Results 1 to 10 of about 78,083 (294)

Association of C-Reactive Protein, Interleukin-1 Receptor Antagonist and Adiponectin with the Metabolic Syndrome [PDF]

Mediators of Inflammation, 2007
This Finnish population-based study, mean age 46 years, evaluates the association of high-sensitivity C-reactive protein (hs-CRP), interleukin-1 receptor antagonist (IL-1Ra), and adiponectin with the NCEP and IDF definitions of metabolic syndrome (MetS). Adiponectin levels were higher, hs-CRP and IL-1Ra levels lower in subjects without MetS compared to
Esko Kumpusalo, Hannu Kautiainen, Mauno Vanhala, Juha Saltevo, Markku Laakso   +4 more
doaj   +4 more sources

G-protein-coupled estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: implications for neuronal self-defense [PDF]

Journal of Neuroinflammation, 2020
Background G-protein-coupled estrogen receptor (GPER/GPR30) is a novel membrane-associated estrogen receptor that can induce rapid kinase signaling in various cells.
Ning Bai, Quanguang Zhang, Wenli Zhang, Bin Liu, Fang Yang, Darrell Brann, Ruimin Wang   +6 more
doaj   +4 more sources

Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein. [PDF]

Journal of Clinical Investigation, 1997
Interleukin 1 receptor antagonist (IL-1Ra) levels are elevated in the blood of patients with a variety of infectious, immune, or traumatic conditions. To examine whether IL1Ra is produced by liver cells with characteristics resembling an acute-phase protein, human primary hepatocytes isolated from liver biopsies and HepG2 hepatoma cells were stimulated
Cem Gabay, Michael F. Smith, Denise M. Eidlen, William P. Arend   +3 more
openalex   +3 more sources

An interleukin-1 receptor antagonist protein protects insulin-producing Beta cells against suppressive effects of interleukin-1? [PDF]

Diabetologia, 1991
The cytokine interleukin-1 beta may have an important role in the autoimmune mediated damage of pancreatic Beta cells in insulin-dependent diabetes mellitus. In the present study we have investigated the effects of an interleukin-1 receptor antagonist protein, a blocker of the type I interleukin-1 receptor, on the suppressive actions of recombinant ...
Décio L. Eizirik, Daniel E. Tracey, Klaus Bendtzen, S. Sandler   +3 more
openalex   +4 more sources

Live Borrelia burgdorferi preferentially activate interleukin-1 beta gene expression and protein synthesis over the interleukin-1 receptor antagonist. [PDF]

Journal of Clinical Investigation, 1992
Lyme arthritis is one of the few forms of chronic arthritis in which the cause is known with certainty. Because cytokines are thought to contribute to the pathogenesis of chronic arthritis, we investigated the effect of the Lyme disease spirochete, Borrelia burgdorferi, on the gene expression and synthesis of IL-1 beta and the IL-1 receptor antagonist (
Laurie C. Miller, Sana Isa, Edouard Vannier, K. Georgilis, Allen C. Steere, C A Dinarello   +5 more
openalex   +3 more sources

Radiolabeling with fluorine-18 of a protein, interleukin-1 receptor antagonist [PDF]

Applied Radiation and Isotopes, 2010
IL-1RA is a naturally occurring antagonist of the pro-inflammatory cytokine interleukin-1 (IL-1) with high therapeutic promise, but its pharmacokinetic remains poorly documented. In this report, we describe the radiolabeling of recombinant human interleukin-1 receptor antagonist (rhIL-1RA) with fluorine-18 to allow pharmacokinetic studies by positron ...
C. Prenant, Christopher Cawthorne, Michael Fairclough, Nancy J. Rothwell, Hervé Boutin   +4 more
openalex   +5 more sources

Counteracting corneal immunoinflammatory lesion with interleukin-1 receptor antagonist protein [PDF]

Journal of Leukocyte Biology, 2004
AbstractHerpetic stromal keratitis (HSK) is a T cell-orchestrated, immunoinflammatory lesion that results from corneal Herpes simplex virus infection. Previous reports indicate an essential role for proinflammatory cytokine interleukin (IL)-1 in HSK pathogenesis.
Partha S. Biswas, Kaustuv Banerjee, Mei Zheng, Barry T. Rouse   +3 more
openalex   +3 more sources

Structural and dynamic properties of IL1 receptors [PDF]

Frontiers in Immunology
The study of the structural and dynamic properties of multidomain proteins is of great interest as they constitute one of the main regulatory mechanisms in the ligand–receptor system.
J. V. Zhukova, J. A. Lopatnikova, S. V. Sennikov   +2 more
doaj   +2 more sources

A method to induce Interleukin-1 Receptor Antagonist Protein from autologous whole blood

Cytokine, 2016
Current orthopedic therapies, aimed solely at symptomatic control, are unable to restore the cytokine imbalance that produces the hallmark clinical profile of osteoarthritis. While a myriad of chemical factors in the cytokine network stimulate local joint inflammation and pain, Interleukin 1 (IL-1) is widely recognized as a key offender and a potential
Angelique Barreto, Timothy R. Braun
openalex   +3 more sources

Mature tau pathology is not improved by interfering with interleukin-1 receptor signaling in two mouse models of tauopathy. [PDF]

PLoS ONE
Prior work suggests that the cytokine interleukin-1β (IL-1β) may be a key regulator of tau pathology in the presence of amyloidosis. Here, we tested the possible benefits of interleukin-1 receptor antagonist (IL-1RA) gene therapy in two mouse models of ...
Dylan J Finneran, Brianna M Jackman, Taylor Desjarlais, Alayna Henry, Ahlam S Soliman, Patricia C Muskus, Rama Shankar, Bin Chen, Kevin R Nash, Dave Morgan, Marcia N Gordon   +10 more
doaj   +2 more sources