Transient juvenile demyelination impairs maturation and function of parvalbumin-positive interneurons in the prefrontal cortex. [PDF]
PLoS BiologyRecent studies have highlighted axonal myelination as a common feature of parvalbumin-positive (PV) interneurons throughout the cerebral cortex. However, the precise function of PV interneuron myelination remains incompletely understood.
Sara Hijazi +3 more
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Prefrontal gamma oscillations and fear extinction learning require early postnatal interneuron-oligodendroglia communication [PDF]
Nature CommunicationsEmerging evidence links oligodendrocyte (OL) lineage cells and myelin to cognitive processes, yet the role of myelination in shaping neuronal networks critical for cognitive tasks remains unknown.
Fabrice Plaisier +6 more
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Spinal interneuron population dynamics underlying flexible pattern generation [PDF]
Nature CommunicationsThe mammalian spinal locomotor network is composed of diverse populations of interneurons that collectively orchestrate and execute a range of locomotor behaviors.
Lahiru N. Wimalasena +2 more
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In-silico EEG biomarkers of reduced inhibition in human cortical microcircuits in depression.
PLoS Computational Biology, 2023 Reduced cortical inhibition by somatostatin-expressing (SST) interneurons has been strongly associated with treatment-resistant depression. However, due to technical limitations it is impossible to establish experimentally in humans whether the effects ...
Frank Mazza +4 more
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Cellular signaling impacts upon GABAergic cortical interneuron development
Frontiers in Neuroscience, 2023 The development and maturation of cortical GABAergic interneurons has been extensively studied, with much focus on nuclear regulation via transcription factors.
Emily Ling-Lin Pai +3 more
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Frontiers in Synaptic Neuroscience, 2022 General anesthetics disrupt brain processes involved in consciousness by altering synaptic patterns of excitation and inhibition. In the cerebral cortex and hippocampus, GABAergic inhibition is largely mediated by inhibitory interneurons, a heterogeneous
Iris A. Speigel +2 more
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eLife, 2020 In vitro work revealed that excitatory synaptic inputs to hippocampal inhibitory interneurons could undergo Hebbian, associative, or non-associative plasticity.
Igor Gridchyn +3 more
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A Novel LHX6 Reporter Cell Line for Tracking Human iPSC-Derived Cortical Interneurons
Cells, 2022 GABAergic interneurons control the neural circuitry and network activity in the brain. The dysfunction of cortical interneurons, especially those derived from the medial ganglionic eminence, contributes to neurological disease states.
Maria Cruz-Santos +2 more
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Genetic impairment of folate metabolism regulates cortical interneurons and social behavior
Frontiers in Neuroscience, 2023 IntroductionThe implications of folate deficiency in neuropsychiatric disorders were demonstrated in numerous studies. Genetic deficiency in a key folate metabolism enzyme, MTHFR, is an example of the interaction between genetic and environmental risk ...
Noa Sadigurschi +5 more
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Contrasting roles of axonal (pyramidal cell) and dendritic (interneuron) electrical coupling in the generation of neuronal network oscillations [PDF]
, 2003 Electrical coupling between pyramidal cell axons, and between interneuron dendrites, have both been described in the hippocampus. What are the functional roles of the two types of coupling?
Bibbig, A. +7 more
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