Results 101 to 110 of about 22,453,438 (395)

The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules [PDF]

, 1992
Recent studies have demonstrated that the CD3-ζ subunit of the T cell antigen receptor (TCR) complex is involved in signal transduction. However, the function of the remaining invariant subunits, CD3-γ, -δ, and , is still poorly understood.
Alarcon, Anderson, Baniyash, Bauer, Benhamou, Berkhout, Bernot, Bill, Blank, Blumberg, Bonifacino, Bonifacino, Cantrell, Chomczinski, Clayton, Clevers, Clevers, Cosson, De la Herra, Downward, Engel, Finkel, Frank, Gascoigne, Gillis, Goding, Gold, Green, Gunning, Gunter, Hartman, Haser, Herman, Hermanson, Hyman, Irving, Jacobson, Jin, June, Kappler, Kashiwamura, Klausner, Koning, Krissansen, Küster, Labit, Lanier, Leo, Letourneur, Letourneur, Malissen, Manolios, Mercép, Mustelin, Nakayama, O'Shea, Orloff, Orloff, Ortega, Park, Pullen, Ra, Reth, Reth, Romeo, Saito, Sakaguchi, Samelson, Samelson, Samelson, Samelson, Sharp, Siegel, Sussman, Van den Elsen, Vivier, Vivier, Weiss, Weissman, White, Zamoyska   +80 more
core   +2 more sources

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation

Journal of Experimental Medicine, 1991
A successful immune response requires intercellular contact between T and B lymphocytes. We recently showed that CD28, a T cell surface protein that regulates an activation pathway, could mediate intercellular adhesion with activated B cells by ...
P. Linsley, W. Brady, L. Grosmaire, A. Aruffo, N. Damle, J. Ledbetter   +5 more
semanticscholar   +1 more source

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

Interleukin-2 receptor and ovarian cancer. [PDF]

, 1993
Interleukin-2 receptor (IL-2R) can be detected in serum. We estimated the IL-2R in the serum of 78 women, of whom 30 were diagnosed as having malignant ovarian tumours, five had non ovarian tumours, one had a negative second look laparotomy, 11 had ...
Kennedy, J. H., McKillop, J. H., Owens, O. J., Taggart, C., Walker, J. J., Wilson, R.   +5 more
core   +2 more sources

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

Differential Interleukin-2 Transcription Kinetics Render Mouse but Not Human T Cells Vulnerable to Splicing Inhibition Early after Activation [PDF]

, 2019
T cells are nodal players in the adaptive immune response against pathogens and malignant cells. Alternative splicing plays a crucial role in T cell activation, which is analyzed mainly at later time points upon stimulation. Here we have discovered a 2-h
Bose, D., Heyd, F., Meinke, S., Neumann, A., Timmermann, B.   +4 more
core   +2 more sources

Mechanistic and structural insight into the functional dichotomy between interleukin-2 and interleukin-15

Nature Immunology, 2012
Interleukin 15 (IL-15) and IL-2 have distinct immunological functions even though both signal through the receptor subunit IL-2Rβ and the common γ-chain (γc).
Aaron M. Ring, Jian-Xin Lin, D. Feng, S. Mitra, M. Rickert, Gregory R. Bowman, Vijay S. Pande, Peng Li, Ignacio Moraga, R. Spolski, E. Özkan, Warren J. Leonard, K. Garcia   +12 more
semanticscholar   +1 more source

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism [PDF]

, 2011
SummaryIn cytotoxic T cells (CTL), Akt, also known as protein kinase B, is activated by the T cell antigen receptor (TCR) and the cytokine interleukin 2 (IL-2). Akt can control cell metabolism in many cell types but whether this role is important for CTL
Ahmed, Andrew N. Macintyre, Araki, Bachmann, Bain, Bayascas, Bayascas, Carlson, Carmen Feijoo, Caryll M. Waugh, Castellino, Cham, Cornish, Cruz-Guilloty, D'Souza, David Finlay, Doreen A. Cantrell, Fabre, Finlay, Fox, Garçon, Gavin Preston, Green, Hand, Hendriks, Jacobs, Janas, Jarmin, Juntilla, Kaech, Kalia, Kelly, Kerdiles, Klaus Okkenhaug, Kurts, Lin, Linda V. Sinclair, Liu, Maciver, Malek, Manjunath, Mao, Obar, Ouyang, Pearce, Peter Tamas, Pipkin, Pircher, Prlic, Rao, Rathmell, Saeed, Saibil, Sinclair, Soond, Tamás, Waugh, Williams, Williams   +58 more
core   +3 more sources

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source