Results 41 to 50 of about 657,596 (286)

Optimization of Interleukin-5 Protein Expression in BL21 Strain of Escherichia Coli

مجله دانشکده پزشکی اصفهان, 2020
Background: In asthma, the relationship between number of eosinophils and severity of this disease supports the hypothesis that eosinophil is the major effector cell in inflammation of airway. Evolution of eosinophils is regulated by interlukin-5 (IL-5).
mina Jamalvandi, Hossein Khanahmad, Shiva Irani, Sayad Bastaminejad   +3 more
doaj   +1 more source

The effects of anti-sense interleukin-5 gene transferred by recombinant adeno-associated virus in allergic rats [PDF]

, 2008
The accumulation and infiltration of eosinophils in airways is one of the most important characteristics of asthma, and is mediated partly by secretion of IL-5 from Th2 lymphocytes.
Chao Cao, Daxiong Zeng, Qingfeng Song, Weining Xiong, Xiansheng Liu, Yong Cao, Yongjian Xu   +6 more
core   +1 more source

Bench-to-bedside review: Erythropoietin and its derivatives as therapies in critical care [PDF]

, 2012
Author can archive publisher's pdf. Free via Creative Commons: CC-BENCHTOBEDSIDE-2.0.
Nandra, KK, Patel, NSA, Thiemermann, C
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Uncovering how interleukin-5 and interleukin-23 shape human immune defense against Salmonella enterica Typhi

Journal of Microbiology and Infectious Diseases
Background: Salmonella enterica serotype Typhi remains a major global health concern, particularly in regions with limited resources. Interleukins such as interleukin-5 and interleukin-23 are thought to play pivotal roles in shaping the host's ...
Ruaa Kareem Surhan, Aqeel A. Al-Sadawi, Ali Reyadh Medhat, Ahmed Al Obaidi   +3 more
doaj   +1 more source

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. [PDF]

, 1996
Reversible airway hyperreactivity underlies the pathophysiology of asthma, yet the precise mediators of the response remain unclear. Human studies have correlated aberrant activation of T helper (Th) 2-like effector systems in the airways with disease. A
Corry, DB, Erle, DJ, Folkesson, HG, Locksley, RM, Matthay, MA, Warnock, ML, Wiener-Kronish, JP   +6 more
core  

Glucocorticoids—All-Rounders Tackling the Versatile Players of the Immune System [PDF]

, 2019
Glucocorticoids regulate fundamental processes of the human body and control cellular functions such as cell metabolism, growth, differentiation, and apoptosis.
Agarwal, Al-Mousawi, Allen, Almawi, Anderson, Andreae, Annunziato, Anthony, Arya, Avnir, Avnir, Baatjes, Banchereau, Banuelos, Banuelos, Barnes, Beck, Beck, Belvisi, Bengtsson, Benson, Bentley, Berdeli, Blotta, Borish, Brack, Bradding, Braun, Brozek, Burger, Buttgereit, Buttgereit, Buttgereit, Capell, Chan, Chatham, Chen, Choo, Chung, Clutterbuck, Cohn, Corbera-Bellalta, Cosmi, Cosmi, Crocker, Cronstein, Damsker, Dao Nguyen, Daynes, Daynes, de Castro Kroner, Deng, Dolhain, Dorner, Dougherty, Durham, Eichenauer, Eichhorst, Eklund, Erin, Espigol-Frigole, Fanouriakis, Finotto, Firestein, Firestein, Franchimont, Franchimont, Franco, Gao, Geginat, Gemou-Engesaeth, Gladman, Gomes, Gracie, Gregersen, Greiner, Grindebacke, Guiducci, Gupta, Hadji, Hagan, Hahn, Hamid, Hamid, Hanahan, Haneda, Hartl, Hasegawa, Hawrylowicz, Hehlmann, Heidari, Heiman, Hellmich, Hermann-Kunz, Hernandez-Rodriguez, Hicsonmez, Hirahara, Hoelzer, Hollenberg, Hu, Hussain, Hutchison, Inaba, Ismaili, Jacobi, Jacobi, Jee, Jennette, Jiang, Jin, Jing, John, Jones, Jones, Kansal, Kaplan, Karagiannidis, Kirwan, Klarenbeek, Klassen, Kleiman, Klein, Klimek, Kotake, Kotake, Kovalovsky, Kremer, Kruth, Leppert, Li, Li-Weber, Liberman, Liles, Lim, Lin, Linden, Liu, Loetscher, Lohse, Lugar, Luo, Machold, Maggi, Maneechotesuwan, Manzoni, Martinez-Sanchez, Maruotti, Matsui, Matteson, McDonough, Meagher, Mercieca, Merrill, Miller, Miltenburg, Mitra, Miyasaka, Miyaura, Moallem, Morita, Moynihan, Mozo, Muehling, Munck, Muraro, Murphy, Naseer, Neeck, Neeck, Nicholson, O'Byrne, O'Byrne, Oakley, Oakley, Ochiai, Odendahl, Oppong, Ospelt, Parrillo, Patel, Pawankar, Pearson, Perez-Guerrero, Pers, Picchianti-Diamanti, Pratt, Pratt, Pui, Qin, Quinn, Radich, Rainer, Rak, Ramirez, Rank, Ratman, Refojo, Reichardt, Rider, Ring, Robinson, Robinson, Ronnblom, Ruiz-Arruza, Saadoun, Sallusto, Samson, Samson, Santos, Schacke, Schacke, Scherlinger, Schmitz, Schug, Shah, Shaw, Shlomchik, Siegel, Smith, Smolen, Smolen, Song, Stahn, Stahn, Stellato, Stone, Strehl, Strehl, Tanaka, Terrades-Garcia, Theofilopoulos, Thomas, Thomas, Till, Tuckermann, Turjeman, Ulmansky, Umetsu, van der Geest, van Oosterhout, Vandevyver, Verhoef, Verstappen, von Bernus, von Hertzen, Waknine-Grinberg, Walker, Wang, Wassenberg, Watanabe, Wen, Weyand, Weyand, Wheatley, Wikstrom, Willemze, Wills-Karp, Wills-Karp, Wollenberg, Wollenberg, Wright, Wu, Wuthrich, Xystrakis, Yamamoto, Yan, Yang, Ying, Zubiaga   +268 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Mepolizumab in Chronic Obstructive Pulmonary Disease (COPD): A new frontier in biologic therapy

Saudi Journal of Anaesthesia
Mepolizumab, a comprehensible monoclonal antibody that inhibits interleukin-5 (IL-5), offers a new therapeutic option for a subset of patients with chronic obstructive pulmonary disease (COPD) marked by eosinophilic inflammation.
Arun Mukesh, Konica Chittoria, Ankur Sharma   +2 more
doaj   +1 more source

Profile of reslizumab in eosinophilic disease and its potential in the treatment of poorly controlled eosinophilic asthma [PDF]

, 2013
Peer reviewedPublisher ...
Walsh, Garry Michael
core   +2 more sources