Results 21 to 30 of about 528,114 (310)
Interleukin‐21 in autoimmune and inflammatory skin diseases [PDF]
European Journal of Immunology, 2023 Abstract Studies on the role of interleukins (ILs) in autoimmune and inflammatory diseases allow for the better understanding of pathologic mechanisms of disease and reshaping of treatment modalities. The development of monoclonal antibodies targeting specific ILs or IL signaling pathways (i.e., anti‐IL‐17/IL‐23 in psoriasis or anti ...
Alberto Mesas‐Fernández +5 more
openalex +3 more sources
Frontiers in Immunology, 2021 Chronic Hepatitis B (CHB) affects over 350 million people worldwide. Current treatment does result in reduced complications; however, a cure (development of antibodies to the S antigen) is not achieved, requiring life-long therapy.
Arshi Khanam +4 more
doaj +1 more source
Pathogens, 2022 Protective immunity against blood-stage Plasmodium infection and the disease malaria depends on antibodies secreted from high-affinity B cells selected during the germinal center (GC) response.
Fionna A. Surette, Noah S. Butler
doaj +1 more source
Definition of a family of tissue-protective cytokines using functional cluster analysis: a proof-of-concept study [PDF]
, 2014 The discovery of the tissue-protective activities of erythropoietin (EPO) has underlined the importance of some cytokines in tissue-protection, repair, and remodeling.
Annenkov, Alexander +4 more
core +13 more sources
Evaluation of plasma IL-21 as a potential biomarker for type 1 diabetes progression
Frontiers in Immunology, 2023 IL-21 is a multifunctional cytokine linked with the pathophysiology of several autoimmune diseases, including type 1 diabetes. In this study, our aim was to examine plasma IL-21 levels in individuals at different stages of type 1 diabetes progression. We
Anna-Mari Schroderus +18 more
doaj +1 more source
Frontiers in Immunology, 2021 ObjectivesT Follicular helper (Tfh) cells, recognized as a distinct CD4+ T cell subset, mediate the development of long-lived humoral immunity via B cell activation/differentiation. Tfh cells play an important role during hepatic viral infection, but its
Bingying Du +6 more
doaj +1 more source
Interleukin-21 Signaling: Functions in Cancer and Autoimmunity [PDF]
Clinical Cancer Research, 2007 Abstract Interleukin-21 (IL-21) is a cytokine with structural and sequence homology to IL-2 and IL-15, yet possesses several biological properties distinct from these cytokines. IL-21 is produced mainly by activated CD4+ T cells and natural killer T cells and mediates its activity by binding to the IL-21 receptor (IL-21R), consisting of ...
Ian D. Davis +5 more
openalex +5 more sources
Peran Reseptor IL-21 (IL-21R) sebagai Target Terapi Pada Penyakit Arteri Perifer
Scripta Score Scientific Medical Journal, 2021 Background: Peripheral Artery Disease (PAD) is caused due to the disruption of blood supply to the periphery caused by blockages in the arteries. PAD is a disease that is difficult to detect and the current therapy is still limited to pharmacological ...
Muhammad Luthfi Adnan
doaj +1 more source
Addition of Interleukin-21 for Expansion of T-Cells for Adoptive Immunotherapy of Murine Melanoma [PDF]
, 2015 We previously demonstrated that interleukin (IL)-7/15 was superior to IL-2 for expansion of T cells in vitrofor adoptive immunotherapy. We sought to ascertain whether IL-21 would further improve yield and therapeutic efficacy of T cells in culture. Naïve
Chatila +6 more
core +6 more sources
Interleukin-21 sustains inflammatory signals that contribute to sporadic colon tumorigenesis [PDF]
, 2015 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.This work received ...
Colantoni, A +13 more
core +3 more sources