Results 31 to 40 of about 628,146 (183)
Adenoviral overexpression of interleukin-1 receptor antagonist protein increases β-cell replication in rat pancreatic islets [PDF]
Gene Therapy, 2005 The naturally occurring inhibitor of interleukin-1 (IL-1) action, interleukin-1 receptor antagonist protein (IRAP), binds to the type 1 IL-1 receptor but does not initiate IL-1 signal transduction. In this study, we have determined the effects of IL-1beta and IRAP overexpression on adult beta-cell replication and viability.
N. Téllez +5 more
semanticscholar +4 more sources
A method to induce Interleukin-1 Receptor Antagonist Protein from autologous whole blood
Cytokine, 2016 Current orthopedic therapies, aimed solely at symptomatic control, are unable to restore the cytokine imbalance that produces the hallmark clinical profile of osteoarthritis. While a myriad of chemical factors in the cytokine network stimulate local joint inflammation and pain, Interleukin 1 (IL-1) is widely recognized as a key offender and a potential
Angelique Barreto, Timothy R. Braun
openalex +4 more sources
Orthopedic Reviews, 2013 The purpose of the present study was to investigate the effect of intra-articular injections of autologous conditioned serum on human hip osteoarthritis and to test whether a potential treatment effect might be increased by additional injections of ...
Axel W.A. Baltzer +4 more
doaj +1 more source
مجله دانشکده پزشکی اصفهان, 2019 Background: Recombinant human interleukin-1 receptor antagonist (IL-1RA) is a protein with 153 amino acids and molecular weight of 16.83 kDa. This drug protein is known as Anakinra, and has an effective application in the treatment of rheumatoid ...
Hanieh Fardgoli +2 more
doaj +1 more source
The interleukin-1 receptor antagonist influences interleukin-1 effects in rat and mouse
Mediators of Inflammation, 1992 In this work we have focused on the ability of interleukin-1 to induce an acute phase protein response and a degranulation of polymorphonuclear leukocytes in vivo.
P. Bjrök, K. Ohlsson
doaj +1 more source
Health Science Reports, 2023 Background and Aims Major depressive disorder (MDD) is characterized by the occurrence of one or more depressive episodes lasting a minimum of 2 weeks and is marked by a persistently low mood and a lack of enjoyment in daily activities.
Zabun Nahar +3 more
doaj +1 more source
Effects of mesoporous SiO2-CaO nanospheres on the murine peritoneal macrophages -- Candida albicans interface [PDF]
Int Immunopharmacol International Immunopharmacology. 2021 Mar
20;94:107457, 2021 The use of nanoparticles for intracellular drug delivery could reduce the toxicity and side effects of the drug but, the uptake of these nanocarriers could induce adverse effects on cells and tissues after their incorporation. Macrophages play a central role in host defense and are responsible for in vivo nanoparticle trafficking.
arxiv +1 more source
Arthritis & Rheumatism, 1997 OBJECTIVE To determine the efficacy of local human interleukin-1 receptor antagonist (HuIL-1Ra) gene therapy in murine collagen-induced arthritis (CIA). METHODS DBA/1 mice were immunized against bovine type II collagen.
A. C. Bakker +4 more
semanticscholar +1 more source
Frontiers in Medicine, 2017 Recurrent pericarditis is a common complication of acute pericarditis (15–30%) for which, in most cases, no underlying etiology is found [idiopathic recurrent pericarditis (IRP)]. IRP is currently viewed as an autoinflammatory disease with characteristic
George Lazaros +2 more
doaj +1 more source
Changes in haematological indices following local application of interleukin-1 receptor antagonist protein after tenotomy in rabbits [PDF]
Acta Veterinaria Brno, 2017 Interleukin-1 (IL-1) is the most important cytokine in the inflammation cascade activation in all tissues and is present in acute and chronic phases of inflammation. By blocking IL-1 binding to target cells, numerous inflammation processes are prevented.
Marko Pećin +5 more
openalex +4 more sources