Results 11 to 20 of about 57,859 (281)

Hippocampal GABAergic Inhibitory Interneurons [PDF]

open access: yesPhysiological Reviews, 2017
In the hippocampus GABAergic local circuit inhibitory interneurons represent only ~10–15% of the total neuronal population; however, their remarkable anatomical and physiological diversity allows them to regulate virtually all aspects of cellular and circuit function. Here we provide an overview of the current state of the field of interneuron research,
Pelkey, Kenneth A.   +5 more
openaire   +4 more sources

Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks

open access: yeseLife, 2016
Interneurons are critical for proper neural network function and can activate Ca2+ signaling in astrocytes. However, the impact of the interneuron-astrocyte signaling into neuronal network operation remains unknown.
Gertrudis Perea   +18 more
doaj   +1 more source

Vascular-derived SPARC and SerpinE1 regulate interneuron tangential migration and accelerate functional maturation of human stem cell-derived interneurons

open access: yeseLife, 2021
Cortical interneurons establish inhibitory microcircuits throughout the neocortex and their dysfunction has been implicated in epilepsy and neuropsychiatric diseases.
Matthieu Genestine   +14 more
doaj   +1 more source

New insights into the classification and nomenclature of cortical GABAergic interneurons. [PDF]

open access: yes, 2013
A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxonomical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web ...
A Karagiannis   +82 more
core   +2 more sources

Application of cluster analysis in morphological characteristics of neurons

open access: yes浙江大学学报. 农业与生命科学版, 2011
Base on the data for three dimensional (3D) coordinate of 49 neurons, 16 morphological parameters were obtained by calculation. According to the factor analysis of the morphological parameters, three major characteristics, including dimension, degree of ...
ZHANG Jing   +5 more
doaj   +1 more source

Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types. [PDF]

open access: yes, 2017
Many subtypes of cortical interneurons (CINs) are found in adult mouse cortices, but the mechanism generating their diversity remains elusive. We performed single-cell RNA sequencing on the mouse embryonic medial ganglionic eminence (MGE), the major ...
Chen, Ying-Jiun J   +7 more
core   +1 more source

Modeling interneuron-specific (IS) interneurons in hippocampus [PDF]

open access: yesBMC Neuroscience, 2014
The hippocampus and cortex have a large diversity in inhibitory interneuron types. These local interneurons exert inhibitory control over neuronal populations in the hippocampus [1]. Although much is known about how hippocampal inhibitory interneurons exert control over pyramidal cells and synchronize local network activity, less is known about how the
Guet-McCreight, Alexandre   +3 more
openaire   +2 more sources

Interneuron development and dysfunction [PDF]

open access: yesThe FEBS Journal, 2021
Understanding excitation and inhibition balance in the brain begins with the tale of two basic types of neurons, glutamatergic projection neurons and GABAergic interneurons. The diversity of cortical interneurons is contributed by multiple origins in the ventral forebrain, various tangential migration routes, and complicated regulations of intrinsic ...
Jiaxin Yang, Xiong Yang, Ke Tang
openaire   +2 more sources

Divisive Inhibition Prevails During Simultaneous Optogenetic Activation of All Interneuron Subtypes in Mouse Primary Visual Cortex

open access: yesFrontiers in Neural Circuits, 2019
The mouse primary visual cortex (V1) has become an important brain area for exploring how neural circuits process information. Optogenetic tools have helped to outline the connectivity of a local V1 circuit comprising excitatory pyramidal neurons and ...
Tony G. J. Ingram   +2 more
doaj   +1 more source

The cellular and synaptic architecture of the mechanosensory dorsal horn [PDF]

open access: yes, 2017
The deep dorsal horn is a poorly characterized spinal cord region implicated in processing low-threshold mechanoreceptor (LTMR) information. We report an array of mouse genetic tools for defining neuronal components and functions of the dorsal horn LTMR ...
Abraira   +80 more
core   +1 more source

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