Results 31 to 40 of about 22,558,942 (346)

Chlamydia pneumoniae-Induced IFN-Gamma Responses in Peripheral Blood Mononuclear Cells Increase Numbers of CD4+ but Not CD8+ T Effector Memory Cells

Journal of Blood Medicine, 2021
Tamar A Smith-Norowitz, Sarah Shidid, Yitzchok M Norowitz, Stephan Kohlhoff Department of Pediatrics, Division of Infectious Diseases, State University of New York Downstate Medical Center, Brooklyn, NY, 11203, USACorrespondence: Tamar A Smith ...
Smith-Norowitz TA, Shidid S, Norowitz YM, Kohlhoff S   +3 more
doaj  

Use of cellular biotechnologies in treatment metastatic pericarditis at patients with tumors of female reproductive system

Опухоли женской репродуктивной системы, 2014
Malignant pericardial effusions often arise in patients with breаst cancer and ovarian cancer. Sistem antitumor therapy is uneffective in gen- erally and causes side effects.
K. S. Titov, S. M. Volkov, L. V. Demidov, A. N. Gritsay, N. I. Lazareva, M. V. Kiselevskiy, A. P. Nikolayev   +6 more
doaj   +1 more source

Binding of interleukin 2 to gangliosides [PDF]

FEBS Letters, 1984
Exogenous gangliosides inhibit interleukin 2 (IL2)‐dependent growth of a T cell line, AKIL‐1.E8. IL2 activity is retained by columns of ganglioside covalently linked to poly(L‐lysine)‐agarose and is not eluted with ethylene glycol but is completely recovered by elution with 1% SDS. The ability of gangliosides to inhibit IL2 activity is directly related
Patricia B. Ahrens, Helmut Ankel, Gabriella Caldini, Judy Parker, Chitra Krishnamurti   +4 more
openaire   +3 more sources

Treatment of refractory chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation with low-dose interleukin-2

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2015
Refractory chronic graft-versus-host disease (cGVHD) is the complication of allogeneic hematopoietic stem cell transplantation (HCT) that signi ficantly impacts quality of life, may be associated with morbidity and mortality and has limited treatment ...
I. S. Moiseev, E. A. Burmina, Y. A. Tarakanova, Y. R. Zalyalov, A. G. Smirnova, O. V. Pirogova, S. N. Bondarenko, B. V. Afanasyev   +7 more
doaj   +1 more source

An Antibody Targeting Fibroblast Activation Protein Simultaneously Fused to Interleukin-2 and Tumor Necrosis Factor Selectively Localizes to Neoplastic Lesions

Antibodies, 2023
The delivery of specific cytokine payloads to a neoplastic environment employing antibodies able to selectively accumulate at the tumor site represents an attractive strategy to stimulate an immune response to cancer.
Eleonora Prodi, Claudia Comacchio, Ettore Gilardoni, Cesare Di Nitto, Emanuele Puca, Dario Neri, Roberto De Luca   +6 more
doaj   +1 more source

Lymphokine-activated killer cell phenomenon. Lysis of natural killer- resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes

Journal of Experimental Medicine, 1982
Activation in lectin-free interleukin 2 (IL-2) containing supernatants of peripheral blood mononuclear leukocytes (PBL) from cancer patients or normal individuals resulted in expression of cytotoxicity toward 20 of 21 natural killer (NK)-resistant fresh ...
E. Grimm, A. Mazumder, Hua Zhang, S. Rosenberg   +3 more
semanticscholar   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

FEATURES OF CEREBRAL HEMODYNAMICS AND MANIFESTATIONS OF HEPATIC ENCEPHALOPATHY IN CIRRHOSIS OF VIRAL ETIOLOGY AT DIFFERENT COMPENSATION STAGES WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION

Рациональная фармакотерапия в кардиологии, 2017
Aim. To study the features of the parameters of cerebral hemodynamics in extra and intracranial regions in viral hepatic cirrhosis A, B, C classes according to Child-Pugh with different serum levels of interleukin-2, interleukin-6 and tumor necrosis ...
V. E. Kulikov, T. A. Emelina, O. G. Kazakova, K. V. Nikolaevа, M. E. Hapman, M. A. Tonеeva   +5 more
doaj   +1 more source

Development of Type 1 Diabetes in Mice Is Associated with a Decrease in IL-2-Producing ILC3 and FoxP3⁺ Treg in the Small Intestine

Molecules, 2023
Recent data indicate the link between the number and function of T regulatory cells (Treg) in the gut immune tissue and initiation and development of autoimmunity associated with type 1 diabetes (T1D).
Tamara Saksida, Verica Paunović, Ivan Koprivica, Dragica Mićanović, Bojan Jevtić, Natalija Jonić, Ivana Stojanović, Nada Pejnović   +7 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source