Counteracting corneal immunoinflammatory lesion with interleukin‐1 receptor antagonist protein [PDF]
Journal of Leukocyte Biology, 2004 AbstractHerpetic stromal keratitis (HSK) is a T cell-orchestrated, immunoinflammatory lesion that results from corneal Herpes simplex virus infection. Previous reports indicate an essential role for proinflammatory cytokine interleukin (IL)-1 in HSK pathogenesis.
P. Biswas +3 more
semanticscholar +5 more sources
Association of C-Reactive Protein, Interleukin-1 Receptor Antagonist and Adiponectin with the Metabolic Syndrome [PDF]
Mediators of Inflammation, 2007 This Finnish population-based study, mean age 46 years, evaluates the association of high-sensitivity C-reactive protein (hs-CRP), interleukin-1 receptor antagonist (IL-1Ra), and adiponectin with the NCEP and IDF definitions of metabolic syndrome (MetS). Adiponectin levels were higher, hs-CRP and IL-1Ra levels lower in subjects without MetS compared to
Esko Kumpusalo +4 more
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Structure studies of recombinant interleukin-1 receptor antagonist protein [PDF]
Acta Crystallographica Section A Foundations of Crystallography, 1993 Howard Einspahr +4 more
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Accelerated Achilles tendon healing with interleukin-1 receptor antagonist protein in rabbits
TURKISH JOURNAL OF VETERINARY AND ANIMAL SCIENCES, 2017 e current study describes the use of interleukin-1 receptor antagonist protein (IL-1Ra) as a possible strategy for optimizing tendon healing and repair by presenting histologically visible changes in rabbit Achilles tendon tissue a er longitudinal tenotomy. e study was carried out on 26 Californian rabbits divided into two equal groups.
Marko Pećin +6 more
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Circulation, 1998 BACKGROUND The cytokines interleukin 1 (IL-1) and tumor necrosis factor (TNF) are secreted by the different cell populations of the vascular wall and have been suggested to promote atherosclerosis.
R. Elhage +5 more
semanticscholar +2 more sources
Interleukin-1 Receptor Antagonist, Interleukin-6, and C-Reactive Protein as Predictors of Mortality in Nonagenarians: The Vitality 90+ Study [PDF]
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2007 Inflammation plays a major role in both aging and chronic disease. Longitudinal studies in very old people can improve our understanding of these processes. We investigated blood levels of C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1ra), and their combinations as predictors of mortality in nonagenarians.This ...
Marja Jylhä +6 more
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Live Borrelia burgdorferi preferentially activate interleukin-1 beta gene expression and protein synthesis over the interleukin-1 receptor antagonist. [PDF]
Journal of Clinical Investigation, 1992 Lyme arthritis is one of the few forms of chronic arthritis in which the cause is known with certainty. Because cytokines are thought to contribute to the pathogenesis of chronic arthritis, we investigated the effect of the Lyme disease spirochete, Borrelia burgdorferi, on the gene expression and synthesis of IL-1 beta and the IL-1 receptor antagonist (
Laurie C. Miller +5 more
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Interleukin-1 in Febrile Infection-Related Epilepsy Syndrome [PDF]
Annals of Child Neurology, 2023 Febrile infection-related epilepsy syndrome (FIRES) characteristically affects previously healthy children, who experience a sudden and explosive onset of super-refractory status epilepticus preceded by febrile infection and accompanied by fulminant ...
Joon Won Kang, Sookyong Koh
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Interleukin-1 receptor antagonist: a "novel" acute phase protein with antiinflammatory activities. [PDF]
Journal of Clinical Investigation, 1997 Fabio Cominelli, Theresa T. Pizarro
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A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer [PDF]
Arthritis Res Ther, 2003 Anakinra, the recombinant form of IL-1 receptor antagonist (IL-1Ra), has been approved for clinical use in the treatment of rheumatoid arthritis as the drug Kineret trade mark, but it must be administered daily by subcutaneous injection. Gene transfer may offer a more effective means of delivery.
Jean-Noël Gouze +9 more
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