Results 41 to 50 of about 57,859 (281)

Interneurons Scratch an Itch [PDF]

Neuron, 2014
Itch is immensely frustrating. Most studies focus on the cause of itch. In this issue of Neuron, Kardon et al. (2014) find that itch can be modulated by inhibitory neurons that produce dynorphin, an endogenous agonist of κ-opioid receptors.
Pereira, Paula Juliana Seadi, Lerner, Ethan A.   +1 more
openaire   +2 more sources

The Chromatin Environment Around Interneuron Genes in Oligodendrocyte Precursor Cells and Their Potential for Interneuron Reprograming

Frontiers in Neuroscience, 2019
Oligodendrocyte precursor cells (OPCs), also known as NG2 glia, arise from neural progenitor cells in the embryonic ganglionic eminences that also generate inhibitory neurons.
Linda L. Boshans, Linda L. Boshans, Daniel C. Factor, Vijender Singh, Jia Liu, Chuntao Zhao, Ion Mandoiu, Q. Richard Lu, Patrizia Casaccia, Paul J. Tesar, Akiko Nishiyama, Akiko Nishiyama, Akiko Nishiyama   +12 more
doaj   +1 more source

Transcriptional and imaging-genetic association of cortical interneurons, brain function, and schizophrenia risk

Nature Communications, 2020
Interneuron subtypes have distinct properties and spatial distributions. Here, the authors show that the molecular-genetic basis of cortical resting-state brain function is shaped by distributions of interneuron-related transcripts and may capture ...
Kevin M. Anderson, Meghan A. Collins, Rowena Chin, Tian Ge, Monica D. Rosenberg, Avram J. Holmes   +5 more
doaj   +1 more source

IGF-1 impacts neocortical interneuron connectivity in epileptic spasm generation and resolution

Neurotherapeutics
Little is known about the mechanisms that generate epileptic spasms following perinatal brain injury. Recent studies have implicated reduced levels of Insulin-like Growth Factor 1 (IGF-1) in these patients’ brains.
Carlos J. Ballester-Rosado, John T. Le, Trang T. Lam, Anne E. Anderson, James D. Frost, Jr., John W. Swann   +5 more
doaj   +1 more source

Structured inhibitory activity dynamics in new virtual environments

eLife, 2019
Inhibition plays a powerful role in regulating network excitation and plasticity; however, the activity of defined interneuron types during spatial exploration remain poorly understood.
Moises Arriaga, Edward B Han
doaj   +1 more source

Development in a biologically inspired spinal neural network for movement control [PDF]

, 1997
In two phases, we develop neural network models of spinal circuitry which self-organises into networks with opponent channels for the control of an antagonistic muscle pair.
Bullock, D., Van Heijst, J. J., Vos, J. E.   +2 more
core   +2 more sources

The Interneuron Class Struggle [PDF]

Cell, 2020
In this issue of Cell, Gouwens et al. establish the state of the art for defining inhibitory cell types in the mouse neocortex. By combining morphological, electrophysiological, and transcriptomic features to classify interneurons in the mouse visual cortex, this work provides a roadmap for understanding the diversity of cell types and their functional
Jacob M, Ratliff, Renata, Batista-Brito
openaire   +2 more sources

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Selective expression of KCNS3 potassium channel α-subunit in parvalbumin-containing GABA neurons in the human prefrontal cortex [PDF]

, 2012
The cognitive deficits of schizophrenia appear to be associated with altered cortical GABA neurotransmission in the subsets of inhibitory neurons that express either parvalbumin (PV) or somatostatin (SST).
Danko Georgiev, David A. Lewis, Guillermo González-Burgos, Mitsuru Kikuchi, Takanori Hashimoto, Takeo Yoshikawa, Yoshio Minabe   +6 more
core   +7 more sources

Embryonic temporal-spatial delineation of excitatory spinal V3 interneuron diversity

Cell Reports
Summary: Spinal neural circuits that execute movement are composed of cardinal classes of neurons that emerged from distinct progenitor lineages. Each cardinal class contains multiple neuronal subtypes characterized by distinct molecular, anatomical, and
Dylan Deska-Gauthier, Joanna Borowska-Fielding, Chris Jones, Han Zhang, Colin S. MacKay, Ramez Michail, Laura A. Bennett, Jay B. Bikoff, Ying Zhang   +8 more
doaj   +1 more source