Results 31 to 40 of about 57,607 (282)

Cortical interneurons from human pluripotent stem cells: prospects for neurological and psychiatric disease

open access: yesFrontiers in Cellular Neuroscience, 2013
Cortical interneurons represent 20% of the cells in the cortex. These cells are local inhibitory neurons whose function is to modulate the firing activities of the excitatory projection neurons.
Charles Edward Arber, Meng eLi, Meng eLi
doaj   +1 more source

Membrane resonance enables stable and robust gamma oscillations [PDF]

open access: yes, 2012
Neuronal mechanisms underlying beta/gamma oscillations (20-80 Hz) are not completely understood. Here, we show that in vivo beta/gamma oscillations in the cat visual cortex sometimes exhibit remarkably stable frequency even when inputs fluctuate ...
Moca, Vasile V.   +3 more
core   +1 more source

Differential Mitochondrial Requirements for Radially and Non-radially Migrating Cortical Neurons: Implications for Mitochondrial Disorders

open access: yesCell Reports, 2016
Mitochondrial dysfunction has been increasingly linked to neurodevelopmental disorders such as intellectual disability, childhood epilepsy, and autism spectrum disorder, conditions also associated with cortical GABAergic interneuron dysfunction. Although
Erika G. Lin-Hendel   +4 more
doaj   +1 more source

Nanoscale-targeted patch-clamp recordings of functional presynaptic ion channels [PDF]

open access: yes, 2013
Important modulatory roles have been attributed to presynaptic NMDA receptors (NMDARs) located on cerebellar interneuron terminals. Evidence supporting a presynaptic location includes an increase in the frequency of mini events following the application ...
Benton, DCH   +4 more
core   +1 more source

Cortical interneurons in autism

open access: yesNature Neuroscience, 2021
The mechanistic underpinnings of autism remain a subject of debate and controversy. Why do individuals with autism share an overlapping set of atypical behaviors and symptoms, despite having different genetic and environmental risk factors? A major challenge in developing new therapies for autism has been the inability to identify convergent neural ...
Anis Contractor   +2 more
openaire   +4 more sources

Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn [PDF]

open access: yes, 2017
The spinal dorsal horn receives input from primary afferent axons, which terminate in a modality-specific fashion in different laminae. The incoming somatosensory information is processed through complex synaptic circuits involving excitatory and ...
Todd, Andrew J.
core   +1 more source

Time lapse recording of cortical interneuron migration in mouse organotypic brain slices and explants

open access: yesSTAR Protocols, 2021
Summary: Interneuron migration involves repetitive cycles of pausing and motion that include nucleokinesis and dynamic branching of the leading process.
Fanny Lepiemme   +2 more
doaj   +1 more source

Interneurons Scratch an Itch [PDF]

open access: yesNeuron, 2014
Itch is immensely frustrating. Most studies focus on the cause of itch. In this issue of Neuron, Kardon et al. (2014) find that itch can be modulated by inhibitory neurons that produce dynorphin, an endogenous agonist of κ-opioid receptors.
Pereira, Paula Juliana Seadi   +1 more
openaire   +2 more sources

Selective expression of KCNS3 potassium channel α-subunit in parvalbumin-containing GABA neurons in the human prefrontal cortex [PDF]

open access: yes, 2012
The cognitive deficits of schizophrenia appear to be associated with altered cortical GABA neurotransmission in the subsets of inhibitory neurons that express either parvalbumin (PV) or somatostatin (SST).
Danko Georgiev   +6 more
core   +7 more sources

Cortical control of chandelier cells in neural codes

open access: yesFrontiers in Cellular Neuroscience, 2022
Various cortical functions arise from the dynamic interplay of excitation and inhibition. GABAergic interneurons that mediate synaptic inhibition display significant diversity in cell morphology, electrophysiology, plasticity rule, and connectivity ...
Kanghoon Jung   +2 more
doaj   +1 more source

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