Results 91 to 100 of about 576,409 (261)

Interleukin‐22: friend or foe? [PDF]

Immunology & Cell Biology, 2019
Hasnain, Sumaira Z., Begun, Jakob
openaire   +4 more sources

Unsupervised Machine Learning Identifies Shared Biomechanical and Clinical Variation in Individuals with Knee Osteoarthritis and High Body Mass Index

Arthritis Care &Research, EarlyView.
Objective High body mass index (BMI ≥ 27 kg/m2) and aberrant gait biomechanics are primary risk factors for knee osteoarthritis (KOA), yet the specific loading patterns linked to clinical disease features remain unclear. Unsupervised machine learning (ML) was used to identify vertical ground reaction force (vGRF) waveform modes of variation and ...
Ashley N. Buck, J. Elyse Borgert, Hyeon Lee, Liubov Arbeeva, Yvonne M. Golightly, Richard F. Loeser, Leigh F. Callahan, Stephen P. Messier, Brian Pietrosimone, Amanda E. Nelson, James S. Marron   +10 more
wiley   +1 more source

Screening of cellular immunity of T cells in endometrial cancer patients via measurement of interferon gamma, interleukin 22, interleukin 17, interleukin 13, interleukin 10, interleukin 4, interleukin 2, and tumor necrosis factor alpha cytokines

Zanco Journal of Medical Sciences
Background and objective: Endometrial cancer (EC) is considered the sixth most prevalent cancer among women worldwide, with over 400,000 new cases annually, and both its incidence and mortality rates are rising.
Salar Saadi Dizayee, Zahra Abdulqader Amin   +1 more
doaj   +1 more source

Genetically Programmed Shape‐Morphing of Engineered Living Materials

Advanced Functional Materials, EarlyView.
Here, bacterial and mammalian engineered living materials (ELMs) are presented, in which living cells direct genetically programmed and enzymatically mediated shape‐morphing. The resulting deformation and shape‐recovery can be actuated in a genetically controlled manner by an ELM incorporating out‐of‐equilibrium counteracting biochemical reactions with
Jan Becker, Yuchen Liu, Miguel Baños, Rosanne Schmachtenberg, Mahmudul Hasan, Claudia Fink‐Straube, Luai R. Khoury, Wilfried Weber   +7 more
wiley   +1 more source

Alloferon and IL-22 receptor expression regulation on the pathogenesis of imiquimod-induced psoriasis

Scientific Reports
Psoriasis is an immune-mediated inflammatory skin disease. IL-22, a proinflammatory cytokine, is implicated in psoriasis pathogenesis; however, there is currently no established biological treatment targeting IL-22 or its receptor, IL-22Rα.
Tomoyo Agura, Hyejung Jo, Seulgi Shin, Yoojin Jang, Chong Won Choi, In Su Gwak, Jae Seung Kang, Yejin Kim   +7 more
doaj   +1 more source

Serum Interleukin-22 in Iraqi Patients with Crohn’s Disease: Association with Biologic Treatment Status and Clinical Disease Activity

مجلة الكوفة الطبية
Background: Interleukin-22 (IL-22) is an immunologically relevant cytokine in Crohn’s disease (CD), but its circulating clinical significance remains uncertain. This study evaluated serum IL-22 in Iraqi patients with CD and examined its association with
Ghaith Adnan Neamah, Khawlah Abdallah Salman   +1 more
doaj   +1 more source

Protease‐Activated Theranostic Nanomedicine for Endometriosis Treatment

Advanced Functional Materials, EarlyView.
Endometriosis is a chronic gynecological disorder that affects a substantial proportion of reproductive‐aged women. In this study, we identify aberrant overexpression of matrix metalloproteinase‐9 (MMP‐9) in endometriotic lesions and develop a novel multifunctional nanomedicine that integrates MMP‐9‐targeted therapy, ratiometric photoacoustic (PA ...
Panangattukara Prabhakaran Praveen Kumar, Tae Hoon Kim, Hossein Hosseinirad, Maggie Lee, HyeJoo An, Bruce A. Lessey, Daniel Hanavi, Jung‐Ho Shin, Jae‐Wook Jeong, Taeho Kim   +9 more
wiley   +1 more source

Macrophage–Fibroblast Crosstalk Governs Tumor Mechanics, as Revealed by Spatiotemporal Force Mapping in 3D Spheroids

Advanced Healthcare Materials, EarlyView.
This study shows crosstalk among tumor cells, fibroblasts, and macrophages alters the physical forces inside 3D tumor spheroids. Incorporating deformable microparticles in 3D tumor spheroids, the researchers mapped mechanical stresses spatially and with respect to tumor growth (temporally).
Kunal P. Pednekar, Daan Vorselen, Jai Prakash   +2 more
wiley   +1 more source

Anti‐Inflammatory and Neuroactive Effects of Polymer‐Coated Iron Oxide Nanoparticles Functionalized With Interleukin 4 for Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez, Paloma Lozano‐Picazo, María de Lamo‐Atencia, Andrea Ferreras, Esther Benayas‐Martín, Elena Fernández‐López, Marina Sánchez‐Petidier, Verónica Barranco‐Maresca, Víctor Caz, Anne des Rieux, Juliana M. Rosa, María del Puerto Morales, María C. Serrano   +12 more
wiley   +1 more source

The Correlation between the Numerical Status of Th22 Cells and Serum Level of IL-22 with Severity of Ulcerative Colitis

Iranian Journal of Allergy, Asthma and Immunology, 2018
Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease, yet its etiology as well as pathogenesis remain poorly understood. There is increasing evidence that aberrant expression of CD4+T lymphocytes plays an essential role in the ...
Abbas Arj, Mohsen Razavizadeh, Hanieh Mohammadi, Hassan Nikoueinejad, Hossein Akbari   +4 more
doaj