Results 171 to 180 of about 145,959 (288)

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Distinct Activity Profiles of Somatostatin-Expressing Interneurons in the Neocortex

Frontiers in Cellular Neuroscience, 2017
Srikanth Ramaswamy, Cristina Colangelo, Eilif B. Muller   +2 more
doaj   +1 more source

Selective Lis1 inactivation disrupts migration and positioning of cortical somatostatin interneurons. [PDF]

Sci Rep
Pombero A, García-López R, Geijo-Barrientos E, Martínez S.   +3 more
europepmc   +1 more source

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Subthreshold Kir and I_h currents modulate excitability of layer 1 VIP interneurons in the medial prefrontal cortex. [PDF]

Biol Res
Moreno C, Riquelme D, Cornejo C, Leyton P, Leiva-Salcedo E.   +4 more
europepmc   +1 more source

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

The Contribution of Dysfunctional Chloride Channels to Neurovascular Deficiency and Neurodegeneration

Frontiers in Pharmacology, 2021
David A. Gascoigne, Alexander Drobyshevsky, Daniil P. Aksenov, Daniil P. Aksenov   +3 more
doaj   +1 more source

Oxytocin facilitates social behavior of female rats via selective modulation of interneurons in the medial prefrontal cortex. [PDF]

Nat Commun
Schimmer S, Kania A, Lefevre A, Afordakos K, Wang KY, Lebedeva J, Rozov A, Raftogianni A, Tiwari R, Netser S, Zovko A, Shaheen H, Schimmer J, Patwell R, Denis C, Grelot V, Petitjean H, Geng L, Hefter D, Boender A, Podpecan Y, Schommer F, Schubert T, Sanetra A, Trenk A, Gugula A, Hurlemann R, Wagner S, Li Y, Althammer F, Blasiak A, Melzer S, Monyer H, Charlet A, Eliava M, Grinevich V.   +35 more
europepmc   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

Social familiarity strengthens neural and vocal responses to conspecific calls in zebra finches. [PDF]

PLoS Comput Biol
Gomez-Guzman CM, Vallentin D, Benichov JI.   +2 more
europepmc   +1 more source