G-protein-coupled estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: implications for neuronal self-defense [PDF]
Journal of Neuroinflammation, 2020 Background G-protein-coupled estrogen receptor (GPER/GPR30) is a novel membrane-associated estrogen receptor that can induce rapid kinase signaling in various cells.
Ning Bai +6 more
doaj +5 more sources
Perifollicular transgenic expression of human interleukin-1 receptor antagonist protein following topical application of novel liposome-plasmid DNA formulations in vivo. [PDF]
Journal of Pharmacy and Science, 1997 Expression plasmid DNA for the human interleukin-1 receptor antagonist (IL-1ra) protein was formulated with nonionic:cationic (NC) liposomes or phosphatidylcholine:cationic (PC) liposomes and applied to the auricular skin of hamsters in single- and ...
S. Niemiec +4 more
semanticscholar +3 more sources
Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1993 Gene therapy offers a radical different approach to the treatment of arthritis. Here we have demonstrated that two marker genes (lacZ and neo) and cDNA coding for a potentially therapeutic protein (human interleukin 1-receptor-antagonist protein; IRAP or
G. Bandara +9 more
semanticscholar +2 more sources
Regulatory effects of endogenous interleukin-1 receptor antagonist protein in immunoglobulin G immune complex-induced lung injury. [PDF]
Journal of Clinical Investigation, 1996 IL-1 receptor antagonist (IL-1Ra) has regulatory effects on IL-1 activity both in vitro and in vivo. In the IgG immune complex model of lung injury in rats, exogenously administered human IL-1Ra suppressed neutrophil recruitment and ensuing lung injury ...
Thomas P. Shanley +5 more
semanticscholar +2 more sources
The Turkish Journal of Pediatrics, 2018 Autoinflammatory diseases can cause severe inflammation in bone and skin such as neonatal-onset multisystem inflammatory disease (NOMID), Majeed syndrome, interleukin-36 receptor antagonist deficiency (DITRA) and deficiency of interleukin-1 (IL-1 ...
Betül Sözeri +4 more
doaj +2 more sources
Bone & Joint Research, 2019 Objectives Previously, we reported the improved transfection efficiency of a plasmid DNA-chitosan (pDNA-CS) complex using a phosphorylatable nuclear localization signal-linked nucleic kinase substrate short peptide (pNNS) conjugated to chitosan (pNNS-CS).
Ronglan Zhao +5 more
semanticscholar +2 more sources
Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice. [PDF]
Journal of Clinical Investigation, 1994 To investigate the contribution of IL-1, IL-6, and TNF to the increased osteoclastogenesis induced by estrogen deficiency, ovariectomized (ovx) mice were treated with either IL-1 receptor antagonist (IL-1ra), a competitive inhibitor of IL-1, TNF binding ...
R. Kitazawa +4 more
semanticscholar +2 more sources
An interleukin-1 receptor antagonist protein protects insulin-producing Beta cells against suppressive effects of interleukin-1β [PDF]
Diabetologia, 1991 D. Eizirik +3 more
semanticscholar +2 more sources
Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein. [PDF]
Journal of Clinical Investigation, 1997 Interleukin 1 receptor antagonist (IL-1Ra) levels are elevated in the blood of patients with a variety of infectious, immune, or traumatic conditions.
Cem Gabay +3 more
semanticscholar +2 more sources