Results 41 to 50 of about 628,146 (183)

Soluble interleukin‐1 receptor accessory protein ameliorates collagen‐induced arthritis by a different mode of action from that of interleukin‐1 receptor antagonist [PDF]

Arthritis & Rheumatism, 2005
AbstractObjectiveTo discern the mode of interleukin‐1 (IL‐1) inhibition of soluble IL‐1 receptor accessory protein (sIL‐1RAcP) by comparison with IL‐1 receptor antagonist (IL‐1Ra) in arthritis.MethodsAdenoviral vectors encoding either sIL‐1RAcP or IL‐1Ra were administered systemically before onset of collagen‐induced arthritis in DBA/1 mice.
Smeets, R.L.L., Joosten, L.A.B., Arntz, O.J., Bennink, M.B., Takahashi, N., Carlsen, H., Martin, M.U., Berg, W.B. van den, Loo, F.A.J. van de   +8 more
openaire   +4 more sources

Helicobacter pylori Seropositivity in Patients with Interleukin-1 Polymorphisms Is Significantly Associated with ST-Segment Elevation Myocardial Infarction. [PDF]

PLoS ONE, 2016
Helicobacter pylori infection and interleukin-1 polymorphisms are associated with an increased risk of gastric cancer. We examined the prevalence of Helicobacter pylori seropositivity and interleukin-1 polymorphisms between ST-segment elevation ...
Noriaki Tabata, Daisuke Sueta, Tomonori Akasaka, Yuichiro Arima, Kenji Sakamoto, Eiichiro Yamamoto, Yasuhiro Izumiya, Megumi Yamamuro, Kenichi Tsujita, Sunao Kojima, Koichi Kaikita, Kazunori Morita, Kentaro Oniki, Junji Saruwatari, Kazuko Nakagawa, Seiji Hokimoto   +15 more
doaj   +1 more source

Intravenous transplantation of olfactory ensheathing cells reduces neuroinflammation after spinal cord injury via interleukin-1 receptor antagonist

Theranostics, 2021
Rationale: Olfactory ensheathing cell (OEC) transplantation has emerged as a promising therapy for spinal cord injury (SCI) repair. In the present study, we explored the possible mechanisms of OECs transplantation underlying neuroinflammation modulation.
Lijian Zhang, Xiaoqing Zhuang, Päivi Kotitalo, T. Keller, A. Krzyczmonik, M. Haaparanta-Solin, O. Solin, S. Forsback, T. Grönroos, Chunlei Han, F. López-Picón, Hechun Xia   +11 more
semanticscholar   +1 more source

The experimental treatment of corneal graft rejection with the interleukin-1 receptor antagonist (IL-1ra) gene. [PDF]

PLoS ONE, 2013
PURPOSE: To investigate the protective effects of interleukin-1 receptor antagonist (IL-1ra) gene transfer in a rat model of corneal graft rejection.
Jin Yuan, Yi Liu, Weilan Huang, Shiyou Zhou, Shiqi Ling, Jiaqi Chen   +5 more
doaj   +1 more source

Identification of Suitable Drug Combinations for Treating COVID-19 Using a Novel Machine Learning Approach: The RAIN Method

Life, 2022
COVID-19 affects several human genes, each with its own p-value. The combination of drugs associated with these genes with small p-values may lead to an estimation of the combined p-value between COVID-19 and some drug combinations, thereby increasing ...
Aliakbar Kiaei, Nader Salari, Mahnaz Boush, Kamran Mansouri, Amin Hosseinian-Far, Hooman Ghasemi, Masoud Mohammadi   +6 more
doaj   +1 more source

Host genome polymorphisms and tuberculosis infection: What we have to say?

Egyptian Journal of Chest Disease and Tuberculosis, 2014
Several epidemiology studies suggest that host genetic factors play important roles in susceptibility, protection and progression of tuberculosis infection.
Said Alfin Khalilullah, Harapan Harapan, Nabeeh A. Hasan, Wira Winardi, Ichsan Ichsan, Mulyadi Mulyadi   +5 more
doaj   +1 more source

The Clinical Significance of Interleukin-1 Receptor Antagonist +2018 Polymorphism in Rheumatoid Arthritis. [PDF]

PLoS ONE, 2016
Interleukin-1 receptor antagonist (IL-1Ra) acts as an inhibitor of IL-1; which is one of the culprit cytokines in rheumatoid arthritis (RA). Although +2018 polymorphism of IL-1Ra has been implicated in the pathogenesis of RA, its importance remains ...
Endom Ismail, Omimah Khaled Jaber Nofal, Rajalingham Sakthiswary, Syahrul Sazliyana Shaharir, Radhika Sridharan   +4 more
doaj   +1 more source

Expression profiles of TRPV1, TRPV4, TLR4 and ERK1/2 in the dorsal root ganglionic neurons of a cancer-induced neuropathy rat model [PDF]

Maqboul A, Elsadek B. (2018) Expression profiles of TRPV1, TRPV4, TLR4 and ERK1/2 in the dorsal root ganglionic neurons of a cancer-induced neuropathy rat model. PeerJ 6:e4622 https://doi.org/10.7717/peerj.4622, 2018
Background: The spread of tumors through neural routes is common in several types of cancer in which patients suffer from a moderate-to-severe neuropathy, neural damage and a distorted quality of life. Here we aim to examine the expression profiles of transient receptor potential vanilloid 1 (TRPV1) and of transient receptor potential vanilloid 4 ...
arxiv   +1 more source

Genetic Variation in Toll-Interacting Protein Is Associated With Leprosy Susceptibility and Cutaneous Expression of Interleukin 1 Receptor Antagonist [PDF]

Journal of Infectious Diseases, 2015
Leprosy is a chronic disease characterized by skin and peripheral nerve pathology and immune responses that fail to control Mycobacterium leprae. Toll-interacting protein (TOLLIP) regulates Toll-like receptor (TLR) and interleukin 1 receptor (IL-1R) signaling against mycobacteria. We analyzed messenger RNA (mRNA) expression of candidate immune genes in
Javeed A. Shah, William R. Berrington, Jay C. Vary, Richard D. Wells, Glenna J. Peterson, Chhatra B. Kunwar, Saraswoti Khadge, Deanna A. Hagge, Thomas R. Hawn   +8 more
openalex   +3 more sources

Investigation of the effect of Interleukin-1 receptor antagonist (IL-1ra) on markers of inflammation in non-ST elevation acute coronary syndromes (The MRC-ILA-HEART Study)

Trials, 2008
Background Acute Coronary Syndromes account for 15% of deaths in the UK, and patients remain at significant risk of re-admission for future complications and death.
Flather Marcus D, Lucking Andrew J, Fox Keith AA, Hall Alistair S, Greenwood John P, Gunn Julian P, Morton Allison C, Crossman David C, Lees Belinda, Foley Claire E   +9 more
doaj   +1 more source