Interleukin-1 Receptor Antagonist, Interleukin-6, and C-Reactive Protein as Predictors of Mortality in Nonagenarians: The Vitality 90+ Study [PDF]
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2007 Inflammation plays a major role in both aging and chronic disease. Longitudinal studies in very old people can improve our understanding of these processes. We investigated blood levels of C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1ra), and their combinations as predictors of mortality in nonagenarians.This ...
Marja Jylhä +6 more
openalex +3 more sources
Accelerated Achilles tendon healing with interleukin-1 receptor antagonist protein in rabbits
TURKISH JOURNAL OF VETERINARY AND ANIMAL SCIENCES, 2017 e current study describes the use of interleukin-1 receptor antagonist protein (IL-1Ra) as a possible strategy for optimizing tendon healing and repair by presenting histologically visible changes in rabbit Achilles tendon tissue a er longitudinal tenotomy. e study was carried out on 26 Californian rabbits divided into two equal groups.
Marko Pećin +6 more
openalex +3 more sources
Dual biological functions of an interleukin‐1 receptor antagonist–interleukin‐10 fusion protein and its suppressive effects on joint inflammation [PDF]
Immunology, 2004 SummaryThe aim of this study was to construct and purify a novel interleukin‐1 receptor antagonist (IL‐1ra)–interleukin‐10 (IL‐10) fusion protein and determine its biological function and anti‐inflammatory effects. The isolated cDNAs of two inhibitory cytokines (IL‐1ra, IL‐10) were used to construct a cDNA for the IL‐1ra–IL‐10 fusion protein.
Deh‐Ming Chang +7 more
openalex +3 more sources
Cytokine-induced interleukin-1 receptor antagonist protein expression in genetically engineered equine mesenchymal stem cells for osteoarthritis treatment. [PDF]
J Gene Med, 2018 Gabner S +6 more
europepmc +3 more sources
Sustained intra-cartilage delivery of interleukin-1 receptor antagonist using cationic peptide and protein-based carriers [PDF]
Osteoarthritis and Cartilage, 2023 Blocking the interleukin-1 (IL-1) catabolic cascade following joint trauma can be achieved using its receptor antagonist, IL-1Ra. However, its clinical translation for osteoarthritis therapy has been unsuccessful due to its rapid joint clearance and lack of targeting and penetration into deep cartilage layers at therapeutic concentrations.
Shikha Mehta +6 more
openalex +3 more sources
Interleukin-1 receptor antagonist protein (IL-1Ra) and miR-140 overexpression via pNNS-conjugated chitosan-mediated gene transfer enhances the repair of full-thickness cartilage defects in a rabbit model. [PDF]
Bone Joint Res, 2019 Zhao R +5 more
europepmc +3 more sources
Interleukin-1 Receptor Antagonist Protein [PDF]
, 2020 National Cancer Institute
openalex +2 more sources
Journal of Biological Chemistry, 1990 Culture medium conditioned by phorbol 12-myristate 13-acetate-differentiated THP-1 cells contained interleukin 1 (IL-1) antagonist activity as measured by inhibition of both IL-1 beta binding to receptors on YT cells and inhibition of IL-1/phytohemagglutinin-stimulated IL-2 synthesis by LBRM-33-1A5 T cells. Based on their ability to compete for 125I-IL-
Michał Bieńkowski +9 more
openalex +3 more sources
Interleukin-1 receptor antagonist: a "novel" acute phase protein with antiinflammatory activities. [PDF]
Journal of Clinical Investigation, 1997 Fabio Cominelli, Theresa T. Pizarro
openalex +2 more sources
Structure studies of recombinant interleukin-1 receptor antagonist protein [PDF]
Acta Crystallographica Section A Foundations of Crystallography, 1993 Howard Einspahr +4 more
openalex +3 more sources