Results 61 to 70 of about 2,200,720 (269)

A Novel Missense Mutation in Oncostatin M Receptor Beta Causing Primary Localized Cutaneous Amyloidosis [PDF]

, 2014
Primary localized cutaneous amyloidosis (PLCA) is a chronic skin disorder, caused by amyloid material deposition in the upper dermis. Autosomal dominant PLCA has been mapped earlier to pathogenic missense mutations in the OSMR gene, which encodes the ...
Amoli, Mahsa M., Ebrahim-Habibi, Azadeh, Haghighi, Alireza, Robati, Reza M., Saeedi, Marjan, Zarrabi, Fariba   +5 more
core   +4 more sources

The antiangiogenic role of the pro-inflammatory cytokine interleukin-31. [PDF]

Oncotarget, 2017
Pro-inflammatory cytokines in the tumor microenvironment are known for their ability to either inhibit or promote cancer progression. Here we evaluated the role of Interleukin-31 (IL31), a protein belonging to the pro-inflammatory IL-6 cytokine family which has been characterized in autoimmune disease, in tumorigenesis.
Davidi S, Fremder E, Kan T, Raviv Z, Timaner M, Karin N, Hershkovitz D, Arohneim A, Shaked Y.   +8 more
europepmc   +4 more sources

A New Itch to Scratch for TSLP [PDF]

, 2014
Atopic dermatitis (AD) is characterized by allergic inflammation and itch. Thymic stromal lymphopoietin (TSLP) is a pro-allergic cytokine implicated in AD.
Turner, Matthew J., Zhou, Baohua
core   +1 more source

Cynomolgus monkey model of interleukin‐31‐induced scratching depicts blockade of human interleukin‐31 receptor A by a humanized monoclonal antibody [PDF]

Experimental Dermatology, 2017
AbstractScratching is an important factor exacerbating skin lesions through the so‐called itch‐scratch cycle in atopic dermatitis (AD). In mice, interleukin (IL)‐31 and its receptor IL‐31 receptor A (IL‐31RA) are known to play a critical role in pruritus and the pathogenesis of AD; however, study of their precise roles in primates is hindered by the ...
Sohei Oyama, Hidetomo Kitamura, Taichi Kuramochi, Yoshinobu Higuchi, Hiroaki Matsushita, Tsukasa Suzuki, Masaaki Goto, Hideki Adachi, Keiko Kasutani, Akihisa Sakamoto, Yuki Iwayanagi, Akihisa Kaneko, Masahiko Nanami, Etsuko Fujii, Keiko Esaki, Yoshiaki Takashima, Shin Shimaoka, Kunihiro Hattori, Yoshiki Kawabe   +18 more
openaire   +2 more sources

Evaluation of the role of interleukin-31 in inflammatory acne vulgaris: a case–control study

Journal of the Egyptian Women’s Dermatologic Society, 2020
Background Acne vulgaris (AV) is a chronic inflammatory disease with multifactorial etiology and a significant psychological disability. Inflammation is a fundamental process in the early and late stage of acne.
Shahira A Ramadan, Dalia M Abdel Halim, Rofaida El-Naggar, Nahed M Ibrahim, Marwa S El-Mesidy   +4 more
doaj   +1 more source

New mechanism underlying IL-31-induced atopic dermatitis [PDF]

, 2018
LBK
Buddenkotte, Joerg, Buhl, Timo, Feld, Micha, Fischer, Michael, Ghetti, Andre, Meng, Jianghui, Miller, Paul, Moriyama, Masaki, Reeh, Peter W., Shan, Chunxu, Steinhoff, Martin, Szöllősi, Attila Gábor, Wang, Jiafu, Zhang, Jingming   +13 more
core   +1 more source

Efficacy and safety of vixarelimab, a human monoclonal oncostatin M receptor β antibody, in moderate-to-severe prurigo nodularis: a randomised, double-blind, placebo-controlled, phase 2a studyResearch in context

EClinicalMedicine, 2023
Summary: Background: Prurigo nodularis is a chronic skin disease characterised by intensely pruritic, hyperkeratotic nodules. Vixarelimab, a human monoclonal antibody, binds to the beta subunit of the oncostatin M receptor, inhibiting signalling of both
Howard Sofen, Robert Bissonnette, Gil Yosipovitch, Jonathan I. Silverberg, Stephen Tyring, Wei Jing Loo, Matthew Zook, Mark Lee, Liangxing Zou, Guang-Liang Jiang, John F. Paolini   +10 more
doaj   +1 more source

Az atópiás dermatitis patomechanizmusa [PDF]

, 2018
L
Steuer-Hajdu, Krisztina, Szegedi, Andrea
core   +1 more source

Regulation of Reactive Oxygen Species and the Antioxidant Protein DJ-1 in Mastocytosis [PDF]

, 2016
Neoplastic accumulation of mast cells in systemic mastocytosis (SM) associates with activating mutations in the receptor tyrosine kinase KIT. Constitutive activation of tyrosine kinase oncogenes has been linked to imbalances in oxidant/antioxidant ...
Bai, Yun, Bandara, Geethani, Beaven, Michael A., Desai, Avanti, Kim, Do-Kyun, Komarow, Hirsh, Kulinski, Joseph M., Metcalfe, Dean D., Olivera, Ana, Prussin, Calman, Schwartz, Lawrence B.   +10 more
core   +5 more sources

Genetic and epigenetic studies of atopic dermatitis [PDF]

, 2016
Additional file 2: References.
Donald Y. M. Leung, Lianghua Bin
core   +3 more sources