Results 11 to 20 of about 148,083 (310)

Structural and dynamic properties of IL1 receptors [PDF]

Frontiers in Immunology
The study of the structural and dynamic properties of multidomain proteins is of great interest as they constitute one of the main regulatory mechanisms in the ligand–receptor system.
J. V. Zhukova, J. A. Lopatnikova, S. V. Sennikov   +2 more
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Association of C-Reactive Protein, Interleukin-1 Receptor Antagonist and Adiponectin with the Metabolic Syndrome

Mediators of Inflammation, 2007
This Finnish population-based study, mean age 46 years, evaluates the association of high-sensitivity C-reactive protein (hs-CRP), interleukin-1 receptor antagonist (IL-1Ra), and adiponectin with the NCEP and IDF definitions of metabolic syndrome (MetS). Adiponectin levels were higher, hs-CRP and IL-1Ra levels lower in subjects without MetS compared to
Esko Kumpusalo, Hannu Kautiainen, Mauno Vanhala, Juha Saltevo, Markku Laakso   +4 more
doaj   +3 more sources

Interleukin-1 in Febrile Infection-Related Epilepsy Syndrome [PDF]

Annals of Child Neurology, 2023
Febrile infection-related epilepsy syndrome (FIRES) characteristically affects previously healthy children, who experience a sudden and explosive onset of super-refractory status epilepticus preceded by febrile infection and accompanied by fulminant ...
Joon Won Kang, Sookyong Koh
doaj   +1 more source

Cardiovascular disease-linked plasma proteins are mainly associated with lung volume

ERJ Open Research, 2023
Background Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been ...
Andreas Rydell, Elisabet Nerpin, XingWu Zhou, Lars Lind, Eva Lindberg, Jenny Theorell Haglöw, Tove Fall, Christer Janson, Karin Lisspers, Sölve Elmståhl, Suneela Zaigham, Olle Melander, Peter M. Nilsson, Johan Ärnlöv, Andrei Malinovschi   +14 more
doaj   +1 more source

Solution structure of human interleukin‐1 receptor antagonist protein [PDF]

FEBS Letters, 1994
Interleukin‐1 receptor antagonist protein (IRAP) is a naturally occurring inhibitor of the interleukin‐1 receptor. In contrast to IL‐1β IRAP binds to the IL‐1 receptor but does not elicit a physiological response. We have determined the solution structure of IRAP using NMR spectroscopy.
Stockman, Brian J., Scahill, Terrence A., Strakalaitis, Nancy A., Brunner, David P., Yem, Anthony W., Deibel, Martin R.   +5 more
openaire   +2 more sources

Clinical and Functional Results Using Autologous Conditioned Serum in the Treatment of Acute Ankle Injuries in Sporting Activities

Journal of Orthopedic and Spine Trauma, 2022
Background: Ankle ligament injuries in the sports like basketball, volleyball, and cricket are the most common reasons for missed participation in athletics, accounting for 14% of all sports injuries.
Satya Kumar Koduru, Balakrishhna Bathina, Manidhar Sane   +2 more
doaj   +1 more source

IL-1Ra Protects Hepatocytes from CCl4-Induced Hepatocellular Apoptosis via Activating the ERK1/2 Pathway

Pharmaceutical Fronts, 2020
Interleukin-1 receptor antagonist is an important acute-phase protein and an immune mediator, and its expression is associated with the development of hepatitis or acute liver failure.
Ying Zheng, Xinyi Xiao, Zhuoyi Yang, Meiqi Zhou, Hui Chen, Siyi Bai, Jianwei Zhu, Yunsheng Yuan   +7 more
doaj   +1 more source

Radiolabeling with fluorine-18 of a protein, interleukin-1 receptor antagonist [PDF]

Applied Radiation and Isotopes, 2010
IL-1RA is a naturally occurring antagonist of the pro-inflammatory cytokine interleukin-1 (IL-1) with high therapeutic promise, but its pharmacokinetic remains poorly documented. In this report, we describe the radiolabeling of recombinant human interleukin-1 receptor antagonist (rhIL-1RA) with fluorine-18 to allow pharmacokinetic studies by positron ...
Prenant, C., Cawthorne, C., Fairclough, M., Rothwell, N., Boutin, H.   +4 more
openaire   +4 more sources

Blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in patients with symptoms suggesting reactive hypoglycemia [PDF]

Brazilian Journal of Medical and Biological Research, 2016
We evaluated the impact of postprandial glycemia on blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in non-diabetic patients with symptoms suggesting reactive hypoglycemia.
W. Eik Filho, S.S. Marcon, T. Krupek, I.T.S. Previdelli, O.C.N. Pereira, M.A.R.C.P. Silva, R.B. Bazotte   +6 more
doaj   +3 more sources

Defining Potential Therapeutic Targets in Coronavirus Disease 2019: A Cross-Sectional Analysis of a Single-Center Cohort

Critical Care Explorations, 2021
OBJECTIVES:. Multiple mechanisms have been proposed to explain disease severity in coronavirus disease 2019. Therapeutic approaches need to be underpinned by sound biological rationale. We evaluated whether serum levels of a range of proposed coronavirus
Nishkantha Arulkumaran, PhD, Timothy Arthur Chandos Snow, FFICM, Adarsh Kulkarni, MD, David Brealey, PhD, Hannah Rickman, MB BChir, Chloe Rees-Spear, MSc, Moira J. Spyer, PhD, Judith Heaney, PhD, Edmund Garr, PhD, Bryan Williams, PhD, Peter Cherepanov, PhD, George Kassiotis, PhD, Michael Lunn, PhD, Catherine Houlihan, PhD, Laura E. McCoy, PhD, Eleni Nastouli, FRCPath, Mervyn Singer, FRCP   +16 more
doaj   +1 more source