐inducible factor, and its natural antagonist, IL‐18 binding protein (IL‐18 BP), has not been fully studied in patients with AH.
Laurent Spahr, Reto Guler, Irene Garcia
exaly +7 more sources
Journal of International Medical Research, 2011 The balance between interleukin-18 (IL-18) and its endogenous antagonist, IL-18 binding protein (IL-18BP), was evaluated in children with Henoch-Schönlein purpura (HSP). Plasma IL-18 and IL-18BP levels and peripheral blood mononuclear cell IL-18 mRNA expression were significantly higher in patients with active HSP ( n = 30) than in healthy controls ( n
Y B Wang
exaly +3 more sources
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British Journal of Haematology, 2009
SummaryTo evaluate the balance of interleukin IL18 and its endogenous antagonist IL18 binding protein (IL18BP) in patients with idiopathic thrombocytopenic purpura (ITP), plasma IL18, IL18BP, interferon gamma (IFNG) and IL4 levels, as well as platelet counts were measured in patients with active ITP (n = 23), ITP in remission (n = 21) and in healthy ...
Ming Hou, Ning-Ning Shan, Jun Peng
exaly +3 more sources
SummaryTo evaluate the balance of interleukin IL18 and its endogenous antagonist IL18 binding protein (IL18BP) in patients with idiopathic thrombocytopenic purpura (ITP), plasma IL18, IL18BP, interferon gamma (IFNG) and IL4 levels, as well as platelet counts were measured in patients with active ITP (n = 23), ITP in remission (n = 21) and in healthy ...
Ming Hou, Ning-Ning Shan, Jun Peng
exaly +3 more sources
Inflammatory Bowel Diseases, 2008
Interleukin-18 (IL-18) is increased in the inflamed mucosa of patients with Crohn's disease (CD). The balance between this pleiotropic proinflammatory cytokine and its natural inhibitor, IL-18-binding protein (IL-18BP), may contribute to the pathogenesis of inflammatory bowel disease (IBD).Serum and mucosal biopsies were collected from children with ...
Daniela Novick +2 more
exaly +3 more sources
Interleukin-18 (IL-18) is increased in the inflamed mucosa of patients with Crohn's disease (CD). The balance between this pleiotropic proinflammatory cytokine and its natural inhibitor, IL-18-binding protein (IL-18BP), may contribute to the pathogenesis of inflammatory bowel disease (IBD).Serum and mucosal biopsies were collected from children with ...
Daniela Novick +2 more
exaly +3 more sources
Blood Purification, 2003
Although interleukin (IL)-18 is a member of the IL-1 family of ligands, IL-18 appears to have unique characteristics, particularly in the regulation of the T helper type 1 (Th1) response. Th1 responses are required for tumor surveillance, killing intracellular organisms, and to provide help for antibody production.
Charles A, Dinarello +3 more
openaire +2 more sources
Although interleukin (IL)-18 is a member of the IL-1 family of ligands, IL-18 appears to have unique characteristics, particularly in the regulation of the T helper type 1 (Th1) response. Th1 responses are required for tumor surveillance, killing intracellular organisms, and to provide help for antibody production.
Charles A, Dinarello +3 more
openaire +2 more sources
QJM: An International Journal of Medicine, 2023
Background Immune thrombocytopenia (ITP) is an autoimmune illness characterized by an aberrant T cell response, which is supported by autoreactive B cell growth and differentiation. IL-18 expression has been linked to a number of autoimmune and inflammatory illnesses.
Galila Mohamed Mokhtar +6 more
openaire +1 more source
Background Immune thrombocytopenia (ITP) is an autoimmune illness characterized by an aberrant T cell response, which is supported by autoreactive B cell growth and differentiation. IL-18 expression has been linked to a number of autoimmune and inflammatory illnesses.
Galila Mohamed Mokhtar +6 more
openaire +1 more source