Results 41 to 50 of about 78,083 (294)

Host genome polymorphisms and tuberculosis infection: What we have to say?

Egyptian Journal of Chest Disease and Tuberculosis, 2014
Several epidemiology studies suggest that host genetic factors play important roles in susceptibility, protection and progression of tuberculosis infection.
Said Alfin Khalilullah, Harapan Harapan, Nabeeh A. Hasan, Wira Winardi, Ichsan Ichsan, Mulyadi Mulyadi   +5 more
doaj   +1 more source

The experimental treatment of corneal graft rejection with the interleukin-1 receptor antagonist (IL-1ra) gene. [PDF]

PLoS ONE, 2013
PURPOSE: To investigate the protective effects of interleukin-1 receptor antagonist (IL-1ra) gene transfer in a rat model of corneal graft rejection.
Jin Yuan, Yi Liu, Weilan Huang, Shiyou Zhou, Shiqi Ling, Jiaqi Chen   +5 more
doaj   +1 more source

The Clinical Significance of Interleukin-1 Receptor Antagonist +2018 Polymorphism in Rheumatoid Arthritis. [PDF]

PLoS ONE, 2016
Interleukin-1 receptor antagonist (IL-1Ra) acts as an inhibitor of IL-1; which is one of the culprit cytokines in rheumatoid arthritis (RA). Although +2018 polymorphism of IL-1Ra has been implicated in the pathogenesis of RA, its importance remains ...
Endom Ismail, Omimah Khaled Jaber Nofal, Rajalingham Sakthiswary, Syahrul Sazliyana Shaharir, Radhika Sridharan   +4 more
doaj   +1 more source

Investigation of the effect of Interleukin-1 receptor antagonist (IL-1ra) on markers of inflammation in non-ST elevation acute coronary syndromes (The MRC-ILA-HEART Study)

Trials, 2008
Background Acute Coronary Syndromes account for 15% of deaths in the UK, and patients remain at significant risk of re-admission for future complications and death.
Flather Marcus D, Lucking Andrew J, Fox Keith AA, Hall Alistair S, Greenwood John P, Gunn Julian P, Morton Allison C, Crossman David C, Lees Belinda, Foley Claire E   +9 more
doaj   +1 more source

Soluble interleukin‐1 receptor accessory protein ameliorates collagen‐induced arthritis by a different mode of action from that of interleukin‐1 receptor antagonist [PDF]

Arthritis & Rheumatism, 2005
AbstractObjectiveTo discern the mode of interleukin‐1 (IL‐1) inhibition of soluble IL‐1 receptor accessory protein (sIL‐1RAcP) by comparison with IL‐1 receptor antagonist (IL‐1Ra) in arthritis.MethodsAdenoviral vectors encoding either sIL‐1RAcP or IL‐1Ra were administered systemically before onset of collagen‐induced arthritis in DBA/1 mice.
Smeets, R.L.L., Joosten, L.A.B., Arntz, O.J., Bennink, M.B., Takahashi, N., Carlsen, H., Martin, M.U., Berg, W.B. van den, Loo, F.A.J. van de   +8 more
openaire   +3 more sources

Effect of add-on hydroxychloroquine therapy on serum proinflammatory cytokine levels in patients with systemic lupus erythematosus

Scientific Reports, 2022
We investigated the effect of hydroxychloroquine (HCQ) as an add-on treatment to immunosuppressants on the expression of proinflammatory cytokines in patients with systemic lupus erythematosus.
Risa Wakiya, Kiyo Ueeda, Shusaku Nakashima, Hiromi Shimada, Tomohiro Kameda, Mai Mahmoud Fahmy Mansour, Mikiya Kato, Taichi Miyagi, Koichi Sugihara, Mao Mizusaki, Rina Mino, Norimitsu Kadowaki, Hiroaki Dobashi   +12 more
doaj   +1 more source

Effects of IL-38 on Macrophages and Myocardial Ischemic Injury

Frontiers in Immunology, 2022
Macrophages play an important role in clearing necrotic myocardial tissues, myocardial ischemia–reperfusion injury, and ventricular remodeling after myocardial infarction.
Zhiyang Li, Yan Ding, Yudong Peng, Jian Yu, Chengliang Pan, Yifan Cai, Qian Dong, Yucheng Zhong, Ruirui Zhu, Kunwu Yu, Qiutang Zeng   +10 more
doaj   +1 more source

IL-1β-Induced Matrix Metalloprotease-1 Promotes Mesenchymal Stem Cell Migration via PAR1 and G-Protein-Coupled Signaling Pathway

Stem Cells International, 2018
Mesenchymal stem cells (MSCs) are known for homing to sites of injury in response to signals of cellular damage. However, the mechanisms of how cytokines recruit stem cells to target tissue are still unclear.
Ming-Siou Chen, Cheng-Yu Lin, Yun-Hsuan Chiu, Chie-Pein Chen, Pei-Jiun Tsai, Hwai-Shi Wang   +5 more
doaj   +1 more source

Systemic inflammation and protease profile of Afro-Caribbean patients with sepsis

SAGE Open Medicine, 2021
Objectives: Sepsis is one of the leading causes of morbidity and mortality within the healthcare system and remains a diagnostic and therapeutic challenge.
Panid Borhanjoo, Navneet Singh, Sridesh Nath, MD Sadakat Chowdhury, Carl Swanson, Ryan Kaiser, Patrick Geraghty, Robert F Foronjy, Lillian Chow   +8 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source