Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection. [PDF]
Immunity, 2022 Zander R +12 more
europepmc +2 more sources
Interleukin 21 Controls mRNA and MicroRNA Expression in CD40-Activated Chronic Lymphocytic Leukemia Cells. [PDF]
PLoS ONE, 2015 Several factors support CLL cell survival in the microenvironment. Under different experimental conditions, IL21 can either induce apoptosis or promote CLL cell survival.
Loris De Cecco +11 more
doaj +3 more sources
Interleukin-21 and Interleukin-23 levels in familial Mediterranean Fever before and after treatment: the role of cytokines in disease pathogenesis [PDF]
Scientific ReportsIn a previous study, it has been shown that the population of Th17 lymphocytes was increased in patients with FMF. IL-21 and IL-23 play significant roles in the production and differentiation of Th17 cells.
Mutlu Hizal +7 more
doaj +2 more sources
Elevated plasma interleukin 21 is associated with higher probability and severity of idiopathic membranous nephropathy [PDF]
Journal of Laboratory Medicine, 2023 Interleukin 21 (IL-21) is a receptor participating in innate immunity and correlates with the activation of innate immune cells. We sought to investigate the role of plasma IL-21 in patients with idiopathic membranous nephropathy (IMN).
Liu Miao +11 more
doaj +2 more sources
Egyptian Journal of Medical Human Genetics, 2017 Background: Systemic lupus erythematosus (SLE) is a common autoimmune disorder which commonly results from the combined effects of a large number of genes.
Yasmin Mohamed Ahmed +4 more
doaj +4 more sources
Interleukin 21 Receptor/Ligand Interaction Is Linked to Disease Progression in Pancreatic Cancer [PDF]
Cells, 2019 Pancreatic ductal adenocarcinoma (PDAC) displays a marked fibro-inflammatory microenvironment in which infiltrated immune cells fail to eliminate the tumor cells and often—rather paradoxically—promote tumor progression.
Alica Linnebacher +11 more
doaj +2 more sources
Interleukin-21 and its association with chronic periodontitis.
J Indian Soc Periodontol, 2019 Interleukin-21 (IL-21) is a pleiotropic cytokine, well documented to contribute to the development of Th17 cells which have been shown to play an important role in the pathogenesis of periodontitis. Periodontal disease is a chronic infection of tooth-supporting tissue.This study evaluates the saliva and serum levels of IL-21 in patients with chronic ...
Lokhande RV +3 more
europepmc +4 more sources
Interleukin 21 (IL-21) regulates chronic allograft vasculopathy (CAV) in murine heart allograft rejection. [PDF]
PLoS ONE, 2019 IL-21 is the most recently discovered common gamma-chain cytokine that promotes persistent T-cell responses in chronic infections, autoimmunity and cancer.
Mithun Khattar +6 more
doaj +2 more sources
Interleukin-21 promotes thymopoiesis recovery following hematopoietic stem cell transplantation
Journal of Hematology & Oncology, 2017 Background Impaired T cell reconstitution remains a major deterrent in the field of bone marrow (BM) transplantation (BMT) due to pre-conditioning-induced damages inflicted to the thymi of recipient hosts.
Aurélie Tormo +7 more
doaj +2 more sources
Role of interleukin-21 and interleukin-21 receptor polymorphisms in the treatment of HBeAg-positive chronic hepatitis B patients with peginterferon. [PDF]
Medicine (Baltimore), 2018 The aim of this study was to evaluate the relationship between interleukin-21 (IL-21) and interleukin-21 receptor (IL-21R) polymorphisms and the response to peginterferon alfa (PEG-IFN α) therapy in HBeAg-positive chronic hepatitis B (CHB) patients.A total of 143 HBeAg-positive CHB patients treated for 48 weeks with PEG-IFN α and followed up for 24 ...
Wang X +6 more
europepmc +3 more sources