Results 251 to 260 of about 848,154 (350)

Data from The Interleukin 22 Pathway Interacts with Mutant KRAS to Promote Poor Prognosis in Colon Cancer

, 2023
Sarah McCuaig, David Barras, Elizabeth H. Mann, Matthias Friedrich, Samuel J. Bullers, Alina Janney, Lucy C. Garner, Enric Domingo, Viktor H. Koelzer, Mauro Delorenzi, Sabine Tejpar, Tim Maughan, Nathaniel R. West, Fiona Powrie   +13 more
openalex   +1 more source

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

Commensal bacterial outer membrane protein A induces interleukin-22 production. [PDF]

Cell Rep
Wang Y, Ngo VL, Zou J, Gewirtz AT.
europepmc   +1 more source

Interleukin-22 receptor 1 is expressed in multinucleated giant cells: A study on intestinal tuberculosis and Crohn's disease

, 2019
Ziqi Yu, Wenfei Wang, Youchao Dai, Xinchun Chen, Jianyong Chen   +4 more
openalex   +1 more source

A Mitochondria‐Specific Nanomedicine for Synergistic Chemo‐Photothermal Therapy and Immunogenic Activation Against Breast Cancer

Advanced Science, EarlyView.
Peptide dendrimer–based nanoplatform with mitochondria‐targeting capability was developed for synergistic chemo‐photothermal therapy. The system promotes efficient transcytosis, induces mitochondrial dysfunction, triggers immunogenic cell death (ICD), and enhance antitumor immunity by promoting dendritic cell maturation and T‐cell activation, resulting
Min Li, Jiangqi Feng, Junyang Zhuang, Qingguo Zhong, Yanda Li, Yanzhuo Lv, Shaoteng Huang, Xiangyu Huang, Mingbo Zhang, Xiaofeng Cai, Yuxin Wang, Wenping Chen, Zhenyu Duan, Zhou Chen, Kui Luo, Ning Li   +15 more
wiley   +1 more source

Circulating Interleukin-22 in Patients with Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. [PDF]

J Clin Med
Correia AF, Oliveira CGC, Oliveira DC, Pereira MC, Carvalho FA, Martins ECC, Oliveira DC.   +6 more
europepmc   +1 more source

VEGF-B antibody and interleukin-22 fusion protein ameliorates diabetic nephropathy through inhibiting lipid accumulation and inflammatory responses

, 2020
Yilan Shen, Wei Chen, Lei Han, Qi Bian, Jiajun Fan, Zhonglian Cao, Xin Jin, Tao Ding, Zongshu Xian, Zhiyong Guo, Wei Zhang, Dianwen Ju, Xiaobin Mei   +12 more
openalex   +1 more source

Sertoli Cell‐Derived Extracellular Vesicles Orchestrate Cadmium‐Induced Testicular Inflammation and Fibrosis

Advanced Science, EarlyView.
Environmental cadmium exposure disrupts testicular homeostasis through a novel intercellular communication axis. Stressed Sertoli cells release extracellular vesicles carrying damage‐associated molecular patterns and mitochondrial fragments, which activate macrophages via TLR4/NF‐κB signaling.
Jianfeng Ma, Mailin Gan, Shuang Liang, Siyu Chen, Ziling Hao, Yiting Yang, Jiawei Lu, Qihang Wu, Yuqian Shi, Lijun Sun, Jiaxin Li, Saihao Wang, Yan Wang, Xiaofeng Zhou, Lei Chen, Ye Zhao, Li Zhu, Linyuan Shen   +17 more
wiley   +1 more source

Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis. [PDF]

Nat Commun
Sajiir H, Keshvari S, Wong KY, Borg DJ, Steyn FJ, Fercher C, Taylor K, Taylor B, Barnard RT, Müller A, Moniruzzaman M, Miller G, Wang R, Fotheringham A, Schreiber V, Sheng YH, Hancock JL, Loo D, Burr L, Huynh T, Lockett J, Ramm GA, Macdonald GA, Prins JB, McGuckin MA, Hasnain SZ.   +25 more
europepmc   +1 more source

Serum levels of interleukin‐22 and hepatitis B core‐related antigen are associated with treatment response to entecavir therapy in chronic hepatitis B [PDF]

, 2013
Sadahisa Okuhara, Takeji Umemura, Satoru Joshita, Soichiro Shibata, Takefumi Kimura, Susumu Morita, Michiharu Komatsu, Akihiro Matsumoto, Kaname Yoshizawa, Yoshihiko Katsuyama, Masao Ôta, Eiji Tanaka   +11 more
openalex   +1 more source