Results 21 to 30 of about 57,859 (281)

Pluripotent stem cell-derived interneuron progenitors mature and restore memory deficits but do not suppress seizures in the epileptic mouse brain

Stem Cell Research, 2018
GABAergic interneuron dysfunction has been implicated in temporal lobe epilepsy (TLE), autism, and schizophrenia. Inhibitory interneuron progenitors transplanted into the hippocampus of rodents with TLE provide varying degrees of seizure suppression.
Nickesha C. Anderson, Meghan A. Van Zandt, Swechhya Shrestha, Daniel B. Lawrence, Jyoti Gupta, Christopher Y. Chen, Felicia A. Harrsch, Trinithas Boyi, Carolyn E. Dundes, Gloster Aaron, Janice R. Naegele, Laura Grabel   +11 more
doaj   +1 more source

Medial Ganglionic Eminence Progenitors Transplanted into Hippocampus Integrate in a Functional and Subtype-Appropriate Manner. [PDF]

, 2017
Medial ganglionic eminence (MGE) transplantation rescues disease phenotypes in various preclinical models with interneuron deficiency or dysfunction, including epilepsy.
Baraban, Scott C, Hsieh, Jui-Yi
core   +1 more source

Microcircuit Rules Governing Impact of Single Interneurons on Purkinje Cell Output In Vivo

Cell Reports, 2020
Summary: The functional impact of single interneurons on neuronal output in vivo and how interneurons are recruited by physiological activity patterns remain poorly understood.
Charlotte Arlt, Michael Häusser
doaj   +1 more source

Modifying PCDH19 levels affects cortical interneuron migration

Frontiers in Neuroscience, 2022
PCDH19 is a transmembrane protein and member of the protocadherin family. It is encoded by the X-chromosome and more than 200 mutations have been linked to the neurodevelopmental PCDH-clustering epilepsy (PCDH19-CE) syndrome.
Anna Pancho, Manuela D. Mitsogiannis, Tania Aerts, Marco Dalla Vecchia, Marco Dalla Vecchia, Marco Dalla Vecchia, Lena K. Ebert, Lena K. Ebert, Lieve Geenen, Lieve Geenen, Lut Noterdaeme, Ria Vanlaer, Anne Stulens, Paco Hulpiau, Paco Hulpiau, Katrien Staes, Frans Van Roy, Peter Dedecker, Bernhard Schermer, Bernhard Schermer, Eve Seuntjens   +20 more
doaj   +1 more source

Genetically altered AMPA-type glutamate receptor kinetics in interneurons disrupt long-range synchrony of gamma oscillation [PDF]

, 2001
Gamma oscillations synchronized between distant neuronal populations may be critical for binding together brain regions devoted to common processing tasks.
A. Bibbig, A. Caputi, Ali, Angulo, Aroniadou, Asada, Bonnerot, Buhl, Catania, Catania, Csicsvari, E. C. Fuchs, Erlander, Ermentrout, Esclapez, Geiger, Geiger, Gu, Guly  s, H. Doheny, H. Faulkner, H. Monyer, He, Hestrin, Jonas, Karbowski, Kondo, Lambolez, Leranth, M. A. Whittington, Mahanty, Martina, Miles, Mosbacher, Mountford, Murakoshi, N. Kopell, Nagy, Petralia, R. D. Traub, Racca, Rozov, Singer, Sommer, Szab  , Traub, Traub, Traub, T  th, Vissavajjhala, Whittington, Whittington   +51 more
core   +3 more sources

Excitatory granule neuron precursors orchestrate laminar localization and differentiation of cerebellar inhibitory interneuron subtypes

Cell Reports, 2021
Summary: GABAergic interneurons migrate long distances through stereotyped migration programs toward specific laminar positions. During their migration, GABAergic interneurons are morphologically alike but then differentiate into a rich array of ...
Christelle Cadilhac, Isabelle Bachy, Antoine Forget, David J. Hodson, Céline Jahannault-Talignani, Andrew J. Furley, Olivier Ayrault, Patrice Mollard, Constantino Sotelo, Fabrice Ango   +9 more
doaj   +1 more source

Central pattern generator for swimming in Melibe [PDF]

, 2005
The nudibranch mollusc Melibe leonina swims by bending from side to side. We have identified a network of neurons that appears to constitute the central pattern generator (CPG) for this locomotor behavior, one of only a few such networks to be described ...
Thompson, Stuart, Watson, Winsor H., III
core   +3 more sources

Local axonal morphology guides the topography of interneuron myelination in mouse and human neocortex

eLife, 2019
GABAergic fast-spiking parvalbumin-positive (PV) interneurons are frequently myelinated in the cerebral cortex. However, the factors governing the topography of cortical interneuron myelination remain incompletely understood.
Jeffrey Stedehouder, Demi Brizee, Johan A Slotman, Maria Pascual-Garcia, Megan L Leyrer, Bibi LJ Bouwen, Clemens MF Dirven, Zhenyu Gao, David M Berson, Adriaan B Houtsmuller, Steven A Kushner   +10 more
doaj   +1 more source

Sonic hedgehog-dependent recruitment of GABAergic interneurons into the developing visual thalamus

eLife, 2022
Axons of retinal ganglion cells (RGCs) play critical roles in the development of inhibitory circuits in visual thalamus. We previously reported that RGC axons signal astrocytes to induce the expression of fibroblast growth factor 15 (FGF15), a motogen ...
Rachana Deven Somaiya, Katelyn Stebbins, Ellen C Gingrich, Hehuang Xie, John N Campbell, A Denise R Garcia, Michael A Fox   +6 more
doaj   +1 more source

Cortical interneurons from human pluripotent stem cells: prospects for neurological and psychiatric disease

Frontiers in Cellular Neuroscience, 2013
Cortical interneurons represent 20% of the cells in the cortex. These cells are local inhibitory neurons whose function is to modulate the firing activities of the excitatory projection neurons.
Charles Edward Arber, Meng eLi, Meng eLi
doaj   +1 more source