Results 261 to 270 of about 548,210 (297)

Interleukin-18, interleukin-18 binding protein and impaired production of interferon-g in chronic renal failure

Clinical Nephrology, 2003
Uremia is associated with suppressed cellular immune responses, manifested, in part, by impaired interferon-gamma (IFNgamma) production. We investigated the influence of kidney function on plasma levels of interleukin-18 binding protein (IL-18BP), the naturally occurring inhibitor of IL-18.Plasma levels of IL-18, IL-18BP and IFNgamma were measured by ...
G, Lonnemann, D, Novick, M, Rubinstein, C A, Dinarello   +3 more
openaire   +2 more sources

Circulating concentrations of interleukin‐18, interleukin‐18 binding protein, and γ interferon in patients with alcoholic hepatitis

Liver International, 2004
Abstract: Background: Alcoholic hepatitis (AH) is associated with dysregulated inflammatory and immune responses. interleukin‐18 (IL‐18), described as γ interferon (γIFN)‐inducible factor, and its natural antagonist, IL‐18 binding protein (IL‐18 BP), has not been fully studied in patients with AH.
Spahr, Laurent, Garcia, Irene, Bresson-Hadni, Solange, Rubbia-Brandt, Laura, Guler, Reto, Olleros, Maria, Chvatchko, Yolande, Hadengue, Antoine   +7 more
openaire   +5 more sources

Interleukin-18 binding protein therapy is protective in adriamycin nephropathy

American Journal of Physiology-Renal Physiology, 2013
Adriamycin nephropathy (AN) is an experimental model of focal segmental glomerulosclerosis (FSGS) in which macrophages are considered to play a pathogenic role. We hypothesize that interleukin-18 (IL-18), largely derived from macrophages, is a key contributor to kidney injury in AN and a potential therapeutic target. In this study, BALB/c mice received
Kate R, Wyburn, Steven J, Chadban, Tony, Kwan, Stephen I, Alexander, Huiling, Wu   +4 more
openaire   +2 more sources

Imbalance of Interleukin-18 and Interleukin-18 Binding Protein in Patients with IgA Nephropathy Implicating Renal Vasculopathy

Clinical Laboratory, 2015
Interleukin-18 (IL-18) is a proinflammatory cytokine which induces interferon-γ production and plays a crucial role in immune systems. IL-18 binding protein (IL-18BP) is a naturally occurring inhibitor of IL-18. The aim was to investigate the involvement of IL-18 and IL-18BP in IgA nephropathy (IgAN).Serum samples from 21 IgAN patients and 16 ...
Chie, Shimizu, Koichi, Matsumoto, Takayuki, Fujita, Yoshinobu, Fuke, Masayoshi, Soma   +4 more
openaire   +2 more sources

Plasma Levels of Interleukin-18 and Interleukin-18 Binding Protein Are Elevated in Patients with Chronic Liver Disease

Journal of Clinical Immunology, 2002
Interleukin 18 (IL-18) is a recently described proinflammatory cytokine. In mouse models it has been shown to play a key role in the development of liver injury. IL-18 binding protein (IL-18BP) is a naturally occurring antagonist of IL-18. In this study we investigated whether IL-18/IL-18BP levels are altered in patients with chronic liver disease (CLD)
Othmar, Ludwiczek, Arthur, Kaser, Daniela, Novick, Charles A, Dinarello, Menachem, Rubinstein, Wolfgang, Vogel, Herbert, Tilg   +6 more
openaire   +2 more sources

The Impact of Prolonged Strenuous Endurance Exercise on Interleukin 18 and Interleukin 18 Binding Protein in Recreational Cyclists

International Journal of Sports Medicine, 2005
Interleukin 18 (IL-18) is an important pro-inflammatory cytokine in the early phase of human immune response to microbial infections. The influence of strenuous exercise on the intrinsic balance of IL-18 and its endogenous antagonist IL-18 binding protein (IL-18 BP) is unknown, but could be of major relevance for the athlete's immune function ...
G, Neumayr, O, Ludwiczek, H, Hoertnagl, R, Pfister, G, Mitterbauer, A, Moschen, D, Novick, M, Rubinstein, H, Tilg   +8 more
openaire   +2 more sources

Ectromelia, vaccinia and cowpox viruses encode secreted interleukin-18-binding proteins

Microbiology, 2000
Interleukin-18 (IL-18) is a proinflammatory cytokine that plays a key role in the activation of natural killer and T helper 1 cell responses principally by inducing interferon-γ (IFN-γ). Human and mouse secreted IL-18-binding proteins (IL-18BPs) have recently been described which block IL-18 activity but have no sequence similarity to membrane IL-18 ...
V P, Smith, N A, Bryant, A, Alcamí
openaire   +2 more sources

Plasma interleukin-18/interleukin-18 binding protein ratio in Chinese with NAFLD.

Hepato-gastroenterology, 2010
The liver has been recognized as a major target of injury in patients with metabolic syndrome and non-alcoholic fatty liver disease has even been considered the hepatic manifestation of metabolic syndrome. Pathogenesis of non-alcoholic fatty liver disease remained unclear.
Yuan, Li, Zhang, Li-Li, Li, Qin, Wang, Ying   +3 more
openaire   +1 more source

Evolution of interleukin-18 binding proteins and interleukin-1 receptor, type II proteins

International Journal of Molecular Medicine, 2005
Interleukin-18 (IL-18) is one of the pivotal cytokines controlling the defense mechanism called inflammation. As a first step to develop proteins for controlling the IL-18 level, we initiated a study of IL-18-binding proteins (IL-18BPs). Twenty-four IL-18BP family members, 11 from vertebrates and 13 from chordopoxviruses, were picked from the NCBI ...
Makoto, Watanabe, Naohisa, Goto, Yuko, Watanabe, Seiji, Nishiguchi, Kazunori, Shimada, Teruo, Yasunga, Hiromichi, Yamanishi   +6 more
openaire   +2 more sources

Inflammatory status in sepsis alters efficacy of interleukin-18 binding protein therapy*

Critical Care Medicine, 2003
Sepsis remains a serious clinical problem, and multiple attempts at blocking inflammation have failed to decrease mortality rate. Interleukin-18 has been demonstrated to be an important component of the innate immune response to bacterial infections.Previous work demonstrated that elevated plasma concentrations of interleukin-6 obtained in the first 6 ...
Daniel G, Remick, Gerald E, Bolgos, Javed, Siddiqui   +2 more
openaire   +2 more sources