Results 251 to 260 of about 65,808,146 (287)

Novel targets for interleukin 18 binding protein

Annals of the Rheumatic Diseases, 2001
Interleukin 18 (IL18) is related to the IL1 family by structure, receptors, signalling molecules, and function. IL18 induces gene expression and synthesis of tumour necrosis factor (TNF), IL1, Fas ligand, several chemokines, and vascular adhesion molecules.
openaire   +2 more sources

Plasma Levels of Interleukin-18 and Interleukin-18 Binding Protein Are Elevated in Patients with Chronic Liver Disease

Journal of Clinical Immunology, 2002
Interleukin 18 (IL-18) is a recently described proinflammatory cytokine. In mouse models it has been shown to play a key role in the development of liver injury. IL-18 binding protein (IL-18BP) is a naturally occurring antagonist of IL-18. In this study we investigated whether IL-18/IL-18BP levels are altered in patients with chronic liver disease (CLD)
Othmar, Ludwiczek, Arthur, Kaser, Daniela, Novick, Charles A, Dinarello, Menachem, Rubinstein, Wolfgang, Vogel, Herbert, Tilg   +6 more
openaire   +2 more sources

Imbalance of Interleukin-18 and Interleukin-18 Binding Protein in Patients with IgA Nephropathy Implicating Renal Vasculopathy

Clinical Laboratory, 2015
Interleukin-18 (IL-18) is a proinflammatory cytokine which induces interferon-γ production and plays a crucial role in immune systems. IL-18 binding protein (IL-18BP) is a naturally occurring inhibitor of IL-18. The aim was to investigate the involvement of IL-18 and IL-18BP in IgA nephropathy (IgAN).Serum samples from 21 IgAN patients and 16 ...
Chie, Shimizu, Koichi, Matsumoto, Takayuki, Fujita, Yoshinobu, Fuke, Masayoshi, Soma   +4 more
openaire   +2 more sources

The Impact of Prolonged Strenuous Endurance Exercise on Interleukin 18 and Interleukin 18 Binding Protein in Recreational Cyclists

International Journal of Sports Medicine, 2005
Interleukin 18 (IL-18) is an important pro-inflammatory cytokine in the early phase of human immune response to microbial infections. The influence of strenuous exercise on the intrinsic balance of IL-18 and its endogenous antagonist IL-18 binding protein (IL-18 BP) is unknown, but could be of major relevance for the athlete's immune function ...
G, Neumayr, O, Ludwiczek, H, Hoertnagl, R, Pfister, G, Mitterbauer, A, Moschen, D, Novick, M, Rubinstein, H, Tilg   +8 more
openaire   +2 more sources

Interleukin-18, interleukin-18 binding protein and impaired production of interferon-g in chronic renal failure

Clinical Nephrology, 2003
Uremia is associated with suppressed cellular immune responses, manifested, in part, by impaired interferon-gamma (IFNgamma) production. We investigated the influence of kidney function on plasma levels of interleukin-18 binding protein (IL-18BP), the naturally occurring inhibitor of IL-18.Plasma levels of IL-18, IL-18BP and IFNgamma were measured by ...
G, Lonnemann, D, Novick, M, Rubinstein, C A, Dinarello   +3 more
openaire   +2 more sources

Rat Interleukin-18 Binding Protein: Cloning, Expression, and Characterization

Journal of Interferon & Cytokine Research, 2002
Interleukin-18 binding protein (IL-18BP) is a constitutively expressed and secreted protein that lacks a transmembrane domain. IL-18BP binds specifically to mature IL-18 and inhibits its activity. To study the immunomodulating role of IL-18BP in models of autoimmune diseases in rats, we cloned and characterized rat IL-18BP.
Sin-Hyeog, Im, Soo-Hyun, Kim, Tania, Azam, Natarajan, Venkatesh, Charles A, Dinarello, Sara, Fuchs, Miriam C, Souroujon   +6 more
openaire   +2 more sources

Interleukin-18 binding protein therapy is protective in adriamycin nephropathy

American Journal of Physiology-Renal Physiology, 2013
Adriamycin nephropathy (AN) is an experimental model of focal segmental glomerulosclerosis (FSGS) in which macrophages are considered to play a pathogenic role. We hypothesize that interleukin-18 (IL-18), largely derived from macrophages, is a key contributor to kidney injury in AN and a potential therapeutic target. In this study, BALB/c mice received
Kate R, Wyburn, Steven J, Chadban, Tony, Kwan, Stephen I, Alexander, Huiling, Wu   +4 more
openaire   +2 more sources

Interleukin-18 Binding Protein in the Sera of Patients with Wegener’s Granulomatosis

Journal of Clinical Immunology, 2008
In the present study, we examined the levels of the pro-inflammatory cytokine IL-18 and its natural inhibitor, the IL-18 binding protein (IL-18BP), in sera of Wegener's granulomatosis (WG) patients at various stages of the disease.Sera from eight consecutive biopsy-proven systemic WG patients (four men and four women; age at diagnosis 58.4 +/- 13.8 ...
D, Novick, D, Elbirt, C A, Dinarello, M, Rubinstein, Z M, Sthoeger   +4 more
openaire   +2 more sources

Plasma interleukin-18/interleukin-18 binding protein ratio in Chinese with NAFLD.

Hepato-gastroenterology, 2010
The liver has been recognized as a major target of injury in patients with metabolic syndrome and non-alcoholic fatty liver disease has even been considered the hepatic manifestation of metabolic syndrome. Pathogenesis of non-alcoholic fatty liver disease remained unclear.
Yuan, Li, Zhang, Li-Li, Li, Qin, Wang, Ying   +3 more
openaire   +1 more source

Imbalance of interleukin 18 and interleukin 18 binding protein in patients with lupus nephritis.

Cellular & molecular immunology, 2007
To evaluate the balance status of interleukin 18 (IL-18) and interleukin 18 binding protein (IL-18BP) in circulation in patients with lupus nephritis (LN) and primary nephrotic syndrome (PNS), plasma levels as well as mRNA expression in peripheral blood mononuclear cells (PBMCs) of IL-18 and IL-18BP were measured by ELISA and RT-PCR respectively.
Dong, Liang, Wenfeng, Ma, Cuiwei, Yao, Huafeng, Liu, Xiaowen, Chen   +4 more
openaire   +1 more source