Results 21 to 30 of about 1,282,878 (301)

Blockade of interleukin-6 receptor in the periphery promotes rapid and sustained antidepressant actions: a possible role of gut–microbiota–brain axis

Translational Psychiatry, 2017
Depression is a common, severe and chronic psychiatric disease. Although the currently available antidepressants have been used in the treatment of depression, their beneficial effects are limited.
Jiancheng Zhang, W. Yao, Chao Dong, Chun Yang, Q. Ren, M. Ma, Kenji Hashimoto   +6 more
semanticscholar   +1 more source

Interleukin-6/interleukin-6 receptor complex promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells

Stem cell research & therapeutics, 2018
Interleukin-6 (IL-6) with IL-6 receptor (IL-6R) play an important role in the tissue regeneration in vivo, especially bone metabolism. Bone marrow -derived mesenchymal stem cells (BM-MSCs) are multipotent stromal cells, which are main origin of ...
Zhongyu Xie, Su’an Tang, Guiwen Ye, P. Wang, Jinteng Li, Wenjie Liu, Ming Li, Shan Wang, Xiaohua Wu, Shuizhong Cen, Guan Zheng, M. Ma, Yanfeng Wu, Huiyong Shen   +13 more
semanticscholar   +1 more source

Signaling via interleukin-4, receptor alpha chain is required for successful vaccination against schistosomiasis in BALB/c mice [PDF]

, 2001
Radiation-attenuated (RA) schistosome larvae are potent stimulators of innate immune responses at the skin site of exposure (pinna) that are likely to be important factors in the development of Th1-mediated protective immunity.
Anderson S., Anderson S., Anderson S., Artis D., Bancroft A. J., Bancroft A. J., Barner M., Belkaid Y., Brewer J. M., Brombacher F., Coulson P. S., D'Andrea A., de Andres B., Dean D. A., Delgado V., Donaldson D. D., Faquim-Mauro E. L., Galbiati F., Grunig G., Guler M. L., Hilton D. J., Hoffmann K. F., Hsieh C. S., James S. L., Jankovic D., Jankovic D., Jankovic D., King C. L., King C. L., Kopf M., Magram J., Mangold B. L., Matthews D. J., Mattner F., McKenzie G. J., Metwali A., Mohrs M., Mohrs M., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Muchamuel T., Nelms K., Noben-Trauth N., Noben-Trauth N., Noben-Trauth N., O'Garra A., Pearce E. J., Reiner S. L., Scott P., Seder R. A., Sher A., Shibuya K., Smythies L. E., Smythies L. E., Street M., Szabo S. J., Urban J. F., Wilson R. A., Wynn T. A., Wynn T. A., Zurawski G.   +64 more
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Role of Soluble Interleukin-6 Receptor With Interleukin-6 in Human Hematopoiesis

Hematology, 1997
A complex of soluble interleukin-6 receptor (sIL-6R) and interleukin-6 has been shown to play some roles in human hematopoiesis. It activates gp130 signal to stimulate human erythroid, megakaryocytic and primitive hematopoietic progenitor cells, which express gp130 but not IL-6R, in the presence of c-Kit signal mediated by stem cell factor (SCF).
K, Tsuji, T, Nakahata
openaire   +2 more sources

Pro-inflammatory signaling by IL-10 and IL-22: bad habit stirred up by interferons? [PDF]

, 2013
Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of ...
Mühl, Heiko
core   +2 more sources

Association of Interleukin 6 Receptor Variant With Cardiovascular Disease Effects of Interleukin 6 Receptor Blocking Therapy: A Phenome-Wide Association Study

JAMA cardiology, 2018
Importance Electronic health record (EHR) biobanks containing clinical and genomic data on large numbers of individuals have great potential to inform drug discovery.
Tianxi Cai, Yichi Zhang, Y. Ho, N. Link, Jiehuan Sun, Jie Huang, T. Cai, S. Damrauer, Y. Ahuja, J. Honerlaw, L. Costa, P. Schubert, C. Hong, D. Gagnon, Yan V. Sun, Yan V. Sun, J. Gaziano, P. Wilson, Kelly Cho, Philip S. Tsao, C. O’Donnell, K. Liao, M. Gaziano, R. Ramoni, Jim L. Breeling, Kyong-Mi Chang, Grant D Huang, S. Muralidhar, P. Tsao, J. Moser, S. Whitbourne, J. V. Brewer, J. Concato, Stuart R. Warren, Dean P. Argyres, B. Stephens, M. Brophy, Donald E. Humphries, Nhan V Do, S. Shayan, Xuan-Mai T. Nguyen, S. Pyarajan, Elizabeth R. Hauser, Hongyu Zhao, Rachel McArdle, Louis J. Dellitalia, John B. Harley, J. Whittle, J. Beckham, J. Wells, Salvador Gutiérrez, Gretchen Gibson, Laurence S. Kaminsky, G. Villareal, Junzhe Xu, M. Hamner, K. S. Haddock, Sujata Bhushan, Pran R. Iruvanti, M. Godschalk, Zuhair Ballas, M. Buford, Stephen M. Mastorides, Jon Klein, N. Ratcliffe, H. Flórez, Alan Swann, Maureen Murdoch, P. Sriram, S. Kinlay, S. Yeh, Ron Washburn, D. Jhala, Samuel M. Aguayo, David M. Cohen, Satish C. Sharma, John Callaghan, K. Oursler, M. Whooley, Sunil K. Ahuja, Amparo Gutierrez, Ronald Schifman, Jennifer A. Greco, M. Rauchman, Richard Servatius, M. Oehlert, A. Wallbom, Ronald S. Fernando, Trefor Owen Morgan, Todd Stapley, Scott Sherman, Gwenevere Anderson, Elif Sonel, Edward Boyko, Laurence Meyer, Samir K. Gupta, Joseph M. Fayad, Adriana M. Hung, Jack Lichy, Robin A. Hurley, B. Robey, R. Striker   +101 more
semanticscholar   +1 more source

Artery tertiary lymphoid organs control multi-layered territorialized atherosclerosis B cell responses in aged ApoE-/- mice [PDF]

, 2016
Objective: Explore aorta B cell immunity in aged ApoE-/- mice. Approach and Results: Transcript maps, FACS, immunofluorescence analyses, cell transfers, and Ig-ELISPOT assays showed multi-layered atherosclerosis B cell responses in artery tertiary ...
Andreas J.R. Habenicht, Changjun Yin, Christian Weber, Coleen A. McNamara, Desheng Hu, Gianluca Grassia, Kulkarni U, Li Peng, Michael Beer, Pasquale Maffia, Prasad Srikakulapu, Rudolf A. Manz, Sai Vineela Bontha, Sarajo K. Mohanta   +13 more
core   +1 more source

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

The Lancet, 2012
Summary Background A high circulating concentration of interleukin 6 is associated with increased risk of coronary heart disease. Blockade of the interleukin-6 receptor (IL6R) with a monoclonal antibody (tocilizumab) licensed for treatment of rheumatoid ...
D. Swerdlow, M. Holmes, K. Kuchenbaecker, J. Engmann, T. Shah, R. Sofat, Yiran Guo, C. Chung, A. Peasey, R. Pfister, S. Mooijaart, H. Ireland, M. Leusink, C. Langenberg, Kawah Li, J. Palmen, Philip N. Howard, J. Cooper, F. Drenos, J. Hardy, M. Nalls, Y. Li, G. Lowe, Marlene C. W. Stewart, S. Bielinski, J. Peto, N. Timpson, J. Gallacher, M. Dunlop, R. Houlston, I. Tomlinson, I. Tzoulaki, J. Luan, J. Boer, N. Forouhi, N. Onland-Moret, Y. T. van der Schouw, R. Schnabel, J. Hubacek, R. Kubínová, M. Baceviciene, A. Tamošiūnas, A. Pająk, R. Topor-Madry, S. Malyutina, D. Baldassarre, B. Sennblad, E. Tremoli, U. de Faire, L. Ferrucci, Stefania Bandenelli, Toshiko Tanaka, J. Meschia, A. Singleton, G. Navis, Irene Mateo Leach, S. Bakker, R. Gansevoort, I. Ford, S. Epstein, M. Burnett, J. Devaney, J. Jukema, R. Westendorp, Gert Jan de Borst, Y. van der Graaf, P. D. de Jong, A. Mailand-van der Zee, O. Klungel, A. de Boer, P. Doevendans, J. Stephens, C. Eaton, Jennifer G. Robinson, J. Manson, F. Fowkes, Timonthy M Frayling, J. Price, P. Whincup, R. Morris, D. Lawlor, G. Smith, Y. Ben-Shlomo, S. Redline, L. Lange, M. Kumari, N. Wareham, W. Verschuren, E. Benjamin, J. Whittaker, A. Hamsten, F. Dudbridge, J. Delaney, A. Wong, D. Kuh, R. Hardy, B. A. Castillo, John J. Connolly, P. van der Harst, E. Brunner, M. Marmot, C. Wassel, S. Humphries, P. Talmud, M. Kivimaki, F. Asselbergs, M. Voevoda, M. Bobák, H. Pikhart, James G. Wilson, H. Hakonarson, A. Reiner, B. Keating, N. Sattar, A. Hingorani, J. Casas   +115 more
semanticscholar   +1 more source

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis [PDF]

, 2012
Idiopathic pulmonary fibrosis (IPF) is a fatal disease that is unresponsive to current therapies and characterized by excessive collagen deposition and subsequent fibrosis.
Anderson, G.P., Bozinovski, S., Ernst, M.R., Jarnicki, A.G., Jones, J., Knight, D.A., Lau, H.L., Laurent, G.J., McAnulty, R.J., McKenzie, B.S., Mutsaers, S.E., O'Donoghue, R.J.J., Prêle, C.M., Richards, C.D., Rose-John, S., Stumbles, P.A., Thiem, S., Vlahos, R., Wang, B., Zhu, H.J.   +19 more
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Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17

Scientific Reports, 2016
Limited proteolysis of the Interleukin-6 Receptor (IL-6R) leads to the release of the IL-6R ectodomain. Binding of the cytokine IL-6 to the soluble IL-6R (sIL-6R) results in an agonistic IL-6/sIL-6R complex, which activates cells via gp130 irrespective ...
Steffen Riethmueller, J. C. Ehlers, J. Lokau, Stefan Düsterhöft, Katharina Knittler, Gregor Dombrowsky, J. Grötzinger, Björn Rabe, S. Rose-John, Christoph Garbers   +9 more
semanticscholar   +1 more source