Results 11 to 20 of about 1,282,878 (301)

Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice. [PDF]

, 2012
BackgroundIschemia-reperfusion (I-R) injury is a sterile inflammatory process that is commonly associated with diverse clinical situations such as hemorrhage followed by resuscitation, transient embolic events, and organ transplantation.
Dodd-o, Jeffrey M, Hellman, Judith, Mesa, Kailin R, Prakash, Arun, Wilhelmsen, Kevin, Xu, Fengyun   +5 more
core   +1 more source

Inflammatory Markers Associated With Subclinical Coronary Artery Disease: The Multicenter AIDS Cohort Study. [PDF]

, 2016
BackgroundDespite evidence for higher risk of coronary artery disease among HIV+ individuals, the underlying mechanisms are not well understood. We investigated associations of inflammatory markers with subclinical coronary artery disease in 923 ...
Bahrami, Hossein, Budoff, Matthew, Haberlen, Sabina A, Ketlogetswe, Kerunne, Kingsley, Lawrence, McConnell, Michael V, Palella, Frank, Post, Wendy S, Rezaeian, Pantea, Tracy, Russell, Witt, Mallory D   +10 more
core   +2 more sources

Virus-Like Particle-Mediated Vaccination against Interleukin-13 May Harbour General Anti-Allergic Potential beyond Atopic Dermatitis [PDF]

, 2020
Virus-like particle (VLP)-based anti-infective prophylactic vaccination has been established in clinical use. Although validated in proof-of-concept clinical trials in humans, no VLP-based therapeutic vaccination against self-proteins to modulate chronic
Foerster, John, Molęda, Aleksandra
core   +2 more sources

Placental-mediated increased cytokine response to lipopolysaccharides: a potential mechanism for enhanced inflammation susceptibility of the preterm fetus. [PDF]

, 2012
BackgroundCerebral palsy is a nonprogressive motor impairment syndrome that has no effective cure. The etiology of most cases of cerebral palsy remains unknown; however, recent epidemiologic data have demonstrated an association between fetal neurologic ...
Belkacemi, Louiza, Beloosesky, Ron, Boles, Julie L, Desai, Mina, Ross, Michael G   +4 more
core   +1 more source

Influence of oxidative stress, diaphragm fatigue, and inspiratory muscle training on the plasma cytokine response to maximum sustainable voluntary ventilation [PDF]

, 2014
The influence of oxidative stress, diaphragm fatigue, and inspiratory muscle training (IMT) on the cytokine response to maximum sustainable voluntary ventilation (MSVV) is unknown.
Brown PI, Dean E. Mills, Graham R. Sharpe, Javier T. Gonzalez, Martin J. McPhilimey, Michael A. Johnson, Mizuno M, Neil C. Williams, Palmieri B, Tidball JG, Yvonne A. Barnett   +10 more
core   +1 more source

Fetal skin as a pro-inflammatory organ: Evidence from a primate model of chorioamnionitis. [PDF]

, 2017
BackgroundIntrauterine infection is a primary cause of preterm birth and fetal injury. The pro-inflammatory role of the fetal skin in the setting of intrauterine infection remains poorly characterized. Whether or not inflammation of the fetal skin occurs
Boonkasidecha, Suppawat, Jobe, Alan H, Kallapur, Suhas G, Kannan, Paranthaman Senthamarai, Kemp, Matthew W   +4 more
core   +8 more sources

Assessment of Tocilizumab (Anti–Interleukin‐6 Receptor Monoclonal) as a Potential Treatment for Chronic Antibody‐Mediated Rejection and Transplant Glomerulopathy in HLA‐Sensitized Renal Allograft Recipients

American Journal of Transplantation, 2017
Extending the functional integrity of renal allografts is the primary goal of transplant medicine. The development of donor‐specific antibodies (DSAs) posttransplantation leads to chronic active antibody‐mediated rejection (cAMR) and transplant ...
Jua Choi, O. Aubert, A. Vo, A. Loupy, M. Haas, D. Puliyanda, Irene K Kim, S. Louie, A. Kang, A. Peng, J. Kahwaji, N. Reinsmoen, M. Toyoda, S. Jordan   +13 more
semanticscholar   +1 more source

Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses

Journal of Experimental Medicine, 2019
Spencer et al. report the first description of human IL-6R deficiency in two patients presenting with recurrent infections, atopy, elevated IgE, and abnormal acute-phase responses.
Sarah Spencer, S. Köstel Bal, W. Egner, Hana Lango Allen, S. I. Raza, Chi A. Ma, Meltem Gürel, Y. Zhang, Guangping Sun, R. Sabroe, D. Greene, W. Rae, T. Shahin, Katarzyna Kania, R. Ardy, M. Thian, E. Staples, A. Pecchia-Bekkum, William P M Worrall, J. Stephens, M. Brown, Salih Tuna, M. York, F. Shackley, D. Kerrin, R. Sargur, Alison M Condliffe, H. N. Tipu, H. Kuehn, S. Rosenzweig, E. Turro, S. Tavaré, A. Thrasher, D. Jodrell, Kenneth G. C. Smith, K. Boztug, J. Milner, James E. D. Thaventhiran   +37 more
semanticscholar   +1 more source

Circulating interleukin-6 receptor in patients with sepsis syndrome [PDF]

, 1995
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Clement, C., Deuren, M. van, Frieling, J.T.M., Linden, C.J. van der, Meer, J.W.M. van der, Sauerwein, R.W., Wijdenes, J.   +6 more
core   +2 more sources

Consensus statement on blocking interleukin-6 receptor and interleukin-6 in inflammatory conditions: an update [PDF]

Annals of the Rheumatic Diseases, 2023
Targeting interleukin (IL)-6 has become a major therapeutic strategy in the treatment of immune-mediated inflammatory disease. Interference with the IL-6 pathway can be directed at the specific receptor using anti-IL-6Rα antibodies or by directly inhibiting the IL-6 cytokine.
Daniel Aletaha, Andreas Kerschbaumer, Kastriot Kastrati, Christian Dejaco, Maxime Dougados, Iain B McInnes, Naveed Sattar, Tanja A Stamm, Tsutomu Takeuchi, Michael Trauner, Désirée van der Heijde, Marieke Voshaar, Kevin L Winthrop, Angelo Ravelli, Neil Betteridge, Gerd-Rüdiger R Burmester, Johannes WJ Bijlsma, Vivian Bykerk, Roberto Caporali, Ernest H Choy, Catalin Codreanu, Bernard Combe, Mary K Crow, Maarten de Wit, Paul Emery, Roy M Fleischmann, Cem Gabay, Merete Lund Hetland, Kimme L Hyrich, Annamaria Iagnocco, John D Isaacs, Joel M Kremer, Xavier Mariette, Peter A Merkel, Eduardo F Mysler, Peter Nash, Michael T Nurmohamed, Karel Pavelka, Gyula Poor, Andrea Rubbert-Roth, Hendrik Schulze-Koops, Anja Strangfeld, Yoshiya Tanaka, Josef S Smolen   +43 more
openaire   +11 more sources