Results 21 to 30 of about 57,607 (282)

Pluripotent stem cell-derived interneuron progenitors mature and restore memory deficits but do not suppress seizures in the epileptic mouse brain

open access: yesStem Cell Research, 2018
GABAergic interneuron dysfunction has been implicated in temporal lobe epilepsy (TLE), autism, and schizophrenia. Inhibitory interneuron progenitors transplanted into the hippocampus of rodents with TLE provide varying degrees of seizure suppression.
Nickesha C. Anderson   +11 more
doaj   +1 more source

Microcircuit Rules Governing Impact of Single Interneurons on Purkinje Cell Output In Vivo

open access: yesCell Reports, 2020
Summary: The functional impact of single interneurons on neuronal output in vivo and how interneurons are recruited by physiological activity patterns remain poorly understood.
Charlotte Arlt, Michael Häusser
doaj   +1 more source

The cellular and synaptic architecture of the mechanosensory dorsal horn [PDF]

open access: yes, 2017
The deep dorsal horn is a poorly characterized spinal cord region implicated in processing low-threshold mechanoreceptor (LTMR) information. We report an array of mouse genetic tools for defining neuronal components and functions of the dorsal horn LTMR ...
Abraira   +80 more
core   +1 more source

Medial Ganglionic Eminence Progenitors Transplanted into Hippocampus Integrate in a Functional and Subtype-Appropriate Manner. [PDF]

open access: yes, 2017
Medial ganglionic eminence (MGE) transplantation rescues disease phenotypes in various preclinical models with interneuron deficiency or dysfunction, including epilepsy.
Baraban, Scott C, Hsieh, Jui-Yi
core   +1 more source

Local axonal morphology guides the topography of interneuron myelination in mouse and human neocortex

open access: yeseLife, 2019
GABAergic fast-spiking parvalbumin-positive (PV) interneurons are frequently myelinated in the cerebral cortex. However, the factors governing the topography of cortical interneuron myelination remain incompletely understood.
Jeffrey Stedehouder   +10 more
doaj   +1 more source

Excitatory granule neuron precursors orchestrate laminar localization and differentiation of cerebellar inhibitory interneuron subtypes

open access: yesCell Reports, 2021
Summary: GABAergic interneurons migrate long distances through stereotyped migration programs toward specific laminar positions. During their migration, GABAergic interneurons are morphologically alike but then differentiate into a rich array of ...
Christelle Cadilhac   +9 more
doaj   +1 more source

Central pattern generator for swimming in Melibe [PDF]

open access: yes, 2005
The nudibranch mollusc Melibe leonina swims by bending from side to side. We have identified a network of neurons that appears to constitute the central pattern generator (CPG) for this locomotor behavior, one of only a few such networks to be described ...
Thompson, Stuart, Watson, Winsor H., III
core   +3 more sources

Multiple types of control by identified interneurons in a sensory-activated rhythmic motor pattern. [PDF]

open access: yes, 2001
Modulatory interneurons that can drive central pattern generators (CPGs) are considered as good candidates for decision-making roles in rhythmic behaviors.
Benjamin, Paul R   +2 more
core   +2 more sources

Sonic hedgehog-dependent recruitment of GABAergic interneurons into the developing visual thalamus

open access: yeseLife, 2022
Axons of retinal ganglion cells (RGCs) play critical roles in the development of inhibitory circuits in visual thalamus. We previously reported that RGC axons signal astrocytes to induce the expression of fibroblast growth factor 15 (FGF15), a motogen ...
Rachana Deven Somaiya   +6 more
doaj   +1 more source

Dedicated hippocampal inhibitory networks for locomotion and immobility [PDF]

open access: yes, 2017
Network activity is strongly tied to animal movement; however, hippocampal circuits selectively engaged during locomotion or immobility remain poorly characterized.
Arriaga, Moises, Han, Edward B
core   +2 more sources

Home - About - Disclaimer - Privacy