Results 51 to 60 of about 57,607 (282)
Embryonic temporal-spatial delineation of excitatory spinal V3 interneuron diversity
Cell ReportsSummary: Spinal neural circuits that execute movement are composed of cardinal classes of neurons that emerged from distinct progenitor lineages. Each cardinal class contains multiple neuronal subtypes characterized by distinct molecular, anatomical, and
Dylan Deska-Gauthier +8 more
doaj +1 more source
Encoding of Tactile Stimuli by Mechanoreceptors and Interneurons of the Medicinal Leech [PDF]
, 2016 For many animals processing of tactile information is a crucial task in behavioral contexts like exploration, foraging, and stimulus avoidance. The leech, having infrequent access to food, developed an energy efficient reaction to tactile stimuli ...
Fathiazar, Elham +3 more
core +4 more sources
Development of Cortical Interneurons [PDF]
Neuropsychopharmacology, 2014 Inhibitory local circuit neurons (LCNs), often called interneurons, have vital roles in the development and function of cortical networks. Their inhibitory influences regulate both the excitability of cortical projection neurons on the level of individual cells, and the synchronous activity of projection neuron ensembles that appear to be a neural ...
Jianhua, Chu, Stewart A, Anderson
openaire +2 more sources
Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron +5 more
wiley +1 more source
Development in a biologically inspired spinal neural network for movement control [PDF]
, 1997 In two phases, we develop neural network models of spinal circuitry which self-organises into networks with opponent channels for the control of an antagonistic muscle pair.
Bullock, D. +2 more
core +2 more sources
Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
Thalamo-cortical axons regulate the radial dispersion of neocortical GABAergic interneurons
eLife, 2016 Neocortical GABAergic interneuron migration and thalamo-cortical axon (TCA) pathfinding follow similar trajectories and timing, suggesting they may be interdependent.
Sabrina Zechel +2 more
doaj +1 more source
Hilar GABAergic interneuron activity controls spatial learning and memory retrieval. [PDF]
PLoS ONE, 2012 Although extensive research has demonstrated the importance of excitatory granule neurons in the dentate gyrus of the hippocampus in normal learning and memory and in the pathogenesis of amnesia in Alzheimer's disease (AD), the role of hilar GABAergic ...
Yaisa Andrews-Zwilling +13 more
doaj +1 more source
Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease. [PDF]
, 2019 Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD), increasing risk and decreasing age of disease onset. Many studies have demonstrated the detrimental effects of apoE4 in varying cellular contexts.
Huang, Yadong +2 more
core +1 more source
Advanced Functional Materials, EarlyView.We present ultrathin flexible transparent electrodes through iCVD‐enabled molecular control of 10 nm gold films on poly(dimethylaminomethylstyrene). In vivo validation demonstrated photoelectric artifact reduction vs. opaque electrodes and preservation of natural neural dynamics.
Tae Jin Mun +11 more
wiley +1 more source