Results 81 to 90 of about 4,008,604 (402)

Interleukin-17 in human inflammatory diseases [PDF]

Advances in Dermatology and Allergology, 2014
Human Th17 pro-inflammatory cells are currently defined as cells that produce IL-17A and F, tumor necrosis factor (TNF)-α, IL-6, IL-21, IL-22 and IL-23. Recently discovered related molecules are forming a family of cytokines, the IL-17 family, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F.
Ebrahim Fattahi, Fatemeh Shahneh, Arezoo Gowhari Shabgah   +2 more
openaire   +3 more sources

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, Volume 599, Issue 7, Page 927-951, April 2025.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source

The role of IL10 and IL17 gene polymorphisms in treatment response in children and adolescents with severe asthma [PDF]

Jornal Brasileiro de Pneumologia
Objective: To determine whether polymorphisms of the IL10 and IL17 genes are associated with severe asthma control and bronchodilator reversibility in children and adolescents with severe asthma.
Mariana Isadora Ribeiro Vieira, Mônica Versiani Nunes Pinheiro de Queiroz, Maria Borges Rabelo de Santana, Hatilla dos Santos Silva, Almirane Oliveira, Camila Alexandrina Viana Figueiredo, Eduardo Martín Tarazona Santos, Ryan dos Santos Costa, Laura Maria de Lima Belizário Facury Lasmar   +8 more
doaj   +1 more source

Liposomic lubricants suppress shear-stress induced inflammatory gene regulation in the joint in vivo [PDF]

arXiv, 2023
Osteoarthritis (OA) is a widespread, debilitating joint disease associated with articular cartilage degradation. It is driven via mechano-inflammatory catabolic pathways, presumed up-regulated due to increased shear stress on the cartilage-embedded chondrocytes, that lead to tissue degeneration.
arxiv  

Arthritis Is Developed in Borrelia-Primed And -Infected Mice Deficient of Interleukin-17 [PDF]

, 2016
Interleukin-17 (IL-17) has been shown to participate in the development of Lyme arthritis in experimental mice. For example, neutralization of IL-17 with antibodies inhibits induction of arthritis in Borrelia-primed and -infected C57BL/6 wild-type mice ...
Kuo, Joseph, Munson, Erik, Nardelli, Dean T., Schell, Ronald F., Warner, Thomas F.   +4 more
core   +1 more source

CCR2⁺CD103⁻ intestinal dendritic cells develop from DC-committed precursors and induce interleukin-17 production by T cells [PDF]

, 2014
The identification of intestinal macrophages (m phi s) and dendritic cells (DCs) is a matter of intense debate. Although CD103(+) mononuclear phagocytes (MPs) appear to be genuine DCs, the nature and origins of CD103(-) MPs remain controversial.
Agace, WW, Bain, CC, Guilliams, Martin, Kotarsky, K, Lambrecht, Bart, Luda, K, Milling, SWF, Mowat, AM, Persson, Emma, Scott, Charlotte, Sichien, Dorine, Wright, PB   +11 more
core   +3 more sources

Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation

Science immunology, 2019
Interleukin-17 receptor D serves as a functional receptor for Interleukin-17A in psoriasis-like skin inflammation. A new receptor for interleukin-17 The cytokines interleukin-17A (IL-17A) and IL-17F drive immune activation by binding to the IL-17 ...
Yang Su, Jinling Huang, Xiaohong Zhao, Huiping Lu, Wang Wang, Xuexian O. Yang, Yuling Shi, Xiaohu Wang, Y. Lai, C. Dong   +9 more
semanticscholar   +1 more source

Interleukin 17-A inhibition in the treatment of psoriasis [PDF]

Expert Review of Clinical Immunology, 2015
Interleukin (IL) 17-A appears to be integral to the pathogenesis of chronic plaque psoriasis. Recent clinical trials have shown that blockade of this cytokine with the biologic therapies--secukinumab, ixekizumab and brodalumab--have led to unprecedented treatment efficacy for psoriasis.
Yiu, Zenas Zn, Griffiths, Christopher Em
openaire   +3 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Uric Acid Potential Role in Systemic Inflammation and Negative Symptoms After Acute Antipsychotic Treatment in Schizophrenia

Frontiers in Psychiatry, 2022
Uric acid (UA) has been shown to have neuroprotective or neurotoxic properties, in relation to specific tissues and diseases that have been studied. Previous studies provided contradictory results on the role of UA in schizophrenia as a neurodegenerative
Milica M. Borovcanin, Slavica Minic Janicijevic, Natasa R. Mijailovic, Ivan P. Jovanovic, Nebojsa N. Arsenijevic, Katarina Vesic   +5 more
doaj   +1 more source